HeartShare - Harmonized Academic Trial Data

HeartShare - Harmonized Academic Trial Data

Summary of variables at baseline

Last updated: 2024-09-18

This report is was prepared using data from: hdcp phenotype data text2.csv.

---

Baseline Summary Tables

---

On ACE/ARB

Variable used: acearb

Additional label: ACEI/ARB

Study	No	Yes	Total
ATHENA	149 (41.4%)	211 (58.6%)	360 (100.0%)
CARRESS	87 (46.3%)	101 (53.7%)	188 (100.0%)
DOSE	111 (36.0%)	197 (64.0%)	308 (100.0%)
ESCAPE	369 (85.2%)	64 (14.8%)	433 (100.0%)
EXACT	39 (15.4%)	214 (84.6%)	253 (100.0%)
FIGHT	84 (28.0%)	216 (72.0%)	300 (100.0%)
GUIDE-IT	186 (20.8%)	708 (79.2%)	894 (100.0%)
HF-ACTION	119 (5.6%)	2,011 (94.4%)	2,130 (100.0%)
INDIE-HFpEF	49 (46.7%)	56 (53.3%)	105 (100.0%)
NEAT-HFpEF	40 (36.4%)	70 (63.6%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	216 (100.0%)
ROSE	181 (50.3%)	179 (49.7%)	360 (100.0%)
SCD-HeFT	89 (3.5%)	2,432 (96.5%)	2,521 (100.0%)
SOLVD Prevent	2,118 (50.1%)	2,110 (49.9%)	4,228 (100.0%)
SOLVD Registry	4,374 (69.7%)	1,899 (30.3%)	6,273 (100.0%)
SOLVD Treat	1,284 (50.0%)	1,285 (50.0%)	2,569 (100.0%)
STICH	309 (11.8%)	2,311 (88.2%)	2,620 (100.0%)
TOPCAT	545 (15.8%)	2,900 (84.2%)	3,445 (100.0%)
Total	10,349 (37.9%)	16,964 (62.1%)	27,313 (100.0%)

On ACE-inhibitor

Variable used: acei

Additional label: ACEI

Study	No	Yes	Total
ATHENA	206 (57.2%)	154 (42.8%)	360 (100.0%)
CARRESS	121 (64.4%)	67 (35.6%)	188 (100.0%)
DOSE	171 (55.5%)	137 (44.5%)	308 (100.0%)
ESCAPE	433 (100.0%)	0 (0.0%)	433 (100.0%)
EXACT	88 (34.8%)	165 (65.2%)	253 (100.0%)
FIGHT	143 (47.7%)	157 (52.3%)	300 (100.0%)
GUIDE-IT	329 (36.8%)	565 (63.2%)	894 (100.0%)
HF-ACTION	539 (25.3%)	1,591 (74.7%)	2,130 (100.0%)
INDIE-HFpEF	78 (74.3%)	27 (25.7%)	105 (100.0%)
NEAT-HFpEF	73 (66.4%)	37 (33.6%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	216 (100.0%)
ROSE	234 (65.0%)	126 (35.0%)	360 (100.0%)
SCD-HeFT	388 (15.4%)	2,133 (84.6%)	2,521 (100.0%)
SOLVD Prevent	2,118 (50.1%)	2,110 (49.9%)	4,228 (100.0%)
SOLVD Registry	4,374 (69.7%)	1,899 (30.3%)	6,273 (100.0%)
SOLVD Treat	1,284 (50.0%)	1,285 (50.0%)	2,569 (100.0%)
STICH	503 (19.2%)	2,117 (80.8%)	2,620 (100.0%)
TOPCAT	1,193 (34.6%)	2,252 (65.4%)	3,445 (100.0%)
Total	12,491 (45.7%)	14,822 (54.3%)	27,313 (100.0%)

Atrial fibrillation/flutter

Variable used: af

Additional label: AF/FLU

Study	No	Yes	Total
ATHENA	188 (52.2%)	172 (47.8%)	360 (100.0%)
CARRESS	86 (45.7%)	102 (54.3%)	188 (100.0%)
DOSE	146 (47.4%)	162 (52.6%)	308 (100.0%)
ESCAPE	306 (70.7%)	127 (29.3%)	433 (100.0%)
EXACT	129 (51.0%)	124 (49.0%)	253 (100.0%)
FIGHT	146 (48.7%)	154 (51.3%)	300 (100.0%)
GUIDE-IT	536 (60.0%)	358 (40.0%)	894 (100.0%)
HF-ACTION	1,687 (79.2%)	443 (20.8%)	2,130 (100.0%)
INDIE-HFpEF	105 (100.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	70 (63.6%)	40 (36.4%)	110 (100.0%)
RELAX	105 (48.6%)	111 (51.4%)	216 (100.0%)
ROSE	145 (40.3%)	215 (59.7%)	360 (100.0%)
SCD-HeFT	2,131 (84.5%)	390 (15.5%)	2,521 (100.0%)
SOLVD Prevent	3,714 (87.8%)	514 (12.2%)	4,228 (100.0%)
SOLVD Registry	5,514 (87.9%)	759 (12.1%)	6,273 (100.0%)
SOLVD Treat	2,285 (88.9%)	284 (11.1%)	2,569 (100.0%)
STICH	2,278 (86.9%)	342 (13.1%)	2,620 (100.0%)
TOPCAT	2,231 (64.8%)	1,214 (35.2%)	3,445 (100.0%)
Total	21,802 (79.8%)	5,511 (20.2%)	27,313 (100.0%)

Atrial fibrillation on admit

Variable used: af_admit

Additional label: AF on admit

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	128 (68.1%)	60 (31.9%)	0 (0.0%)	188 (100.0%)
DOSE	207 (67.2%)	101 (32.8%)	0 (0.0%)	308 (100.0%)
ESCAPE	375 (86.6%)	58 (13.4%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	227 (63.1%)	133 (36.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	937 (3.4%)	352 (1.3%)	26,024 (95.3%)	27,313 (100.0%)

Atrial fibrillation type

Variable used: af_type

Additional label: NA

Study	Chronic	New onset	Paroxysmal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	58 (30.9%)	5 (2.7%)	39 (20.7%)	86 (45.7%)	188 (100.0%)
DOSE	103 (33.4%)	6 (1.9%)	53 (17.2%)	146 (47.4%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	65 (25.7%)	8 (3.2%)	51 (20.2%)	129 (51.0%)	253 (100.0%)
FIGHT	76 (25.3%)	5 (1.7%)	47 (15.7%)	172 (57.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	20 (18.2%)	1 (0.9%)	14 (12.7%)	75 (68.2%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	138 (38.3%)	7 (1.9%)	70 (19.4%)	145 (40.3%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	460 (1.7%)	32 (0.1%)	274 (1.0%)	26,547 (97.2%)	27,313 (100.0%)

Age category

Variable used: age_cat

Additional label: Age, yrs

Study	< 55	55-75	75+	Unknown	Total
ATHENA	83 (23.1%)	188 (52.2%)	89 (24.7%)	0 (0.0%)	360 (100.0%)
CARRESS	29 (15.4%)	98 (52.1%)	61 (32.4%)	0 (0.0%)	188 (100.0%)
DOSE	68 (22.1%)	146 (47.4%)	94 (30.5%)	0 (0.0%)	308 (100.0%)
ESCAPE	193 (44.6%)	197 (45.5%)	43 (9.9%)	0 (0.0%)	433 (100.0%)
EXACT	71 (28.1%)	137 (54.2%)	45 (17.8%)	0 (0.0%)	253 (100.0%)
FIGHT	94 (31.3%)	177 (59.0%)	29 (9.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	261 (29.2%)	487 (54.5%)	146 (16.3%)	0 (0.0%)	894 (100.0%)
HF-ACTION	757 (35.5%)	1,186 (55.7%)	187 (8.8%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	7 (6.7%)	73 (69.5%)	25 (23.8%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	5 (4.5%)	79 (71.8%)	26 (23.6%)	0 (0.0%)	110 (100.0%)
RELAX	23 (10.6%)	127 (58.8%)	66 (30.6%)	0 (0.0%)	216 (100.0%)
ROSE	45 (12.5%)	192 (53.3%)	123 (34.2%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	872 (34.6%)	1,452 (57.6%)	197 (7.8%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	1,317 (31.1%)	2,778 (65.7%)	133 (3.1%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	1,521 (24.2%)	4,001 (63.8%)	748 (11.9%)	3 (0.0%)	6,273 (100.0%)
SOLVD Treat	641 (25.0%)	1,811 (70.5%)	117 (4.6%)	0 (0.0%)	2,569 (100.0%)
STICH	703 (26.8%)	1,668 (63.7%)	237 (9.0%)	12 (0.5%)	2,620 (100.0%)
TOPCAT	268 (7.8%)	2,273 (66.0%)	904 (26.2%)	0 (0.0%)	3,445 (100.0%)
Total	6,958 (25.5%)	17,070 (62.5%)	3,270 (12.0%)	15 (0.1%)	27,313 (100.0%)

Age value

Variable used: age_val

Additional label: Age, yrs

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	22.0	55.00	65.00	75.00	90.00	64.66	14.04
CARRESS	188	0	34.0	59.75	68.00	78.00	90.00	67.93	12.79
DOSE	308	0	28.0	56.00	68.00	77.00	88.00	66.04	13.60
ESCAPE	433	0	20.0	47.00	56.00	66.00	88.00	56.13	13.92
EXACT	253	0	20.0	53.00	63.00	72.00	89.00	61.95	13.61
FIGHT	300	0	26.0	51.75	61.00	68.00	89.00	59.72	12.53
GUIDE-IT	894	0	21.0	53.00	63.00	71.00	90.00	61.48	13.87
HF-ACTION	2130	0	19.0	51.00	59.00	68.00	90.00	58.56	12.68
INDIE-HFpEF	105	0	40.0	61.00	68.00	75.00	87.00	67.69	10.09
NEAT-HFpEF	110	0	50.0	62.25	69.00	75.00	90.00	69.28	9.23
RELAX	216	0	32.0	62.00	69.00	77.00	90.00	68.53	10.25
ROSE	360	0	25.0	62.00	70.00	79.00	90.00	69.52	12.20
SCD-HeFT	2521	0	19.0	51.00	60.00	68.00	90.00	59.03	11.91
SOLVD Prevent	4228	0	27.0	52.00	60.00	66.00	80.00	58.67	10.34
SOLVD Registry	6273	3	21.0	55.00	63.00	70.00	95.00	61.98	12.04
SOLVD Treat	2569	0	27.0	55.00	61.00	67.00	80.00	60.39	9.88
STICH	2620	12	30.1	54.39	61.33	68.82	89.73	61.58	9.82
TOPCAT	3445	0	50.0	61.00	69.00	76.00	90.00	68.56	9.59
Overall	27313	15	19.0	54.00	62.00	70.00	95.00	61.76	11.80

Heart failure assessment

Variable used: ahf_type

Additional label: NA

Study	Dry/cold	Dry/warm	Wet/cold	Wet/warm	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	14 (3.2%)	54 (12.5%)	97 (22.4%)	265 (61.2%)	3 (0.7%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	14 (0.1%)	54 (0.2%)	97 (0.4%)	265 (1.0%)	26,883 (98.4%)	27,313 (100.0%)

Albumin value

Variable used: albumin

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	60	1.70	3.1	3.4	3.73	5.0	3.39	0.54
DOSE	308	109	1.50	3.1	3.4	3.80	5.0	3.43	0.56
ESCAPE	433	109	1.70	3.3	3.6	4.00	8.2	3.63	0.58
EXACT	253	14	2.90	3.7	4.0	4.30	5.1	3.99	0.43
FIGHT	300	32	0.21	3.3	3.7	4.00	5.4	3.65	0.59
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	96	1.50	3.7	4.1	4.40	4.8	3.98	0.52
ROSE	360	99	2.10	3.2	3.6	3.90	5.0	3.56	0.50
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25774	0.21	3.3	3.7	4.10	8.2	3.66	0.57

Absolute lymphocyte count

Variable used: alc

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	67	0.22	0.76	1.08	1.46	3.13	1.20	0.62
DOSE	308	91	0.17	1.45	2.22	3.40	7.05	2.58	1.52
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	86	0.44	1.09	1.48	1.94	22.92	1.77	2.09
ROSE	360	107	0.20	0.78	1.06	1.50	5.98	1.22	0.70
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	192	0.15	1.56	2.00	2.52	9.60	2.11	0.83
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	139	0.25	1.40	1.89	2.45	9.60	2.02	0.87
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	20126	0.15	1.44	1.92	2.48	22.92	2.04	0.93

Aldosterone value

Variable used: aldo_val

Additional label: Aldosterone

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	5.00	126.88	237.70	427.78	2600.00	422.41	539.22
DOSE	308	32	1.35	103.54	198.90	354.57	2149.16	292.49	318.61
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	2	18.87	118.65	188.85	282.16	2600.00	250.87	250.24
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26641	1.35	114.50	202.31	349.16	2600.00	314.42	380.21

On allopurinol

Variable used: allopurinol

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	386 (89.1%)	47 (10.9%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	792 (88.6%)	102 (11.4%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,178 (4.3%)	149 (0.5%)	25,986 (95.1%)	27,313 (100.0%)

ALT

Variable used: alt

Additional label: ALT

Study	< 50	50-75	75+	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	105 (55.9%)	6 (3.2%)	9 (4.8%)	68 (36.2%)	188 (100.0%)
DOSE	158 (51.3%)	16 (5.2%)	17 (5.5%)	117 (38.0%)	308 (100.0%)
ESCAPE	278 (64.2%)	29 (6.7%)	29 (6.7%)	97 (22.4%)	433 (100.0%)
EXACT	226 (89.3%)	15 (5.9%)	5 (2.0%)	7 (2.8%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	96 (91.4%)	5 (4.8%)	2 (1.9%)	2 (1.9%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	110 (50.9%)	7 (3.2%)	6 (2.8%)	93 (43.1%)	216 (100.0%)
ROSE	237 (65.8%)	11 (3.1%)	14 (3.9%)	98 (27.2%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	3,227 (93.7%)	132 (3.8%)	44 (1.3%)	42 (1.2%)	3,445 (100.0%)
Total	4,437 (16.2%)	221 (0.8%)	126 (0.5%)	22,529 (82.5%)	27,313 (100.0%)

