HeartShare is an NHLBI-funded program to conduct large-scale analysis of phenotypic data, images, and omics from multiple existing datasets and from a new, prospective, multi-center cohort of patients with heart failure with preserved ejection fraction (HFpEF) and comparators. The goal of this study is to classify HFpEF into distinct phenotypes, characterize mechanisms of disease, and identify therapeutic targets for each HFpEF subtype. In 2017, NHLBI convened a working group to establish research priorities in HFpEF due to its growing prevalence and lack of effective treatments. One of the key opportunities identified by the working group was to create a comprehensive, multi-center, deeply phenotyped cohort of HFpEF patients with standardized protocols and a robust biorepository. In 2020, NHLBI created funding opportunities for a Data Translation Center (RFA-HL-21-016) and 6 clinical centers (RFA-HL-21-015).

Organization of HeartShare

The HeartShare Data Translation Center at Northwestern University serves as the hub for coordinating the study and integrating all HeartShare data (existing datasets and prospective data). The 6 HeartShare Clinical Centers (Massachusetts General Hospital/Brigham and Women’s Hospital, Mayo Clinic, Northwestern University, University of Pennsylvania, University of California-Davis, and Wake Forest University, are conducting the prospective deep phenotyping part of the study (n=1000 participants) under the direction of the HeartShare Data Translation Center.