Anemia

Variable used: anemia

Additional label: Anemia

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	32 (17.0%)	155 (82.4%)	1 (0.5%)	188 (100.0%)
DOSE	93 (30.2%)	209 (67.9%)	6 (1.9%)	308 (100.0%)
ESCAPE	151 (34.9%)	270 (62.4%)	12 (2.8%)	433 (100.0%)
EXACT	101 (39.9%)	148 (58.5%)	4 (1.6%)	253 (100.0%)
FIGHT	129 (43.0%)	164 (54.7%)	7 (2.3%)	300 (100.0%)
GUIDE-IT	123 (13.8%)	101 (11.3%)	670 (74.9%)	894 (100.0%)
HF-ACTION	836 (39.2%)	772 (36.2%)	522 (24.5%)	2,130 (100.0%)
INDIE-HFpEF	74 (70.5%)	29 (27.6%)	2 (1.9%)	105 (100.0%)
NEAT-HFpEF	71 (64.5%)	38 (34.5%)	1 (0.9%)	110 (100.0%)
RELAX	100 (46.3%)	115 (53.2%)	1 (0.5%)	216 (100.0%)
ROSE	81 (22.5%)	274 (76.1%)	5 (1.4%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	3,247 (76.8%)	897 (21.2%)	84 (2.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	1,855 (72.2%)	651 (25.3%)	63 (2.5%)	2,569 (100.0%)
STICH	1,239 (47.3%)	1,335 (51.0%)	46 (1.8%)	2,620 (100.0%)
TOPCAT	2,268 (65.8%)	1,150 (33.4%)	27 (0.8%)	3,445 (100.0%)
Total	10,400 (38.1%)	6,308 (23.1%)	10,605 (38.8%)	27,313 (100.0%)

Angina

Variable used: angina

Additional label: Angina

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	153 (81.4%)	35 (18.6%)	0 (0.0%)	188 (100.0%)
DOSE	271 (88.0%)	37 (12.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	291 (67.2%)	142 (32.8%)	0 (0.0%)	433 (100.0%)
EXACT	214 (84.6%)	39 (15.4%)	0 (0.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	1,603 (75.3%)	527 (24.7%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	184 (85.2%)	32 (14.8%)	0 (0.0%)	216 (100.0%)
ROSE	298 (82.8%)	62 (17.2%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,857 (73.7%)	664 (26.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	1,821 (43.1%)	2,407 (56.9%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	2,662 (42.4%)	3,611 (57.6%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	1,085 (42.2%)	1,484 (57.8%)	0 (0.0%)	2,569 (100.0%)
STICH	902 (34.4%)	1,718 (65.6%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	1,832 (53.2%)	1,613 (46.8%)	0 (0.0%)	3,445 (100.0%)
Total	13,173 (48.2%)	12,371 (45.3%)	1,769 (6.5%)	27,313 (100.0%)

On antiarrhythmic

Variable used: antiarrhyth

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	360 (100.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	160 (85.1%)	28 (14.9%)	0 (0.0%)	188 (100.0%)
DOSE	261 (84.7%)	47 (15.3%)	0 (0.0%)	308 (100.0%)
ESCAPE	339 (78.3%)	94 (21.7%)	0 (0.0%)	433 (100.0%)
EXACT	194 (76.7%)	59 (23.3%)	0 (0.0%)	253 (100.0%)
FIGHT	218 (72.7%)	82 (27.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	750 (83.9%)	144 (16.1%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	104 (94.5%)	6 (5.5%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	279 (77.5%)	81 (22.5%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,674 (66.4%)	847 (33.6%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	3,591 (84.9%)	637 (15.1%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	4,921 (78.4%)	1,352 (21.6%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	2,007 (78.1%)	562 (21.9%)	0 (0.0%)	2,569 (100.0%)
STICH	2,291 (87.4%)	329 (12.6%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,150 (91.4%)	295 (8.6%)	0 (0.0%)	3,445 (100.0%)
Total	22,645 (82.9%)	4,563 (16.7%)	105 (0.4%)	27,313 (100.0%)

Aortic regurgitation

Variable used: aortic_regurg

Additional label: AR

Study	Moderate/severe	No	Normal/Mild	Unknown	Total
ATHENA	20 (5.6%)	340 (94.4%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	12 (6.4%)	46 (24.5%)	130 (69.1%)	0 (0.0%)	188 (100.0%)
DOSE	15 (4.9%)	56 (18.2%)	237 (76.9%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	433 (100.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)
EXACT	6 (2.4%)	41 (16.2%)	206 (81.4%)	0 (0.0%)	253 (100.0%)
FIGHT	5 (1.7%)	295 (98.3%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	105 (100.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	110 (100.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	7 (3.2%)	1 (0.5%)	208 (96.3%)	0 (0.0%)	216 (100.0%)
ROSE	21 (5.8%)	43 (11.9%)	296 (82.2%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	57 (2.3%)	2,464 (97.7%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	143 (0.5%)	3,934 (14.4%)	1,077 (3.9%)	22,159 (81.1%)	27,313 (100.0%)

Aortic stenosis

Variable used: aortic_stenosis

Additional label: AS

Study	Moderate/severe	No	Normal/Mild	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	18 (9.6%)	44 (23.4%)	126 (67.0%)	0 (0.0%)	188 (100.0%)
DOSE	12 (3.9%)	53 (17.2%)	243 (78.9%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	433 (100.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)
EXACT	5 (2.0%)	42 (16.6%)	206 (81.4%)	0 (0.0%)	253 (100.0%)
FIGHT	4 (1.3%)	296 (98.7%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	1 (0.9%)	109 (99.1%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	0 (0.0%)	2 (0.9%)	214 (99.1%)	0 (0.0%)	216 (100.0%)
ROSE	12 (3.3%)	46 (12.8%)	302 (83.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	39 (1.5%)	2,482 (98.5%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	91 (0.3%)	3,507 (12.8%)	1,091 (4.0%)	22,624 (82.8%)	27,313 (100.0%)

Aortic stenosis - echo

Variable used: aortic_stenosis_echo

Additional label: NA

Study	Moderate/severe	Normal/Mild	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	4 (0.1%)	422 (12.2%)	3,019 (87.6%)	3,445 (100.0%)
Total	4 (0.0%)	422 (1.5%)	26,887 (98.4%)	27,313 (100.0%)

On ARB

Variable used: arb

Additional label: ARB

Study	No	Yes	Unknown	Total
ATHENA	301 (83.6%)	59 (16.4%)	0 (0.0%)	360 (100.0%)
CARRESS	147 (78.2%)	41 (21.8%)	0 (0.0%)	188 (100.0%)
DOSE	242 (78.6%)	66 (21.4%)	0 (0.0%)	308 (100.0%)
ESCAPE	369 (85.2%)	64 (14.8%)	0 (0.0%)	433 (100.0%)
EXACT	201 (79.4%)	52 (20.6%)	0 (0.0%)	253 (100.0%)
FIGHT	241 (80.3%)	59 (19.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	745 (83.3%)	149 (16.7%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,637 (76.9%)	493 (23.1%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	76 (72.4%)	29 (27.6%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	76 (69.1%)	34 (30.9%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	2,157 (85.6%)	364 (14.4%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	4,228 (100.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	6,273 (100.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	2,569 (100.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)
STICH	2,368 (90.4%)	252 (9.6%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	2,747 (79.7%)	698 (20.3%)	0 (0.0%)	3,445 (100.0%)
Total	24,593 (90.0%)	2,360 (8.6%)	360 (1.3%)	27,313 (100.0%)

On aspirin

Variable used: asa

Additional label: NA

Study	No	Yes	Total
ATHENA	161 (44.7%)	199 (55.3%)	360 (100.0%)
CARRESS	57 (30.3%)	131 (69.7%)	188 (100.0%)
DOSE	98 (31.8%)	210 (68.2%)	308 (100.0%)
ESCAPE	207 (47.8%)	226 (52.2%)	433 (100.0%)
EXACT	78 (30.8%)	175 (69.2%)	253 (100.0%)
FIGHT	96 (32.0%)	204 (68.0%)	300 (100.0%)
GUIDE-IT	373 (41.7%)	521 (58.3%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	52 (49.5%)	53 (50.5%)	105 (100.0%)
NEAT-HFpEF	46 (41.8%)	64 (58.2%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	216 (100.0%)
ROSE	129 (35.8%)	231 (64.2%)	360 (100.0%)
SCD-HeFT	1,106 (43.9%)	1,415 (56.1%)	2,521 (100.0%)
SOLVD Prevent	1,936 (45.8%)	2,292 (54.2%)	4,228 (100.0%)
SOLVD Registry	3,936 (62.7%)	2,337 (37.3%)	6,273 (100.0%)
SOLVD Treat	1,708 (66.5%)	861 (33.5%)	2,569 (100.0%)
STICH	560 (21.4%)	2,060 (78.6%)	2,620 (100.0%)
TOPCAT	1,195 (34.7%)	2,250 (65.3%)	3,445 (100.0%)
Total	14,084 (51.6%)	13,229 (48.4%)	27,313 (100.0%)

AST value

Variable used: ast

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	64	10.0	20.0	28	39.75	182	38.63	31.82
DOSE	308	102	10.0	22.0	28	43.00	537	42.58	49.22
ESCAPE	433	92	10.0	22.0	29	39.00	995	39.44	58.82
EXACT	253	8	12.0	20.0	25	32.00	102	27.40	11.58
FIGHT	300	25	6.0	20.5	27	35.00	224	31.70	22.90
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	2	10.0	18.0	22	29.50	128	25.98	14.31
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	9	2.8	21.0	26	33.00	106	29.03	14.00
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25812	2.8	21.0	27	36.00	995	34.06	37.30

On evidence-based beta-blocker

Variable used: bb_evidence

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	181 (41.8%)	252 (58.2%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	110 (12.3%)	784 (87.7%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	980 (38.9%)	1,541 (61.1%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	3,401 (12.5%)	2,577 (9.4%)	21,335 (78.1%)	27,313 (100.0%)

On other beta-blocker

Variable used: bb_other

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	416 (96.1%)	17 (3.9%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	833 (93.2%)	61 (6.8%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	2,323 (92.1%)	198 (7.9%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	5,702 (20.9%)	276 (1.0%)	21,335 (78.1%)	27,313 (100.0%)

Any BBB

Variable used: bbb

Additional label: BBB

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	316 (73.0%)	117 (27.0%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	1,715 (80.5%)	415 (19.5%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,845 (82.6%)	600 (17.4%)	0 (0.0%)	3,445 (100.0%)
Total	4,876 (17.9%)	1,132 (4.1%)	21,305 (78.0%)	27,313 (100.0%)

Beck Depression Inventory Score

Variable used: bdi

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	145	0	5	9	16	63	11.57	9.28
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25328	0	5	9	16	63	11.57	9.28

On beta-blocker

Variable used: betab

Additional label: BB

Study	No	Yes	Total
ATHENA	78 (21.7%)	282 (78.3%)	360 (100.0%)
CARRESS	41 (21.8%)	147 (78.2%)	188 (100.0%)
DOSE	52 (16.9%)	256 (83.1%)	308 (100.0%)
ESCAPE	164 (37.9%)	269 (62.1%)	433 (100.0%)
EXACT	12 (4.7%)	241 (95.3%)	253 (100.0%)
FIGHT	18 (6.0%)	282 (94.0%)	300 (100.0%)
GUIDE-IT	49 (5.5%)	845 (94.5%)	894 (100.0%)
HF-ACTION	118 (5.5%)	2,012 (94.5%)	2,130 (100.0%)
INDIE-HFpEF	38 (36.2%)	67 (63.8%)	105 (100.0%)
NEAT-HFpEF	33 (30.0%)	77 (70.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	216 (100.0%)
ROSE	60 (16.7%)	300 (83.3%)	360 (100.0%)
SCD-HeFT	783 (31.1%)	1,738 (68.9%)	2,521 (100.0%)
SOLVD Prevent	3,213 (76.0%)	1,015 (24.0%)	4,228 (100.0%)
SOLVD Registry	5,300 (84.5%)	973 (15.5%)	6,273 (100.0%)
SOLVD Treat	2,372 (92.3%)	197 (7.7%)	2,569 (100.0%)
STICH	392 (15.0%)	2,228 (85.0%)	2,620 (100.0%)
TOPCAT	2,679 (77.8%)	766 (22.2%)	3,445 (100.0%)
Total	15,618 (57.2%)	11,695 (42.8%)	27,313 (100.0%)

BMI

Variable used: bmi

Additional label: BMI

Study	Normal	Obese	Overweight	Underweight	Unknown	Total
ATHENA	65 (18.1%)	192 (53.3%)	97 (26.9%)	2 (0.6%)	4 (1.1%)	360 (100.0%)
CARRESS	21 (11.2%)	112 (59.6%)	47 (25.0%)	1 (0.5%)	7 (3.7%)	188 (100.0%)
DOSE	43 (14.0%)	174 (56.5%)	75 (24.4%)	0 (0.0%)	16 (5.2%)	308 (100.0%)
ESCAPE	118 (27.3%)	151 (34.9%)	143 (33.0%)	8 (1.8%)	13 (3.0%)	433 (100.0%)
EXACT	40 (15.8%)	138 (54.5%)	71 (28.1%)	1 (0.4%)	3 (1.2%)	253 (100.0%)
FIGHT	60 (20.0%)	165 (55.0%)	71 (23.7%)	2 (0.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	223 (24.9%)	372 (41.6%)	267 (29.9%)	11 (1.2%)	21 (2.3%)	894 (100.0%)
HF-ACTION	415 (19.5%)	1,036 (48.6%)	664 (31.2%)	10 (0.5%)	5 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	5 (4.8%)	77 (73.3%)	23 (21.9%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	9 (8.2%)	82 (74.5%)	19 (17.3%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	15 (6.9%)	148 (68.5%)	53 (24.5%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	62 (17.2%)	196 (54.4%)	94 (26.1%)	1 (0.3%)	7 (1.9%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	1,629 (26.0%)	1,051 (16.8%)	1,820 (29.0%)	122 (1.9%)	1,651 (26.3%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	801 (30.6%)	678 (25.9%)	1,081 (41.3%)	26 (1.0%)	34 (1.3%)	2,620 (100.0%)
TOPCAT	427 (12.4%)	1,902 (55.2%)	1,091 (31.7%)	15 (0.4%)	10 (0.3%)	3,445 (100.0%)
Total	3,933 (14.4%)	6,474 (23.7%)	5,616 (20.6%)	199 (0.7%)	11,091 (40.6%)	27,313 (100.0%)

BMI value

Variable used: bmi_val

Additional label: BMI, kg/m2

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	4	17.56	26.16	30.99	37.21	74.04	33.01	9.75
CARRESS	188	7	18.10	27.40	33.10	41.10	95.70	35.33	10.65
DOSE	308	16	18.50	26.67	31.50	36.52	68.50	33.11	8.84
ESCAPE	433	13	15.60	24.10	27.85	32.82	55.80	28.94	6.63
EXACT	253	3	18.30	26.22	31.15	37.32	66.90	32.39	8.09
FIGHT	300	2	15.70	26.00	31.65	36.48	51.20	31.56	6.97
GUIDE-IT	894	21	11.95	24.68	28.83	33.92	75.67	30.30	8.14
HF-ACTION	2130	5	12.61	25.88	29.84	35.08	71.90	30.99	7.13
INDIE-HFpEF	105	0	18.54	29.89	35.66	38.74	48.66	34.78	6.38
NEAT-HFpEF	110	0	19.93	29.83	34.81	41.68	64.11	35.72	8.38
RELAX	216	0	20.50	28.40	33.30	38.82	54.30	34.15	7.01
ROSE	360	7	17.80	26.50	31.00	37.00	62.70	32.35	8.02
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	1651	10.44	23.57	26.35	29.65	80.61	27.05	5.63
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	34	15.00	24.22	26.99	30.15	50.00	27.56	4.84
TOPCAT	3445	10	16.53	27.13	30.86	35.71	70.41	32.07	7.10
Overall	27313	11091	10.44	24.92	28.41	33.20	95.70	29.75	7.08

BNP

Variable used: bnp

Additional label: BNP

Study	Abnormal	Normal	Unknown	Total
ATHENA	98 (27.2%)	58 (16.1%)	204 (56.7%)	360 (100.0%)
CARRESS	52 (27.7%)	41 (21.8%)	95 (50.5%)	188 (100.0%)
DOSE	120 (39.0%)	70 (22.7%)	118 (38.3%)	308 (100.0%)
ESCAPE	137 (31.6%)	222 (51.3%)	74 (17.1%)	433 (100.0%)
EXACT	22 (8.7%)	60 (23.7%)	171 (67.6%)	253 (100.0%)
FIGHT	16 (5.3%)	11 (3.7%)	273 (91.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	115 (5.4%)	647 (30.4%)	1,368 (64.2%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	5 (2.3%)	0 (0.0%)	211 (97.7%)	216 (100.0%)
ROSE	58 (16.1%)	38 (10.6%)	264 (73.3%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	187 (7.1%)	1,096 (41.8%)	1,337 (51.0%)	2,620 (100.0%)
TOPCAT	71 (2.1%)	731 (21.2%)	2,643 (76.7%)	3,445 (100.0%)
Total	881 (3.2%)	2,974 (10.9%)	23,458 (85.9%)	27,313 (100.0%)

BNP value

Variable used: bnp_val

Additional label: BNP, pg/ml

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	204	255.7	589.75	1083.00	1721.00	9533.0	1342.40	1132.37
CARRESS	188	95	38.0	348.00	936.00	2060.00	5000.0	1342.02	1201.06
DOSE	308	118	151.0	574.75	1151.50	2455.00	16541.0	1619.45	1591.04
ESCAPE	433	74	0.0	221.50	569.00	1146.00	9514.0	986.47	1299.69
EXACT	253	171	12.0	220.00	397.00	838.00	3035.0	604.83	600.79
FIGHT	300	273	270.0	480.30	901.00	1230.00	2745.9	1036.02	745.96
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	1368	4.0	108.00	244.00	536.50	4464.5	461.74	634.60
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	142	17.7	212.00	289.00	454.50	1227.0	355.43	255.50
ROSE	360	264	51.0	536.50	1025.50	1808.25	28327.0	1639.31	2987.91
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1337	1.0	178.79	289.12	555.69	10004.0	474.33	607.61
TOPCAT	3445	2643	4.0	144.00	247.50	442.75	4943.0	376.09	416.84
Overall	27313	23389	0.0	172.00	335.00	716.00	28327.0	642.04	984.17

Body surface area

Variable used: bsa

Additional label: BSA, m2

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	4	1.46	1.90	2.08	2.28	3.05	2.10	0.27
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	5	1.38	1.87	2.04	2.22	2.89	2.05	0.26
INDIE-HFpEF	105	0	1.43	1.93	2.07	2.23	2.56	2.07	0.24
NEAT-HFpEF	110	0	1.35	1.88	2.09	2.26	3.04	2.09	0.29
RELAX	216	0	1.47	1.87	2.05	2.23	2.66	2.07	0.25
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5458	1.35	1.76	1.91	2.06	2.70	1.91	0.22
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	34	1.20	1.79	1.93	2.08	3.17	1.94	0.22
TOPCAT	3445	10	1.32	1.80	1.95	2.13	2.84	1.97	0.25
Overall	27313	17672	1.20	1.81	1.97	2.14	3.17	1.99	0.25

BUN

Variable used: bun

Additional label: BUN, mg/dL

Study	< 15	15-25	25+	Unknown	Total
ATHENA	78 (21.7%)	147 (40.8%)	135 (37.5%)	0 (0.0%)	360 (100.0%)
CARRESS	2 (1.1%)	12 (6.4%)	174 (92.6%)	0 (0.0%)	188 (100.0%)
DOSE	30 (9.7%)	88 (28.6%)	190 (61.7%)	0 (0.0%)	308 (100.0%)
ESCAPE	47 (10.9%)	136 (31.4%)	246 (56.8%)	4 (0.9%)	433 (100.0%)
EXACT	13 (5.1%)	64 (25.3%)	168 (66.4%)	8 (3.2%)	253 (100.0%)
FIGHT	13 (4.3%)	91 (30.3%)	194 (64.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	205 (22.9%)	304 (34.0%)	338 (37.8%)	47 (5.3%)	894 (100.0%)
HF-ACTION	415 (19.5%)	861 (40.4%)	577 (27.1%)	277 (13.0%)	2,130 (100.0%)
INDIE-HFpEF	19 (18.1%)	54 (51.4%)	31 (29.5%)	1 (1.0%)	105 (100.0%)
NEAT-HFpEF	13 (11.8%)	62 (56.4%)	34 (30.9%)	1 (0.9%)	110 (100.0%)
RELAX	24 (11.1%)	73 (33.8%)	79 (36.6%)	40 (18.5%)	216 (100.0%)
ROSE	7 (1.9%)	64 (17.8%)	287 (79.7%)	2 (0.6%)	360 (100.0%)
SCD-HeFT	563 (22.3%)	1,285 (51.0%)	642 (25.5%)	31 (1.2%)	2,521 (100.0%)
SOLVD Prevent	1,348 (31.9%)	2,501 (59.2%)	319 (7.5%)	60 (1.4%)	4,228 (100.0%)
SOLVD Registry	1,432 (22.8%)	2,937 (46.8%)	1,330 (21.2%)	574 (9.2%)	6,273 (100.0%)
SOLVD Treat	617 (24.0%)	1,475 (57.4%)	422 (16.4%)	55 (2.1%)	2,569 (100.0%)
STICH	384 (14.7%)	802 (30.6%)	920 (35.1%)	514 (19.6%)	2,620 (100.0%)
TOPCAT	677 (19.7%)	1,318 (38.3%)	677 (19.7%)	773 (22.4%)	3,445 (100.0%)
Total	5,887 (21.6%)	12,274 (44.9%)	6,763 (24.8%)	2,389 (8.7%)	27,313 (100.0%)

BUN value

Variable used: bun_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	1.79	16.00	21.50	31.00	101.00	24.39	13.05
CARRESS	188	0	13.00	39.00	50.00	65.05	132.00	54.54	23.47
DOSE	308	0	6.00	20.00	31.00	50.10	108.00	37.38	22.50
ESCAPE	433	4	7.00	19.00	29.00	43.00	129.00	34.89	22.67
EXACT	253	8	6.27	23.00	31.00	41.45	151.25	35.19	18.45
FIGHT	300	2	7.00	22.00	31.00	46.00	159.66	37.48	22.71
GUIDE-IT	894	47	1.71	15.00	22.00	33.78	168.00	26.36	19.63
HF-ACTION	2130	277	0.38	15.00	20.45	28.00	820.00	24.94	27.94
INDIE-HFpEF	105	1	8.00	15.00	20.00	27.25	81.00	23.21	11.56
NEAT-HFpEF	110	1	8.00	17.00	21.00	28.00	100.84	26.29	15.60
RELAX	216	40	8.00	17.00	24.51	33.23	85.00	27.66	14.18
ROSE	360	2	11.00	28.00	37.00	50.92	159.66	42.31	21.50
SCD-HeFT	2521	31	0.40	15.00	19.00	26.00	123.00	22.17	11.84
SOLVD Prevent	4228	60	5.00	14.00	17.00	20.00	49.00	17.34	5.66
SOLVD Registry	6273	574	0.00	14.00	19.00	25.00	200.00	21.74	12.35
SOLVD Treat	2569	55	5.00	15.00	18.00	23.00	49.00	19.52	7.35
STICH	2620	514	0.20	16.25	22.69	36.69	1324.87	30.36	37.80
TOPCAT	3445	773	2.80	14.85	19.00	25.26	114.85	21.26	11.26
Overall	27313	2389	0.00	15.00	19.00	26.00	1324.87	23.28	18.45

Prior CABG

Variable used: cabg

Additional label: CABG

Study	No	Yes	Total
ATHENA	292 (81.1%)	68 (18.9%)	360 (100.0%)
CARRESS	128 (68.1%)	60 (31.9%)	188 (100.0%)
DOSE	210 (68.2%)	98 (31.8%)	308 (100.0%)
ESCAPE	308 (71.1%)	125 (28.9%)	433 (100.0%)
EXACT	178 (70.4%)	75 (29.6%)	253 (100.0%)
FIGHT	216 (72.0%)	84 (28.0%)	300 (100.0%)
GUIDE-IT	741 (82.9%)	153 (17.1%)	894 (100.0%)
HF-ACTION	1,592 (74.7%)	538 (25.3%)	2,130 (100.0%)
INDIE-HFpEF	96 (91.4%)	9 (8.6%)	105 (100.0%)
NEAT-HFpEF	99 (90.0%)	11 (10.0%)	110 (100.0%)
RELAX	182 (84.3%)	34 (15.7%)	216 (100.0%)
ROSE	241 (66.9%)	119 (33.1%)	360 (100.0%)
SCD-HeFT	1,848 (73.3%)	673 (26.7%)	2,521 (100.0%)
SOLVD Prevent	2,784 (65.8%)	1,444 (34.2%)	4,228 (100.0%)
SOLVD Registry	4,889 (77.9%)	1,384 (22.1%)	6,273 (100.0%)
SOLVD Treat	2,019 (78.6%)	550 (21.4%)	2,569 (100.0%)
STICH	2,520 (96.2%)	100 (3.8%)	2,620 (100.0%)
TOPCAT	3,002 (87.1%)	443 (12.9%)	3,445 (100.0%)
Total	21,345 (78.1%)	5,968 (21.9%)	27,313 (100.0%)

On calcium channel blocker

Variable used: cachblk

Additional label: CCB

Study	No	Yes	Unknown	Total
ATHENA	296 (82.2%)	64 (17.8%)	0 (0.0%)	360 (100.0%)
CARRESS	155 (82.4%)	33 (17.6%)	0 (0.0%)	188 (100.0%)
DOSE	258 (83.8%)	50 (16.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	412 (95.2%)	21 (4.8%)	0 (0.0%)	433 (100.0%)
EXACT	239 (94.5%)	14 (5.5%)	0 (0.0%)	253 (100.0%)
FIGHT	283 (94.3%)	17 (5.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	826 (92.4%)	68 (7.6%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,989 (93.4%)	141 (6.6%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	73 (69.5%)	32 (30.5%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	76 (69.1%)	34 (30.9%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	305 (84.7%)	55 (15.3%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,243 (89.0%)	278 (11.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	2,752 (65.1%)	1,476 (34.9%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	4,132 (65.9%)	2,141 (34.1%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	1,773 (69.0%)	796 (31.0%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,151 (62.4%)	1,294 (37.6%)	0 (0.0%)	3,445 (100.0%)
Total	18,179 (66.6%)	6,514 (23.8%)	2,620 (9.6%)	27,313 (100.0%)

Coronary artery disease

Variable used: cad

Additional label: CAD

Study	No	Yes	Total
ATHENA	134 (37.2%)	226 (62.8%)	360 (100.0%)
CARRESS	74 (39.4%)	114 (60.6%)	188 (100.0%)
DOSE	132 (42.9%)	176 (57.1%)	308 (100.0%)
ESCAPE	202 (46.7%)	231 (53.3%)	433 (100.0%)
EXACT	118 (46.6%)	135 (53.4%)	253 (100.0%)
FIGHT	131 (43.7%)	169 (56.3%)	300 (100.0%)
GUIDE-IT	484 (54.1%)	410 (45.9%)	894 (100.0%)
HF-ACTION	889 (41.7%)	1,241 (58.3%)	2,130 (100.0%)
INDIE-HFpEF	32 (30.5%)	73 (69.5%)	105 (100.0%)
NEAT-HFpEF	85 (77.3%)	25 (22.7%)	110 (100.0%)
RELAX	145 (67.1%)	71 (32.9%)	216 (100.0%)
ROSE	151 (41.9%)	209 (58.1%)	360 (100.0%)
SCD-HeFT	994 (39.4%)	1,527 (60.6%)	2,521 (100.0%)
SOLVD Prevent	550 (13.0%)	3,678 (87.0%)	4,228 (100.0%)
SOLVD Registry	1,524 (24.3%)	4,749 (75.7%)	6,273 (100.0%)
SOLVD Treat	587 (22.8%)	1,982 (77.2%)	2,569 (100.0%)
STICH	12 (0.5%)	2,608 (99.5%)	2,620 (100.0%)
TOPCAT	1,422 (41.3%)	2,023 (58.7%)	3,445 (100.0%)
Total	7,666 (28.1%)	19,647 (71.9%)	27,313 (100.0%)

Cancer

Variable used: cancer

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	172 (91.5%)	16 (8.5%)	0 (0.0%)	188 (100.0%)
DOSE	286 (92.9%)	22 (7.1%)	0 (0.0%)	308 (100.0%)
ESCAPE	403 (93.1%)	30 (6.9%)	0 (0.0%)	433 (100.0%)
EXACT	238 (94.1%)	15 (5.9%)	0 (0.0%)	253 (100.0%)
FIGHT	288 (96.0%)	12 (4.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	850 (95.1%)	44 (4.9%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	105 (95.5%)	5 (4.5%)	0 (0.0%)	110 (100.0%)
RELAX	208 (96.3%)	8 (3.7%)	0 (0.0%)	216 (100.0%)
ROSE	338 (93.9%)	22 (6.1%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	6,266 (99.9%)	7 (0.1%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,569 (98.1%)	51 (1.9%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	13,853 (50.7%)	232 (0.8%)	13,228 (48.4%)	27,313 (100.0%)

CES-D10 score

Variable used: cesd10

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	58	10	16	19	24	37	20.16	5.46
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	661	10	17	20	24	40	21.01	5.04
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	24518	10	17	20	24	40	20.75	5.18

CES-D20 score

Variable used: cesd20

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	732	20	33	37	44	80	38.87	8.34
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25425	20	33	37	44	80	38.87	8.34

cGMP value

Variable used: cgmp_val

Additional label: cGMP

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	1	45.14	93.66	120.28	150.47	225.97	122.98	39.58
NEAT-HFpEF	110	1	87.72	159.94	184.68	208.08	273.25	184.96	36.63
RELAX	216	2	14.28	57.46	76.81	101.20	270.72	82.19	37.12
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26886	14.28	72.93	109.52	159.19	273.25	118.36	56.61

Chronic kidney disease stage

Variable used: ckd

Additional label: CKD

Study	Stage 1	Stage 2	Stage 3	Stage 4/5	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	8 (4.3%)	92 (48.9%)	86 (45.7%)	2 (1.1%)	188 (100.0%)
DOSE	23 (7.5%)	74 (24.0%)	172 (55.8%)	39 (12.7%)	0 (0.0%)	308 (100.0%)
ESCAPE	51 (11.8%)	119 (27.5%)	203 (46.9%)	57 (13.2%)	3 (0.7%)	433 (100.0%)
EXACT	18 (7.1%)	72 (28.5%)	143 (56.5%)	20 (7.9%)	0 (0.0%)	253 (100.0%)
FIGHT	23 (7.7%)	77 (25.7%)	163 (54.3%)	35 (11.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	64 (7.2%)	302 (33.8%)	408 (45.6%)	85 (9.5%)	35 (3.9%)	894 (100.0%)
HF-ACTION	304 (14.3%)	866 (40.7%)	674 (31.6%)	68 (3.2%)	218 (10.2%)	2,130 (100.0%)
INDIE-HFpEF	5 (4.8%)	45 (42.9%)	52 (49.5%)	2 (1.9%)	1 (1.0%)	105 (100.0%)
NEAT-HFpEF	6 (5.5%)	44 (40.0%)	54 (49.1%)	5 (4.5%)	1 (0.9%)	110 (100.0%)
RELAX	22 (10.2%)	75 (34.7%)	103 (47.7%)	16 (7.4%)	0 (0.0%)	216 (100.0%)
ROSE	1 (0.3%)	39 (10.8%)	246 (68.3%)	74 (20.6%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,018 (40.4%)	869 (34.5%)	566 (22.5%)	47 (1.9%)	21 (0.8%)	2,521 (100.0%)
SOLVD Prevent	438 (10.4%)	2,400 (56.8%)	1,299 (30.7%)	18 (0.4%)	73 (1.7%)	4,228 (100.0%)
SOLVD Registry	451 (7.2%)	2,443 (38.9%)	2,476 (39.5%)	287 (4.6%)	616 (9.8%)	6,273 (100.0%)
SOLVD Treat	161 (6.3%)	1,144 (44.5%)	1,168 (45.5%)	29 (1.1%)	67 (2.6%)	2,569 (100.0%)
STICH	339 (12.9%)	1,320 (50.4%)	826 (31.5%)	86 (3.3%)	49 (1.9%)	2,620 (100.0%)
TOPCAT	290 (8.4%)	1,550 (45.0%)	1,574 (45.7%)	29 (0.8%)	2 (0.1%)	3,445 (100.0%)
Total	3,214 (11.8%)	11,447 (41.9%)	10,219 (37.4%)	983 (3.6%)	1,450 (5.3%)	27,313 (100.0%)

Chloride value

Variable used: cl

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	76	99	102	105.00	111	101.71	5.15
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	3	87	98	101	103.00	110	100.17	4.52
FIGHT	300	2	79	95	99	102.00	110	98.25	5.43
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	1	88	99	101	103.00	108	101.01	3.43
NEAT-HFpEF	110	2	92	100	103	104.25	111	102.07	3.73
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	2	84	98	101	104.00	117	100.44	5.08
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	124	65	100	103	105.00	140	102.58	5.16
Overall	27313	22514	65	99	102	105.00	140	101.92	5.22

Cardiomyopathy etiology

Variable used: cm_etiology

Additional label: NA

Study	Alcohol	Cocaine	Connective tissue disease	Cytotoxic	Familial	Giant cell myocarditis	Hypertensive	Idiopathic	Ischemic	Multiple	Other	Peripartum	Radiation	Restrictive	Valvular	Unknown	Total
ATHENA	3 (0.8%)	0 (0.0%)	0 (0.0%)	2 (0.6%)	2 (0.6%)	0 (0.0%)	36 (10.0%)	5 (1.4%)	226 (62.8%)	30 (8.3%)	4 (1.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4 (1.1%)	48 (13.3%)	360 (100.0%)
CARRESS	5 (2.7%)	0 (0.0%)	0 (0.0%)	1 (0.5%)	0 (0.0%)	0 (0.0%)	16 (8.5%)	9 (4.8%)	114 (60.6%)	26 (13.8%)	14 (7.4%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (0.5%)	2 (1.1%)	188 (100.0%)
DOSE	9 (2.9%)	0 (0.0%)	0 (0.0%)	2 (0.6%)	1 (0.3%)	0 (0.0%)	10 (3.2%)	38 (12.3%)	176 (57.1%)	27 (8.8%)	21 (6.8%)	2 (0.6%)	0 (0.0%)	2 (0.6%)	20 (6.5%)	0 (0.0%)	308 (100.0%)
ESCAPE	31 (7.2%)	0 (0.0%)	0 (0.0%)	3 (0.7%)	8 (1.8%)	0 (0.0%)	27 (6.2%)	110 (25.4%)	196 (45.3%)	0 (0.0%)	32 (7.4%)	7 (1.6%)	0 (0.0%)	0 (0.0%)	17 (3.9%)	2 (0.5%)	433 (100.0%)
EXACT	6 (2.4%)	0 (0.0%)	0 (0.0%)	4 (1.6%)	2 (0.8%)	0 (0.0%)	15 (5.9%)	39 (15.4%)	135 (53.4%)	30 (11.9%)	8 (3.2%)	0 (0.0%)	0 (0.0%)	2 (0.8%)	12 (4.7%)	0 (0.0%)	253 (100.0%)
FIGHT	2 (0.7%)	0 (0.0%)	0 (0.0%)	3 (1.0%)	1 (0.3%)	0 (0.0%)	11 (3.7%)	6 (2.0%)	246 (82.0%)	12 (4.0%)	4 (1.3%)	1 (0.3%)	0 (0.0%)	0 (0.0%)	1 (0.3%)	13 (4.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	144 (16.1%)	300 (33.6%)	315 (35.2%)	0 (0.0%)	112 (12.5%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	20 (2.2%)	3 (0.3%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	14 (13.3%)	0 (0.0%)	73 (69.5%)	4 (3.8%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	14 (13.3%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (0.9%)	0 (0.0%)	0 (0.0%)	24 (21.8%)	0 (0.0%)	68 (61.8%)	1 (0.9%)	2 (1.8%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (0.9%)	13 (11.8%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	63 (29.2%)	5 (2.3%)	84 (38.9%)	16 (7.4%)	32 (14.8%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	9 (4.2%)	7 (3.2%)	216 (100.0%)
ROSE	4 (1.1%)	0 (0.0%)	0 (0.0%)	4 (1.1%)	1 (0.3%)	0 (0.0%)	25 (6.9%)	27 (7.5%)	159 (44.2%)	0 (0.0%)	24 (6.7%)	0 (0.0%)	0 (0.0%)	4 (1.1%)	15 (4.2%)	97 (26.9%)	360 (100.0%)
SCD-HeFT	81 (3.2%)	4 (0.2%)	1 (0.0%)	7 (0.3%)	11 (0.4%)	1 (0.0%)	0 (0.0%)	933 (37.0%)	1,305 (51.8%)	0 (0.0%)	162 (6.4%)	8 (0.3%)	1 (0.0%)	0 (0.0%)	7 (0.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	14 (0.2%)	447 (7.1%)	808 (12.9%)	4,312 (68.7%)	0 (0.0%)	235 (3.7%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	456 (7.3%)	1 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,608 (99.5%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	12 (0.5%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	141 (0.5%)	4 (0.0%)	1 (0.0%)	27 (0.1%)	26 (0.1%)	15 (0.1%)	832 (3.0%)	2,280 (8.3%)	10,017 (36.7%)	146 (0.5%)	650 (2.4%)	18 (0.1%)	1 (0.0%)	8 (0.0%)	563 (2.1%)	12,584 (46.1%)	27,313 (100.0%)

COPD

Variable used: copd

Additional label: COPD

Study	No	Yes	Unknown	Total
ATHENA	278 (77.2%)	82 (22.8%)	0 (0.0%)	360 (100.0%)
CARRESS	123 (65.4%)	65 (34.6%)	0 (0.0%)	188 (100.0%)
DOSE	233 (75.6%)	75 (24.4%)	0 (0.0%)	308 (100.0%)
ESCAPE	361 (83.4%)	72 (16.6%)	0 (0.0%)	433 (100.0%)
EXACT	208 (82.2%)	45 (17.8%)	0 (0.0%)	253 (100.0%)
FIGHT	237 (79.0%)	63 (21.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	701 (78.4%)	193 (21.6%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,898 (89.1%)	232 (10.9%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	92 (87.6%)	13 (12.4%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	94 (85.5%)	16 (14.5%)	0 (0.0%)	110 (100.0%)
RELAX	174 (80.6%)	42 (19.4%)	0 (0.0%)	216 (100.0%)
ROSE	265 (73.6%)	95 (26.4%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	4,002 (94.7%)	226 (5.3%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	5,335 (85.0%)	938 (15.0%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	2,312 (90.0%)	257 (10.0%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	3,042 (88.3%)	403 (11.7%)	0 (0.0%)	3,445 (100.0%)
Total	19,355 (70.9%)	2,817 (10.3%)	5,141 (18.8%)	27,313 (100.0%)

Country

Variable used: country

Additional label: NA

Study	Argentina	Brazil	Canada	Republic of Georgia	Russia	United States	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	0 (0.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	123 (3.6%)	167 (4.8%)	326 (9.5%)	612 (17.8%)	1,066 (30.9%)	1,151 (33.4%)	0 (0.0%)	3,445 (100.0%)
Total	123 (0.5%)	167 (0.6%)	326 (1.2%)	612 (2.2%)	1,066 (3.9%)	3,098 (11.3%)	21,921 (80.3%)	27,313 (100.0%)

Creatinine value

Variable used: cr_val

Additional label: Creatinine, mg/dL

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	0.40	1.00	1.23	1.50	2.51	1.28	0.38
CARRESS	188	2	1.00	1.74	2.18	2.67	3.53	2.21	0.56
DOSE	308	0	0.59	1.15	1.50	1.90	2.90	1.56	0.51
ESCAPE	433	1	0.50	1.10	1.40	1.80	5.37	1.51	0.62
EXACT	253	0	0.58	1.19	1.49	1.80	3.01	1.53	0.46
FIGHT	300	2	0.60	1.14	1.47	1.86	3.11	1.56	0.54
GUIDE-IT	894	31	0.40	1.05	1.30	1.70	6.65	1.45	0.64
HF-ACTION	2130	218	0.30	1.00	1.20	1.50	13.40	1.33	0.83
INDIE-HFpEF	105	1	17.90	46.22	59.55	72.50	166.30	60.10	20.72
NEAT-HFpEF	110	1	0.57	0.87	1.10	1.33	2.51	1.16	0.39
RELAX	216	0	0.50	0.93	1.20	1.50	3.01	1.28	0.47
ROSE	360	0	0.90	1.40	1.70	2.08	3.80	1.81	0.59
SCD-HeFT	2521	21	0.40	0.90	1.10	1.36	27.00	1.21	0.65
SOLVD Prevent	4228	70	0.50	1.00	1.10	1.30	2.40	1.15	0.26
SOLVD Registry	6273	605	0.00	1.00	1.20	1.40	9.80	1.28	0.52
SOLVD Treat	2569	67	0.50	1.00	1.20	1.40	2.40	1.24	0.31
STICH	2620	40	0.00	0.93	1.10	1.30	133.00	1.28	3.11
TOPCAT	3445	2	0.30	0.90	1.04	1.24	3.00	1.09	0.30
Overall	27313	1061	0.00	1.00	1.18	1.40	166.30	1.49	4.07

Creatinine clearance

Variable used: crcl

Additional label: CrCl

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	2	14.44	25.26	31.02	40.24	80.87	33.97	11.93
DOSE	308	0	18.58	36.15	50.49	67.17	163.22	54.20	24.12
ESCAPE	433	3	0.00	38.32	52.60	71.33	141.90	56.28	26.29
EXACT	253	0	21.76	39.84	51.98	69.32	133.94	56.15	21.66
FIGHT	300	2	19.80	36.42	49.65	66.40	145.80	54.11	22.91
GUIDE-IT	894	35	6.90	40.30	55.70	71.60	233.80	57.60	23.90
HF-ACTION	2130	218	3.99	50.69	66.33	81.34	241.35	67.73	24.42
INDIE-HFpEF	105	1	17.90	46.22	59.55	72.50	166.30	60.10	20.72
NEAT-HFpEF	110	1	25.60	44.20	56.60	76.40	119.80	59.67	19.87
RELAX	216	0	20.95	42.52	57.23	74.53	129.48	59.89	22.06
ROSE	360	0	16.68	32.16	41.55	53.22	99.00	42.68	13.68
SCD-HeFT	2521	21	4.62	60.50	82.20	107.91	320.13	87.65	38.67
SOLVD Prevent	4228	73	19.80	55.90	67.20	77.90	185.10	68.62	18.29
SOLVD Registry	6273	614	4.00	47.30	60.20	73.75	Inf	Inf	NaN
SOLVD Treat	2569	67	21.70	50.10	60.60	73.70	166.90	62.61	18.37
STICH	2620	49	0.30	54.00	66.70	79.30	99664.70	106.68	1964.38
TOPCAT	3445	2	23.20	50.50	61.50	74.40	271.50	63.58	18.93
Overall	27313	1448	0.00	49.80	62.90	77.40	Inf	Inf	NaN

Creatinine clearance < 30

Variable used: crcl_30

Additional label: CrCl < 30

Study	< 30	> 30	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	86 (45.7%)	100 (53.2%)	2 (1.1%)	188 (100.0%)
DOSE	39 (12.7%)	269 (87.3%)	0 (0.0%)	308 (100.0%)
ESCAPE	57 (13.2%)	373 (86.1%)	3 (0.7%)	433 (100.0%)
EXACT	20 (7.9%)	233 (92.1%)	0 (0.0%)	253 (100.0%)
FIGHT	35 (11.7%)	263 (87.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	85 (9.5%)	774 (86.6%)	35 (3.9%)	894 (100.0%)
HF-ACTION	68 (3.2%)	1,844 (86.6%)	218 (10.2%)	2,130 (100.0%)
INDIE-HFpEF	2 (1.9%)	102 (97.1%)	1 (1.0%)	105 (100.0%)
NEAT-HFpEF	5 (4.5%)	104 (94.5%)	1 (0.9%)	110 (100.0%)
RELAX	16 (7.4%)	200 (92.6%)	0 (0.0%)	216 (100.0%)
ROSE	74 (20.6%)	286 (79.4%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	47 (1.9%)	2,453 (97.3%)	21 (0.8%)	2,521 (100.0%)
SOLVD Prevent	18 (0.4%)	4,137 (97.8%)	73 (1.7%)	4,228 (100.0%)
SOLVD Registry	287 (4.6%)	5,370 (85.6%)	616 (9.8%)	6,273 (100.0%)
SOLVD Treat	29 (1.1%)	2,473 (96.3%)	67 (2.6%)	2,569 (100.0%)
STICH	86 (3.3%)	2,485 (94.8%)	49 (1.9%)	2,620 (100.0%)
TOPCAT	29 (0.8%)	3,414 (99.1%)	2 (0.1%)	3,445 (100.0%)
Total	983 (3.6%)	24,880 (91.1%)	1,450 (5.3%)	27,313 (100.0%)

C-reactive protein value

Variable used: crp_val

Additional label: CRP

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	0.58	6.81	16.10	36.15	394	28.72	42.66
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	2	0.16	1.83	3.69	8.09	44	5.99	6.44
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26917	0.16	2.86	7.27	16.65	394	16.44	31.38

Cardiac resynchronization therapy

Variable used: crt

Additional label: CRT

Study	No	Yes	Unknown	Total
ATHENA	268 (74.4%)	92 (25.6%)	0 (0.0%)	360 (100.0%)
CARRESS	158 (84.0%)	30 (16.0%)	0 (0.0%)	188 (100.0%)
DOSE	249 (80.8%)	59 (19.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	174 (68.8%)	79 (31.2%)	0 (0.0%)	253 (100.0%)
FIGHT	191 (63.7%)	109 (36.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	731 (81.8%)	163 (18.2%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,734 (81.4%)	396 (18.6%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	104 (99.0%)	1 (1.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	109 (99.1%)	1 (0.9%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	266 (73.9%)	94 (26.1%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,603 (99.4%)	17 (0.6%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	6,803 (24.9%)	1,041 (3.8%)	19,469 (71.3%)	27,313 (100.0%)

Current smoker

Variable used: cur_smoke

Additional label: Active smoker

Study	No	Yes	Unknown	Total
ATHENA	293 (81.4%)	56 (15.6%)	11 (3.1%)	360 (100.0%)
CARRESS	168 (89.4%)	20 (10.6%)	0 (0.0%)	188 (100.0%)
DOSE	267 (86.7%)	41 (13.3%)	0 (0.0%)	308 (100.0%)
ESCAPE	375 (86.6%)	52 (12.0%)	6 (1.4%)	433 (100.0%)
EXACT	216 (85.4%)	37 (14.6%)	0 (0.0%)	253 (100.0%)
FIGHT	268 (89.3%)	22 (7.3%)	10 (3.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	1,758 (82.5%)	362 (17.0%)	10 (0.5%)	2,130 (100.0%)
INDIE-HFpEF	104 (99.0%)	1 (1.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	105 (95.5%)	2 (1.8%)	3 (2.7%)	110 (100.0%)
RELAX	184 (85.2%)	31 (14.4%)	1 (0.5%)	216 (100.0%)
ROSE	316 (87.8%)	44 (12.2%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,114 (83.9%)	406 (16.1%)	1 (0.0%)	2,521 (100.0%)
SOLVD Prevent	877 (20.7%)	3,341 (79.0%)	10 (0.2%)	4,228 (100.0%)
SOLVD Registry	2,597 (41.4%)	1,289 (20.5%)	2,387 (38.1%)	6,273 (100.0%)
SOLVD Treat	594 (23.1%)	1,972 (76.8%)	3 (0.1%)	2,569 (100.0%)
STICH	2,072 (79.1%)	540 (20.6%)	8 (0.3%)	2,620 (100.0%)
TOPCAT	3,081 (89.4%)	360 (10.4%)	4 (0.1%)	3,445 (100.0%)
Total	15,389 (56.3%)	8,576 (31.4%)	3,348 (12.3%)	27,313 (100.0%)

Cystatin C value

Variable used: cystc_val

Additional label: cystatin C

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	1.03	1.77	2.17	2.65	4.86	2.23	0.63
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	8	0.61	1.05	1.40	1.80	3.80	1.48	0.54
FIGHT	300	10	0.32	1.10	1.38	1.79	4.49	1.51	0.58
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	1	0.05	0.98	1.23	1.61	2.77	1.34	0.49
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	2	0.68	1.07	1.31	1.74	3.14	1.45	0.52
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26278	0.05	1.12	1.48	1.95	4.86	1.60	0.63

On daily furosemide equivalent

Variable used: daily_furo

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	0	0	0	0	0	0.00	0.00
CARRESS	188	0	0	80	120	180	800	152.28	140.26
DOSE	308	0	40	80	120	160	6400	176.86	483.49
ESCAPE	433	0	0	60	120	160	600	138.91	111.45
EXACT	253	0	0	80	120	160	3200	141.36	214.87
FIGHT	300	0	0	80	80	160	560	118.73	84.77
GUIDE-IT	894	0	0	40	40	80	800	71.64	73.94
HF-ACTION	2130	0	0	20	40	80	32000	288.97	1501.73
INDIE-HFpEF	105	0	0	20	20	80	420	54.76	72.13
NEAT-HFpEF	110	0	0	0	20	80	4000	199.05	616.58
RELAX	216	0	0	0	0	0	0	0.00	0.00
ROSE	360	0	0	40	80	160	800	119.26	123.34
SCD-HeFT	2521	0	0	0	0	0	0	0.00	0.00
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	0	0	0	0	0	800	11.99	41.01
Overall	27313	15690	0	0	0	60	32000	86.56	661.87

Diastolic blood pressure

Variable used: dbp

Additional label: NA

Study	< 60	60-80	80+	Unknown	Total
ATHENA	64 (17.8%)	167 (46.4%)	127 (35.3%)	2 (0.6%)	360 (100.0%)
CARRESS	65 (34.6%)	93 (49.5%)	29 (15.4%)	1 (0.5%)	188 (100.0%)
DOSE	80 (26.0%)	154 (50.0%)	73 (23.7%)	1 (0.3%)	308 (100.0%)
ESCAPE	103 (23.8%)	258 (59.6%)	69 (15.9%)	3 (0.7%)	433 (100.0%)
EXACT	63 (24.9%)	144 (56.9%)	46 (18.2%)	0 (0.0%)	253 (100.0%)
FIGHT	77 (25.7%)	172 (57.3%)	49 (16.3%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	160 (17.9%)	500 (55.9%)	229 (25.6%)	5 (0.6%)	894 (100.0%)
HF-ACTION	273 (12.8%)	1,332 (62.5%)	520 (24.4%)	5 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	8 (7.6%)	64 (61.0%)	33 (31.4%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	13 (11.8%)	70 (63.6%)	27 (24.5%)	0 (0.0%)	110 (100.0%)
RELAX	27 (12.5%)	140 (64.8%)	49 (22.7%)	0 (0.0%)	216 (100.0%)
ROSE	95 (26.4%)	222 (61.7%)	43 (11.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	257 (10.2%)	1,578 (62.6%)	677 (26.9%)	9 (0.4%)	2,521 (100.0%)
SOLVD Prevent	53 (1.3%)	1,929 (45.6%)	2,239 (53.0%)	7 (0.2%)	4,228 (100.0%)
SOLVD Registry	210 (3.3%)	2,859 (45.6%)	2,985 (47.6%)	219 (3.5%)	6,273 (100.0%)
SOLVD Treat	73 (2.8%)	1,266 (49.3%)	1,223 (47.6%)	7 (0.3%)	2,569 (100.0%)
STICH	184 (7.0%)	1,312 (50.1%)	1,108 (42.3%)	16 (0.6%)	2,620 (100.0%)
TOPCAT	231 (6.7%)	1,410 (40.9%)	1,800 (52.2%)	4 (0.1%)	3,445 (100.0%)
Total	2,036 (7.5%)	13,670 (50.0%)	11,326 (41.5%)	281 (1.0%)	27,313 (100.0%)

Diastolic blood pressure value

Variable used: dbp_val

Additional label: DBP, mm Hg

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	2	36	62.0	72.0	84.0	128	74.23	16.62
CARRESS	188	1	30	55.5	64.0	72.5	108	64.83	13.13
DOSE	308	1	30	59.0	68.0	78.0	128	69.06	14.18
ESCAPE	433	3	34	60.0	67.0	74.0	99	66.72	11.52
EXACT	253	0	40	60.0	67.0	75.0	98	67.49	11.80
FIGHT	300	2	43	59.0	66.5	75.0	101	67.32	10.83
GUIDE-IT	894	5	0	61.0	70.0	80.0	144	70.93	13.70
HF-ACTION	2130	5	35	60.0	70.0	78.0	118	70.21	11.30
INDIE-HFpEF	105	0	51	66.0	72.0	81.0	96	73.03	10.14
NEAT-HFpEF	110	0	53	62.0	71.5	78.0	93	71.40	9.99
RELAX	216	0	41	62.0	70.0	78.0	98	70.05	10.36
ROSE	360	0	35	59.0	65.0	72.0	109	66.36	11.41
SCD-HeFT	2521	9	38	62.0	70.0	80.0	114	71.12	11.39
SOLVD Prevent	4228	7	50	70.0	80.0	84.0	110	77.96	9.56
SOLVD Registry	6273	219	20	70.0	78.0	84.0	158	77.01	12.66
SOLVD Treat	2569	7	50	70.0	78.0	84.0	110	76.83	10.20
STICH	2620	16	30	66.0	72.5	80.0	140	73.64	11.53
TOPCAT	3445	4	41	70.0	80.0	80.0	108	75.77	10.65
Overall	27313	281	0	68.0	74.0	80.0	158	74.57	11.91

Diastolic dysfunction

Variable used: dd

Additional label: Diastolic dysfunction

Study	Grade I	Grade II	Grade III	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	84 (2.4%)	126 (3.7%)	29 (0.8%)	114 (3.3%)	3,092 (89.8%)	3,445 (100.0%)
Total	84 (0.3%)	126 (0.5%)	29 (0.1%)	114 (0.4%)	26,960 (98.7%)	27,313 (100.0%)

Diastolic dysfunction Olmsted

Variable used: dd_olm

Additional label: NA

Study	Grade I	Grade II	Grade III	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	101 (2.9%)	122 (3.5%)	49 (1.4%)	26 (0.8%)	3,147 (91.3%)	3,445 (100.0%)
Total	101 (0.4%)	122 (0.4%)	49 (0.2%)	26 (0.1%)	27,015 (98.9%)	27,313 (100.0%)

Mitral E decel time

Variable used: decel_time

Additional label: MV decel time

Study	<150	150-220	220+	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	151 (34.9%)	53 (12.2%)	18 (4.2%)	211 (48.7%)	433 (100.0%)
EXACT	112 (44.3%)	64 (25.3%)	21 (8.3%)	56 (22.1%)	253 (100.0%)
FIGHT	126 (42.0%)	105 (35.0%)	13 (4.3%)	56 (18.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	392 (18.4%)	628 (29.5%)	453 (21.3%)	657 (30.8%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	5 (4.5%)	48 (43.6%)	54 (49.1%)	3 (2.7%)	110 (100.0%)
RELAX	37 (17.1%)	112 (51.9%)	44 (20.4%)	23 (10.6%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	136 (2.2%)	67 (1.1%)	77 (1.2%)	5,993 (95.5%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	413 (15.8%)	727 (27.7%)	353 (13.5%)	1,127 (43.0%)	2,620 (100.0%)
TOPCAT	71 (2.1%)	265 (7.7%)	183 (5.3%)	2,926 (84.9%)	3,445 (100.0%)
Total	1,443 (5.3%)	2,069 (7.6%)	1,216 (4.5%)	22,585 (82.7%)	27,313 (100.0%)

Mitral E decel time value

Variable used: decel_time_val

Additional label: MV decel time

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	211	30.5	109.50	131.17	159.83	484.33	143.42	56.81
EXACT	253	56	54.0	120.00	145.00	177.00	368.00	155.11	51.15
FIGHT	300	56	66.0	123.75	148.50	170.00	359.00	151.82	42.27
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	657	63.0	148.00	188.00	232.00	646.00	197.65	72.47
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	3	100.0	183.33	220.33	256.67	383.33	223.52	56.73
RELAX	216	23	99.0	155.00	185.00	218.00	400.00	191.53	48.39
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5993	42.0	107.00	152.00	228.25	696.00	180.41	108.02
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1127	61.0	146.00	179.00	219.00	441.00	186.24	56.24
TOPCAT	3445	2926	70.0	170.00	205.00	243.33	700.00	211.62	66.99
Overall	27313	22585	30.5	142.00	179.00	223.00	700.00	188.21	68.28

Depression

Variable used: dep

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	303 (84.2%)	57 (15.8%)	0 (0.0%)	360 (100.0%)
CARRESS	143 (76.1%)	45 (23.9%)	0 (0.0%)	188 (100.0%)
DOSE	308 (100.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	350 (80.8%)	83 (19.2%)	0 (0.0%)	433 (100.0%)
EXACT	201 (79.4%)	52 (20.6%)	0 (0.0%)	253 (100.0%)
FIGHT	251 (83.7%)	49 (16.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	753 (84.2%)	141 (15.8%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,678 (78.8%)	452 (21.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	82 (78.1%)	23 (21.9%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	74 (67.3%)	36 (32.7%)	0 (0.0%)	110 (100.0%)
RELAX	149 (69.0%)	67 (31.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,433 (92.9%)	187 (7.1%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	6,725 (24.6%)	1,192 (4.4%)	19,396 (71.0%)	27,313 (100.0%)

On digoxin

Variable used: digoxin

Additional label: Digoxin

Study	No	Yes	Total
ATHENA	323 (89.7%)	37 (10.3%)	360 (100.0%)
CARRESS	153 (81.4%)	35 (18.6%)	188 (100.0%)
DOSE	216 (70.1%)	92 (29.9%)	308 (100.0%)
ESCAPE	118 (27.3%)	315 (72.7%)	433 (100.0%)
EXACT	145 (57.3%)	108 (42.7%)	253 (100.0%)
FIGHT	198 (66.0%)	102 (34.0%)	300 (100.0%)
GUIDE-IT	708 (79.2%)	186 (20.8%)	894 (100.0%)
HF-ACTION	1,166 (54.7%)	964 (45.3%)	2,130 (100.0%)
INDIE-HFpEF	103 (98.1%)	2 (1.9%)	105 (100.0%)
NEAT-HFpEF	106 (96.4%)	4 (3.6%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	216 (100.0%)
ROSE	271 (75.3%)	89 (24.7%)	360 (100.0%)
SCD-HeFT	766 (30.4%)	1,755 (69.6%)	2,521 (100.0%)
SOLVD Prevent	3,700 (87.5%)	528 (12.5%)	4,228 (100.0%)
SOLVD Registry	3,544 (56.5%)	2,729 (43.5%)	6,273 (100.0%)
SOLVD Treat	848 (33.0%)	1,721 (67.0%)	2,569 (100.0%)
STICH	2,095 (80.0%)	525 (20.0%)	2,620 (100.0%)
TOPCAT	3,103 (90.1%)	342 (9.9%)	3,445 (100.0%)
Total	17,779 (65.1%)	9,534 (34.9%)	27,313 (100.0%)

Diabetes mellitus

Variable used: dm

Additional label: DM

Study	No	Yes	Total
ATHENA	214 (59.4%)	146 (40.6%)	360 (100.0%)
CARRESS	64 (34.0%)	124 (66.0%)	188 (100.0%)
DOSE	150 (48.7%)	158 (51.3%)	308 (100.0%)
ESCAPE	293 (67.7%)	140 (32.3%)	433 (100.0%)
EXACT	115 (45.5%)	138 (54.5%)	253 (100.0%)
FIGHT	122 (40.7%)	178 (59.3%)	300 (100.0%)
GUIDE-IT	484 (54.1%)	410 (45.9%)	894 (100.0%)
HF-ACTION	1,452 (68.2%)	678 (31.8%)	2,130 (100.0%)
INDIE-HFpEF	68 (64.8%)	37 (35.2%)	105 (100.0%)
NEAT-HFpEF	67 (60.9%)	43 (39.1%)	110 (100.0%)
RELAX	123 (56.9%)	93 (43.1%)	216 (100.0%)
ROSE	160 (44.4%)	200 (55.6%)	360 (100.0%)
SCD-HeFT	1,754 (69.6%)	767 (30.4%)	2,521 (100.0%)
SOLVD Prevent	3,581 (84.7%)	647 (15.3%)	4,228 (100.0%)
SOLVD Registry	4,850 (77.3%)	1,423 (22.7%)	6,273 (100.0%)
SOLVD Treat	1,906 (74.2%)	663 (25.8%)	2,569 (100.0%)
STICH	1,624 (62.0%)	996 (38.0%)	2,620 (100.0%)
TOPCAT	2,327 (67.5%)	1,118 (32.5%)	3,445 (100.0%)
Total	19,354 (70.9%)	7,959 (29.1%)	27,313 (100.0%)

Diabetes mellitus type

Variable used: dm_type

Additional label: NA

Study	Insulin dependent	Noninsulin dependent	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	81 (43.1%)	107 (56.9%)	0 (0.0%)	188 (100.0%)
DOSE	89 (28.9%)	219 (71.1%)	0 (0.0%)	308 (100.0%)
ESCAPE	78 (18.0%)	355 (82.0%)	0 (0.0%)	433 (100.0%)
EXACT	64 (25.3%)	189 (74.7%)	0 (0.0%)	253 (100.0%)
FIGHT	107 (35.7%)	193 (64.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	165 (18.5%)	729 (81.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	298 (14.0%)	1,832 (86.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	20 (18.2%)	90 (81.8%)	0 (0.0%)	110 (100.0%)
RELAX	39 (18.1%)	177 (81.9%)	0 (0.0%)	216 (100.0%)
ROSE	124 (34.4%)	236 (65.6%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	293 (11.6%)	2,228 (88.4%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	496 (7.9%)	5,777 (92.1%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	434 (16.6%)	2,186 (83.4%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	691 (20.1%)	2,754 (79.9%)	0 (0.0%)	3,445 (100.0%)
Total	2,979 (10.9%)	17,072 (62.5%)	7,262 (26.6%)	27,313 (100.0%)

Dyspnea for congestion score

Variable used: dyspnea_ccs

Additional label: NA

Study	0	1	2	3	Unknown	Total
ATHENA	8 (2.2%)	42 (11.7%)	224 (62.2%)	83 (23.1%)	3 (0.8%)	360 (100.0%)
CARRESS	44 (23.4%)	51 (27.1%)	56 (29.8%)	36 (19.1%)	1 (0.5%)	188 (100.0%)
DOSE	61 (19.8%)	80 (26.0%)	95 (30.8%)	70 (22.7%)	2 (0.6%)	308 (100.0%)
ESCAPE	4 (0.9%)	45 (10.4%)	139 (32.1%)	241 (55.7%)	4 (0.9%)	433 (100.0%)
EXACT	55 (21.7%)	97 (38.3%)	72 (28.5%)	29 (11.5%)	0 (0.0%)	253 (100.0%)
FIGHT	31 (10.3%)	87 (29.0%)	126 (42.0%)	51 (17.0%)	5 (1.7%)	300 (100.0%)
GUIDE-IT	192 (21.5%)	334 (37.4%)	260 (29.1%)	93 (10.4%)	15 (1.7%)	894 (100.0%)
HF-ACTION	556 (26.1%)	963 (45.2%)	541 (25.4%)	61 (2.9%)	9 (0.4%)	2,130 (100.0%)
INDIE-HFpEF	7 (6.7%)	35 (33.3%)	51 (48.6%)	12 (11.4%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	14 (12.7%)	36 (32.7%)	44 (40.0%)	13 (11.8%)	3 (2.7%)	110 (100.0%)
RELAX	10 (4.6%)	47 (21.8%)	83 (38.4%)	76 (35.2%)	0 (0.0%)	216 (100.0%)
ROSE	108 (30.0%)	101 (28.1%)	89 (24.7%)	53 (14.7%)	9 (2.5%)	360 (100.0%)
SCD-HeFT	321 (12.7%)	754 (29.9%)	885 (35.1%)	501 (19.9%)	60 (2.4%)	2,521 (100.0%)
SOLVD Prevent	226 (5.3%)	1,090 (25.8%)	0 (0.0%)	0 (0.0%)	2,912 (68.9%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	801 (31.2%)	840 (32.7%)	928 (36.1%)	2,569 (100.0%)
STICH	619 (23.6%)	673 (25.7%)	625 (23.9%)	184 (7.0%)	519 (19.8%)	2,620 (100.0%)
TOPCAT	406 (11.8%)	1,280 (37.2%)	1,439 (41.8%)	274 (8.0%)	46 (1.3%)	3,445 (100.0%)
Total	2,662 (9.7%)	5,715 (20.9%)	5,530 (20.2%)	2,617 (9.6%)	10,789 (39.5%)	27,313 (100.0%)

Mitral E/A ratio

Variable used: ea_ratio

Additional label: E/A

Study	Decreased	Increased	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	24 (5.5%)	123 (28.4%)	39 (9.0%)	247 (57.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	20 (6.7%)	81 (27.0%)	61 (20.3%)	138 (46.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	627 (29.4%)	283 (13.3%)	516 (24.2%)	704 (33.1%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	51 (46.4%)	6 (5.5%)	32 (29.1%)	21 (19.1%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	146 (2.3%)	59 (0.9%)	76 (1.2%)	5,992 (95.5%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	737 (28.1%)	277 (10.6%)	519 (19.8%)	1,087 (41.5%)	2,620 (100.0%)
TOPCAT	201 (5.8%)	37 (1.1%)	151 (4.4%)	3,056 (88.7%)	3,445 (100.0%)
Total	1,806 (6.6%)	866 (3.2%)	1,394 (5.1%)	23,247 (85.1%)	27,313 (100.0%)

Mitral E/A ratio value

Variable used: ea_ratio_val

Additional label: E/A ratio

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	247	0.00	1.61	2.49	3.54	11.24	2.64	1.49
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	138	0.40	1.40	2.06	3.00	5.50	2.23	1.12
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	704	0.23	0.74	1.08	1.71	6.79	1.40	0.96
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	21	0.49	0.80	0.93	1.13	3.12	1.08	0.51
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5992	0.25	0.65	0.97	1.82	9.80	1.49	1.35
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1087	0.25	0.67	1.00	1.67	7.00	1.34	0.99
TOPCAT	3445	3056	0.42	0.75	0.97	1.41	4.00	1.18	0.61
Overall	27313	23247	0.00	0.72	1.05	1.82	11.24	1.45	1.06

Edema

Variable used: edema

Additional label: Edema

Study	No	Yes	Unknown	Total
ATHENA	166 (46.1%)	194 (53.9%)	0 (0.0%)	360 (100.0%)
CARRESS	21 (11.2%)	167 (88.8%)	0 (0.0%)	188 (100.0%)
DOSE	65 (21.1%)	243 (78.9%)	0 (0.0%)	308 (100.0%)
ESCAPE	287 (66.3%)	146 (33.7%)	0 (0.0%)	433 (100.0%)
EXACT	220 (87.0%)	33 (13.0%)	0 (0.0%)	253 (100.0%)
FIGHT	249 (83.0%)	51 (17.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	755 (84.5%)	139 (15.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	95 (90.5%)	10 (9.5%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	73 (66.4%)	37 (33.6%)	0 (0.0%)	110 (100.0%)
RELAX	172 (79.6%)	44 (20.4%)	0 (0.0%)	216 (100.0%)
ROSE	143 (39.7%)	217 (60.3%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,521 (100.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	4,041 (95.6%)	187 (4.4%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	4,267 (68.0%)	2,006 (32.0%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	2,140 (83.3%)	429 (16.7%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	1,378 (40.0%)	2,067 (60.0%)	0 (0.0%)	3,445 (100.0%)
Total	16,593 (60.8%)	5,970 (21.9%)	4,750 (17.4%)	27,313 (100.0%)

Edema for congestion score

Variable used: edema_ccs

Additional label: NA

Study	0	1	2	3	Unknown	Total
ATHENA	78 (21.7%)	87 (24.2%)	112 (31.1%)	82 (22.8%)	1 (0.3%)	360 (100.0%)
CARRESS	2 (1.1%)	19 (10.1%)	101 (53.7%)	66 (35.1%)	0 (0.0%)	188 (100.0%)
DOSE	14 (4.5%)	51 (16.6%)	150 (48.7%)	93 (30.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	138 (31.9%)	137 (31.6%)	99 (22.9%)	47 (10.9%)	12 (2.8%)	433 (100.0%)
EXACT	163 (64.4%)	55 (21.7%)	23 (9.1%)	10 (4.0%)	2 (0.8%)	253 (100.0%)
FIGHT	0 (0.0%)	126 (42.0%)	119 (39.7%)	51 (17.0%)	4 (1.3%)	300 (100.0%)
GUIDE-IT	499 (55.8%)	245 (27.4%)	121 (13.5%)	18 (2.0%)	11 (1.2%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	53 (50.5%)	27 (25.7%)	10 (9.5%)	0 (0.0%)	15 (14.3%)	105 (100.0%)
NEAT-HFpEF	72 (65.5%)	25 (22.7%)	10 (9.1%)	2 (1.8%)	1 (0.9%)	110 (100.0%)
RELAX	91 (42.1%)	81 (37.5%)	44 (20.4%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	30 (8.3%)	76 (21.1%)	112 (31.1%)	105 (29.2%)	37 (10.3%)	360 (100.0%)
SCD-HeFT	2,051 (81.4%)	376 (14.9%)	75 (3.0%)	10 (0.4%)	9 (0.4%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	4,029 (95.3%)	187 (4.4%)	0 (0.0%)	12 (0.3%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	3,791 (60.4%)	2,006 (32.0%)	0 (0.0%)	476 (7.6%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	2,134 (83.1%)	429 (16.7%)	0 (0.0%)	6 (0.2%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	1,371 (39.8%)	2,067 (60.0%)	0 (0.0%)	7 (0.2%)	3,445 (100.0%)
Total	3,191 (11.7%)	12,630 (46.2%)	5,665 (20.7%)	484 (1.8%)	5,343 (19.6%)	27,313 (100.0%)

Education level

Variable used: educ_level

Additional label: NA

Study	Associate/some college	Bachelors	Graduate	High school	Middle school	Some high school	Technical school	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	59 (13.6%)	26 (6.0%)	180 (41.6%)	32 (7.4%)	65 (15.0%)	27 (6.2%)	44 (10.2%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	753 (35.4%)	325 (15.3%)	177 (8.3%)	573 (26.9%)	0 (0.0%)	255 (12.0%)	0 (0.0%)	47 (2.2%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	335 (7.9%)	235 (5.6%)	144 (3.4%)	823 (19.5%)	461 (10.9%)	480 (11.4%)	0 (0.0%)	1,750 (41.4%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	262 (10.2%)	159 (6.2%)	93 (3.6%)	799 (31.1%)	538 (20.9%)	516 (20.1%)	0 (0.0%)	202 (7.9%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,350 (4.9%)	778 (2.8%)	440 (1.6%)	2,375 (8.7%)	1,031 (3.8%)	1,316 (4.8%)	27 (0.1%)	19,996 (73.2%)	27,313 (100.0%)

Education level simple

Variable used: educ_level_simple

Additional label: NA

Study	Basic	High school	Higher learning	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	97 (22.4%)	180 (41.6%)	112 (25.9%)	44 (10.2%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	255 (12.0%)	573 (26.9%)	1,255 (58.9%)	47 (2.2%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	941 (22.3%)	823 (19.5%)	714 (16.9%)	1,750 (41.4%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	1,054 (41.0%)	799 (31.1%)	514 (20.0%)	202 (7.9%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,347 (8.6%)	2,375 (8.7%)	2,595 (9.5%)	19,996 (73.2%)	27,313 (100.0%)

E/e prime avg

Variable used: eeprime_avg

Additional label: E/e’ average

Study	Elevated	Indeterminate	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	109 (43.1%)	49 (19.4%)	5 (2.0%)	90 (35.6%)	253 (100.0%)
FIGHT	175 (58.3%)	44 (14.7%)	4 (1.3%)	77 (25.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	223 (10.5%)	313 (14.7%)	272 (12.8%)	1,322 (62.1%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	29 (26.4%)	56 (50.9%)	16 (14.5%)	9 (8.2%)	110 (100.0%)
RELAX	84 (38.9%)	83 (38.4%)	14 (6.5%)	35 (16.2%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	446 (17.0%)	409 (15.6%)	65 (2.5%)	1,700 (64.9%)	2,620 (100.0%)
TOPCAT	89 (2.6%)	179 (5.2%)	41 (1.2%)	3,136 (91.0%)	3,445 (100.0%)
Total	1,155 (4.2%)	1,133 (4.1%)	417 (1.5%)	24,608 (90.1%)	27,313 (100.0%)

E/e prime avg value

Variable used: eeprime_avg_val

Additional label: E/e’ average,

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	90	4.00	13.50	18.00	23.95	50.00	20.10	9.07
FIGHT	300	77	5.70	15.65	20.10	25.90	62.50	21.50	8.52
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	1322	0.11	6.69	10.39	15.60	55.49	11.92	7.92
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	9	3.73	9.30	12.15	16.20	49.12	13.95	7.69
RELAX	216	35	5.20	10.10	14.00	20.10	75.00	16.42	8.77
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1700	2.50	11.43	15.00	21.16	80.00	17.62	9.63
TOPCAT	3445	3136	4.99	9.26	12.30	15.32	43.56	13.36	5.80
Overall	27313	24608	0.11	9.82	13.90	20.00	80.00	15.68	9.08

E/e prime lateral

Variable used: eeprime_lat

Additional label: E/e’ lateral

Study	Elevated	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	119 (47.0%)	60 (23.7%)	74 (29.2%)	253 (100.0%)
FIGHT	179 (59.7%)	60 (20.0%)	61 (20.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	276 (13.0%)	647 (30.4%)	1,207 (56.7%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	35 (31.8%)	66 (60.0%)	9 (8.2%)	110 (100.0%)
RELAX	91 (42.1%)	94 (43.5%)	31 (14.4%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	437 (16.7%)	465 (17.7%)	1,718 (65.6%)	2,620 (100.0%)
TOPCAT	130 (3.8%)	237 (6.9%)	3,078 (89.3%)	3,445 (100.0%)
Total	1,267 (4.6%)	1,629 (6.0%)	24,417 (89.4%)	27,313 (100.0%)

E/e prime lateral value

Variable used: eeprime_lat_val

Additional label: E/e’ lateral

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	74	3.00	10.00	15.00	20.85	80.00	17.04	9.85
FIGHT	300	61	3.80	12.10	16.20	22.50	65.00	18.62	9.17
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	1207	0.11	5.25	8.35	13.03	55.63	10.13	7.64
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	9	2.80	7.62	10.44	14.71	73.00	12.86	9.08
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1718	1.80	8.30	12.00	16.70	120.00	13.71	8.56
TOPCAT	3445	3078	2.98	7.83	10.21	13.89	47.65	11.58	5.83
Overall	27313	24602	0.11	7.36	11.10	16.00	120.00	12.82	8.53

E/e prime medial

Variable used: eeprime_med

Additional label: E/e’ septal

Study	Elevated	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	138 (54.5%)	48 (19.0%)	67 (26.5%)	253 (100.0%)
FIGHT	194 (64.7%)	36 (12.0%)	70 (23.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	301 (14.1%)	602 (28.3%)	1,227 (57.6%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	36 (32.7%)	68 (61.8%)	6 (5.5%)	110 (100.0%)
RELAX	101 (46.8%)	87 (40.3%)	28 (13.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	447 (17.1%)	473 (18.1%)	1,700 (64.9%)	2,620 (100.0%)
TOPCAT	163 (4.7%)	210 (6.1%)	3,072 (89.2%)	3,445 (100.0%)
Total	1,380 (5.1%)	1,524 (5.6%)	24,409 (89.4%)	27,313 (100.0%)

E/e prime medial value

Variable used: eeprime_med_val

Additional label: E/e’ septal

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	67	4.30	15.00	22.00	30.00	75.00	23.86	12.36
FIGHT	300	70	5.60	16.80	22.50	30.00	75.00	24.60	10.67
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	1227	0.10	6.93	11.64	17.61	67.24	13.32	9.19
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	6	4.67	9.96	13.50	17.31	65.50	15.00	8.39
RELAX	216	28	5.50	11.40	15.85	22.70	60.00	18.48	9.48
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1700	2.50	11.40	15.00	21.00	85.00	17.65	9.78
TOPCAT	3445	3072	4.69	10.23	14.18	18.34	39.46	15.27	6.66
Overall	27313	24409	0.10	10.00	15.00	21.02	85.00	16.90	10.09

LV ejection fraction

Variable used: ef_cat

Additional label: EF

Study	HFmrEF	HFpEF	HFrEF	Unknown	Total
ATHENA	55 (15.3%)	79 (21.9%)	222 (61.7%)	4 (1.1%)	360 (100.0%)
CARRESS	23 (12.2%)	59 (31.4%)	106 (56.4%)	0 (0.0%)	188 (100.0%)
DOSE	36 (11.7%)	71 (23.1%)	193 (62.7%)	8 (2.6%)	308 (100.0%)
ESCAPE	4 (0.9%)	0 (0.0%)	418 (96.5%)	11 (2.5%)	433 (100.0%)
EXACT	11 (4.3%)	0 (0.0%)	242 (95.7%)	0 (0.0%)	253 (100.0%)
FIGHT	7 (2.3%)	0 (0.0%)	293 (97.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	46 (5.1%)	0 (0.0%)	801 (89.6%)	47 (5.3%)	894 (100.0%)
HF-ACTION	57 (2.7%)	3 (0.1%)	2,066 (97.0%)	4 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	4 (3.8%)	99 (94.3%)	0 (0.0%)	2 (1.9%)	105 (100.0%)
NEAT-HFpEF	3 (2.7%)	106 (96.4%)	1 (0.9%)	0 (0.0%)	110 (100.0%)
RELAX	9 (4.2%)	207 (95.8%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	54 (15.0%)	94 (26.1%)	210 (58.3%)	2 (0.6%)	360 (100.0%)
SCD-HeFT	3 (0.1%)	0 (0.0%)	2,517 (99.8%)	1 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,224 (99.9%)	4 (0.1%)	4,228 (100.0%)
SOLVD Registry	1,244 (19.8%)	0 (0.0%)	4,165 (66.4%)	864 (13.8%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,567 (99.9%)	2 (0.1%)	2,569 (100.0%)
STICH	183 (7.0%)	31 (1.2%)	1,835 (70.0%)	571 (21.8%)	2,620 (100.0%)
TOPCAT	823 (23.9%)	2,621 (76.1%)	0 (0.0%)	1 (0.0%)	3,445 (100.0%)
Total	2,562 (9.4%)	3,370 (12.3%)	19,860 (72.7%)	1,521 (5.6%)	27,313 (100.0%)

LV ejection fraction value

Variable used: ef_val

Additional label: EF, %

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	4	5.0	20.00	33.75	49.00	75.00	34.73	16.62
CARRESS	188	0	10.0	22.00	33.00	55.00	77.00	37.43	17.58
DOSE	308	8	10.0	20.00	30.00	50.00	83.00	34.60	17.53
ESCAPE	433	11	0.0	15.00	20.00	25.00	45.00	19.35	6.58
EXACT	253	0	5.0	18.00	25.00	30.00	40.00	24.53	8.18
FIGHT	300	0	5.0	17.50	23.00	27.00	45.00	22.54	7.66
GUIDE-IT	894	47	4.0	19.50	25.00	30.00	40.00	24.27	8.32
HF-ACTION	2130	4	6.3	20.00	24.76	30.17	55.23	25.21	7.49
INDIE-HFpEF	105	2	50.0	56.00	60.00	65.00	80.00	61.03	5.90
NEAT-HFpEF	110	0	25.0	55.00	61.00	65.00	78.00	60.45	6.47
RELAX	216	0	50.0	55.00	60.00	65.25	83.00	61.31	6.75
ROSE	360	2	10.0	21.25	34.00	53.00	75.00	36.54	16.93
SCD-HeFT	2521	1	5.0	20.00	25.00	30.00	43.00	23.80	6.93
SOLVD Prevent	4228	4	10.0	25.00	30.00	33.00	35.00	28.30	5.61
SOLVD Registry	6273	864	3.0	24.00	32.00	39.00	45.00	30.99	9.17
SOLVD Treat	2569	2	10.0	20.00	25.00	30.00	35.00	24.87	6.68
STICH	2620	571	4.3	21.30	27.20	33.50	74.80	27.89	9.02
TOPCAT	3445	1	44.0	51.00	56.00	61.00	85.00	57.09	7.45
Overall	27313	1521	0.0	22.00	30.00	37.00	85.00	32.14	13.90

LVEF echo value

Variable used: ef_val_echo

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	215	3.47	13.17	18.55	26.16	54.77	20.24	9.55
EXACT	253	6	10.00	20.00	25.00	30.00	55.00	25.79	8.07
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	3	40.00	55.00	60.00	65.00	77.00	60.59	6.39
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	649	8.00	25.00	28.00	35.00	60.00	28.47	7.79
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	24664	3.47	22.00	28.00	35.00	77.00	30.13	12.18

LVEF mri value

Variable used: ef_val_mri

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	99	37.6	57.8	65.8	70.30	81.6	63.67	9.97
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2192	4.3	19.8	26.4	33.52	74.8	27.36	10.92
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26768	4.3	21.7	30.6	44.80	81.6	35.16	18.37

E prime

Variable used: eprime

Additional label: e’

Study	Abnormal	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	552 (25.9%)	287 (13.5%)	1,291 (60.6%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	327 (9.5%)	114 (3.3%)	3,004 (87.2%)	3,445 (100.0%)
Total	879 (3.2%)	401 (1.5%)	26,033 (95.3%)	27,313 (100.0%)

E prime lateral

Variable used: eprime_lat

Additional label: e’ lateral abnormal

Study	Abnormal	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	167 (66.0%)	26 (10.3%)	60 (23.7%)	253 (100.0%)
FIGHT	234 (78.0%)	22 (7.3%)	44 (14.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	652 (30.6%)	412 (19.3%)	1,066 (50.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	77 (70.0%)	25 (22.7%)	8 (7.3%)	110 (100.0%)
RELAX	130 (60.2%)	62 (28.7%)	24 (11.1%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	856 (32.7%)	115 (4.4%)	1,649 (62.9%)	2,620 (100.0%)
TOPCAT	292 (8.5%)	84 (2.4%)	3,069 (89.1%)	3,445 (100.0%)
Total	2,408 (8.8%)	746 (2.7%)	24,159 (88.5%)	27,313 (100.0%)

E prime lateral value

Variable used: eprime_lat_val

Additional label: e’ lateral

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	60	0.02	0.04	0.06	0.08	0.16	0.06	0.03
FIGHT	300	44	1.00	4.00	6.00	7.00	17.00	6.09	2.48
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	1066	1.51	5.78	8.37	12.52	201.08	13.06	15.20
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	8	1.00	6.00	8.00	9.00	17.00	7.83	2.45
RELAX	216	24	2.00	6.00	8.00	10.00	17.00	8.37	3.02
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1649	1.00	4.00	6.00	7.00	19.00	6.07	2.70
TOPCAT	3445	3069	2.43	5.83	7.46	9.62	22.80	8.06	2.92
Overall	27313	24159	0.02	4.50	6.80	9.39	201.08	8.50	9.80

E prime septal

Variable used: eprime_med

Additional label: e’ septal abnormal

Study	Abnormal	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	189 (74.7%)	10 (4.0%)	54 (21.3%)	253 (100.0%)
FIGHT	241 (80.3%)	8 (2.7%)	51 (17.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	727 (34.1%)	315 (14.8%)	1,088 (51.1%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	71 (64.5%)	34 (30.9%)	5 (4.5%)	110 (100.0%)
RELAX	146 (67.6%)	51 (23.6%)	19 (8.8%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	319 (9.3%)	64 (1.9%)	3,062 (88.9%)	3,445 (100.0%)
Total	1,693 (6.2%)	482 (1.8%)	25,138 (92.0%)	27,313 (100.0%)

E prime septal value

Variable used: eprime_med_val

Additional label: e’ septal

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	54	2.00	3.00	4.00	5.00	9.00	4.35	1.61
FIGHT	300	51	1.00	3.00	4.00	5.00	12.00	4.34	1.50
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	1088	1.08	4.22	5.75	9.35	139.13	9.74	12.16
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	5	2.00	5.00	6.00	8.00	15.00	6.40	2.12
RELAX	216	19	2.00	5.00	6.00	8.00	13.00	6.22	2.13
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3062	1.70	4.56	5.62	7.23	15.80	6.06	2.14
Overall	27313	25138	1.00	4.00	5.25	7.36	139.13	7.50	8.82

Euro activity

Variable used: eq5d_activity

Additional label: NA

Study	1	2	3	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	321 (35.9%)	488 (54.6%)	63 (7.0%)	22 (2.5%)	894 (100.0%)
HF-ACTION	1,027 (48.2%)	1,034 (48.5%)	60 (2.8%)	9 (0.4%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	793 (30.3%)	1,046 (39.9%)	209 (8.0%)	572 (21.8%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,141 (7.8%)	2,568 (9.4%)	332 (1.2%)	22,272 (81.5%)	27,313 (100.0%)

Euro mobility

Variable used: eq5d_mobil

Additional label: NA

Study	1	2	3	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	359 (40.2%)	513 (57.4%)	4 (0.4%)	18 (2.0%)	894 (100.0%)
HF-ACTION	1,168 (54.8%)	955 (44.8%)	2 (0.1%)	5 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	954 (36.4%)	1,058 (40.4%)	37 (1.4%)	571 (21.8%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,481 (9.1%)	2,526 (9.2%)	43 (0.2%)	22,263 (81.5%)	27,313 (100.0%)

Euro mood

Variable used: eq5d_mood

Additional label: NA

Study	1	2	3	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	517 (57.8%)	314 (35.1%)	45 (5.0%)	18 (2.0%)	894 (100.0%)
HF-ACTION	1,301 (61.1%)	760 (35.7%)	56 (2.6%)	13 (0.6%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	958 (36.6%)	1,001 (38.2%)	88 (3.4%)	573 (21.9%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,776 (10.2%)	2,075 (7.6%)	189 (0.7%)	22,273 (81.5%)	27,313 (100.0%)

Euro pain

Variable used: eq5d_pain

Additional label: NA

Study	1	2	3	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	399 (44.6%)	410 (45.9%)	66 (7.4%)	19 (2.1%)	894 (100.0%)
HF-ACTION	931 (43.7%)	1,130 (53.1%)	50 (2.3%)	19 (0.9%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	842 (32.1%)	1,117 (42.6%)	84 (3.2%)	577 (22.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,172 (8.0%)	2,657 (9.7%)	200 (0.7%)	22,284 (81.6%)	27,313 (100.0%)

Euro self-care

Variable used: eq5d_selfcare

Additional label: NA

Study	1	2	3	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	698 (78.1%)	164 (18.3%)	13 (1.5%)	19 (2.1%)	894 (100.0%)
HF-ACTION	1,978 (92.9%)	140 (6.6%)	7 (0.3%)	5 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	1,601 (61.1%)	409 (15.6%)	35 (1.3%)	575 (21.9%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	4,277 (15.7%)	713 (2.6%)	55 (0.2%)	22,268 (81.5%)	27,313 (100.0%)

Endothelin-1 value

Variable used: et1_val

Additional label: ET1

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	7	1.47	3.15	4.12	5.58	24.82	4.81	2.83
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	2	0.37	1.95	2.36	3.20	10.87	2.70	1.30
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26918	0.37	2.19	3.12	4.43	24.82	3.67	2.38

Alcohol use

Variable used: etoh

Additional label: EtOH

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	179 (95.2%)	9 (4.8%)	0 (0.0%)	188 (100.0%)
DOSE	279 (90.6%)	29 (9.4%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	223 (88.1%)	30 (11.9%)	0 (0.0%)	253 (100.0%)
FIGHT	279 (93.0%)	21 (7.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	792 (88.6%)	102 (11.4%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	107 (97.3%)	3 (2.7%)	0 (0.0%)	110 (100.0%)
RELAX	204 (94.4%)	12 (5.6%)	0 (0.0%)	216 (100.0%)
ROSE	328 (91.1%)	32 (8.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,092 (83.0%)	429 (17.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	3,622 (85.7%)	606 (14.3%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	5,318 (84.8%)	955 (15.2%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	2,296 (89.4%)	273 (10.6%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,687 (78.0%)	758 (22.0%)	0 (0.0%)	3,445 (100.0%)
Total	20,536 (75.2%)	3,259 (11.9%)	3,518 (12.9%)	27,313 (100.0%)

E wave value

Variable used: ewave_val

Additional label: E wave

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	192	0.00	78.00	94.60	117.00	372.00	98.55	34.47
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	38	30.00	80.00	90.00	110.00	190.00	97.29	27.48
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	707	1.00	55.61	71.54	90.80	226.68	74.14	27.03
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	3	28.00	66.00	81.00	102.50	190.00	86.36	28.88
RELAX	216	17	40.00	80.00	100.00	120.00	210.00	103.12	32.18
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5980	12.00	39.00	51.00	71.00	150.00	55.95	23.21
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	2926	9.13	63.72	80.85	99.87	198.44	83.75	28.33
Overall	27313	24269	0.00	59.25	77.56	99.17	372.00	80.28	30.79

Fatigue for congestion score

Variable used: fatigue_ccs

Additional label: NA

Study	0	1	2	3	Unknown	Total
ATHENA	6 (1.7%)	45 (12.5%)	224 (62.2%)	78 (21.7%)	7 (1.9%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	111 (59.0%)	69 (36.7%)	8 (4.3%)	188 (100.0%)
DOSE	1 (0.3%)	11 (3.6%)	177 (57.5%)	88 (28.6%)	31 (10.1%)	308 (100.0%)
ESCAPE	4 (0.9%)	39 (9.0%)	116 (26.8%)	273 (63.0%)	1 (0.2%)	433 (100.0%)
EXACT	39 (15.4%)	101 (39.9%)	89 (35.2%)	24 (9.5%)	0 (0.0%)	253 (100.0%)
FIGHT	14 (4.7%)	92 (30.7%)	130 (43.3%)	60 (20.0%)	4 (1.3%)	300 (100.0%)
GUIDE-IT	136 (15.2%)	340 (38.0%)	292 (32.7%)	115 (12.9%)	11 (1.2%)	894 (100.0%)
HF-ACTION	414 (19.4%)	984 (46.2%)	601 (28.2%)	123 (5.8%)	8 (0.4%)	2,130 (100.0%)
INDIE-HFpEF	9 (8.6%)	46 (43.8%)	44 (41.9%)	6 (5.7%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	15 (13.6%)	33 (30.0%)	51 (46.4%)	9 (8.2%)	2 (1.8%)	110 (100.0%)
RELAX	9 (4.2%)	45 (20.8%)	99 (45.8%)	62 (28.7%)	1 (0.5%)	216 (100.0%)
ROSE	0 (0.0%)	16 (4.4%)	230 (63.9%)	98 (27.2%)	16 (4.4%)	360 (100.0%)
SCD-HeFT	205 (8.1%)	711 (28.2%)	968 (38.4%)	572 (22.7%)	65 (2.6%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	583 (13.8%)	194 (4.6%)	3,451 (81.6%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	492 (19.2%)	1,366 (53.2%)	0 (0.0%)	0 (0.0%)	711 (27.7%)	2,569 (100.0%)
STICH	498 (19.0%)	651 (24.8%)	695 (26.5%)	256 (9.8%)	520 (19.8%)	2,620 (100.0%)
TOPCAT	308 (8.9%)	1,223 (35.5%)	1,528 (44.4%)	341 (9.9%)	45 (1.3%)	3,445 (100.0%)
Total	2,150 (7.9%)	5,703 (20.9%)	5,938 (21.7%)	2,368 (8.7%)	11,154 (40.8%)	27,313 (100.0%)

Galactin 3

Variable used: galac3_val

Additional label: Galactin 3

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	8	4.19	11.15	13.8	17.81	41.53	15.15	5.95
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	27105	4.19	11.15	13.8	17.81	41.53	15.15	5.95

Global longitudinal strain quartile

Variable used: gls_q

Additional label: GLS quartile

Study	Quartile 1	Quartile 2	Quartile 3	Quartile 4	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	88 (2.6%)	72 (2.1%)	82 (2.4%)	77 (2.2%)	3,126 (90.7%)	3,445 (100.0%)
Total	88 (0.3%)	72 (0.3%)	82 (0.3%)	77 (0.3%)	26,994 (98.8%)	27,313 (100.0%)

Glucose

Variable used: glucose

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	35.00	93.00	118.0	155.00	415.00	129.51	52.12
DOSE	308	16	52.00	91.85	108.0	137.00	371.00	122.76	49.58
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	8	47.00	93.00	111.0	150.00	493.00	135.22	70.07
FIGHT	300	6	45.00	96.00	110.0	143.00	351.00	125.12	47.15
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	314	1.05	86.00	100.0	124.00	493.00	109.75	61.79
INDIE-HFpEF	105	2	50.00	91.50	101.0	130.00	396.00	119.33	53.21
NEAT-HFpEF	110	7	52.00	89.50	99.0	115.50	331.00	117.45	52.50
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	10	40.00	96.00	118.5	156.00	435.00	132.75	56.70
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	1304	2.50	90.91	101.0	114.55	441.82	109.60	37.95
Overall	27313	21787	1.05	90.00	102.0	125.00	493.00	114.76	52.40

On ivabradine

Variable used: hcn4i

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	892 (99.8%)	2 (0.2%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	105 (100.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	997 (3.7%)	2 (0.0%)	26,314 (96.3%)	27,313 (100.0%)

Hematocrit

Variable used: hct

Additional label: Hematocrit, %

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	1	21.60	28.80	33.00	36.60	48.60	32.99	5.34
DOSE	308	6	22.80	30.38	34.35	39.30	54.60	35.05	5.97
ESCAPE	433	12	1.50	34.40	38.20	41.00	56.50	37.78	5.65
EXACT	253	4	26.60	35.50	39.00	41.80	53.10	38.69	4.77
FIGHT	300	7	26.00	34.80	38.80	42.90	55.00	39.00	5.67
GUIDE-IT	894	670	20.10	35.08	40.25	43.20	55.90	39.45	6.13
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	2	28.30	37.20	39.90	42.60	49.60	39.73	4.00
NEAT-HFpEF	110	1	28.80	37.00	39.60	42.90	49.50	39.74	4.11
RELAX	216	1	27.90	35.15	37.90	40.60	53.80	38.03	4.37
ROSE	360	5	25.40	32.00	35.50	39.15	52.00	35.89	4.94
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	84	28.00	40.00	43.00	46.00	55.00	42.93	4.34
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	63	28.00	39.00	42.00	45.00	55.00	42.23	4.72
STICH	2620	45	2.12	36.18	40.03	43.53	748.64	40.81	35.86
TOPCAT	3445	27	21.00	37.00	40.00	43.00	3880.00	41.21	65.88
Overall	27313	12212	1.50	37.30	41.00	44.00	3880.00	41.16	34.91

High density lipoprotein value

Variable used: hdl_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	821	0.42	31	38	48	360	38.8	21.59
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26004	0.42	31	38	48	360	38.8	21.59

Duration of heart failure

Variable used: hf_dur

Additional label: HF dur

Study	<1 year	1-5 years	5+ years	Unknown	Total
ATHENA	120 (33.3%)	103 (28.6%)	130 (36.1%)	7 (1.9%)	360 (100.0%)
CARRESS	36 (19.1%)	57 (30.3%)	89 (47.3%)	6 (3.2%)	188 (100.0%)
DOSE	59 (19.2%)	125 (40.6%)	115 (37.3%)	9 (2.9%)	308 (100.0%)
ESCAPE	42 (9.7%)	38 (8.8%)	27 (6.2%)	326 (75.3%)	433 (100.0%)
EXACT	31 (12.3%)	91 (36.0%)	129 (51.0%)	2 (0.8%)	253 (100.0%)
FIGHT	28 (9.3%)	92 (30.7%)	172 (57.3%)	8 (2.7%)	300 (100.0%)
GUIDE-IT	336 (37.6%)	184 (20.6%)	178 (19.9%)	196 (21.9%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	35 (33.3%)	43 (41.0%)	26 (24.8%)	1 (1.0%)	105 (100.0%)
NEAT-HFpEF	105 (95.5%)	5 (4.5%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	101 (46.8%)	74 (34.3%)	38 (17.6%)	3 (1.4%)	216 (100.0%)
ROSE	56 (15.6%)	128 (35.6%)	163 (45.3%)	13 (3.6%)	360 (100.0%)
SCD-HeFT	838 (33.2%)	1,061 (42.1%)	618 (24.5%)	4 (0.2%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,787 (6.5%)	2,001 (7.3%)	1,685 (6.2%)	21,840 (80.0%)	27,313 (100.0%)

Duration of heart failure value

Variable used: hf_dur_val

Additional label: HF dur, yrs

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	7	0.00	4.70	36.11	83.25	445.08	57.67	69.90
CARRESS	188	6	0.10	19.88	55.82	107.57	589.27	79.77	82.36
DOSE	308	9	0.39	15.92	43.79	94.36	591.28	69.06	79.64
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	2	-1.25	23.75	61.86	121.66	495.31	85.63	81.26
FIGHT	300	8	0.76	39.32	74.61	134.05	427.60	96.51	78.48
GUIDE-IT	894	196	0.00	1.00	12.50	63.50	396.00	44.62	63.94
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	1	0.07	5.26	23.06	57.69	386.43	44.34	62.68
NEAT-HFpEF	110	0	0.04	0.57	1.85	4.19	35.10	3.17	4.66
RELAX	216	3	0.39	3.78	13.86	43.70	296.77	34.23	49.25
ROSE	360	13	0.07	22.67	55.36	99.91	481.22	75.92	73.67
SCD-HeFT	2521	4	0.36	8.11	24.54	59.43	404.70	42.48	48.79
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	21947	-1.25	7.52	29.86	73.21	591.28	52.53	63.77

Hemoglobin

Variable used: hgb

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	1	7.20	9.60	11.00	12.20	16.20	11.00	1.78
DOSE	308	6	7.60	10.12	11.45	13.10	18.20	11.68	1.99
ESCAPE	433	13	3.89	11.38	12.50	13.70	165.00	13.99	13.85
EXACT	253	3	8.70	11.60	12.80	13.90	17.40	12.77	1.68
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	670	6.80	11.47	13.10	14.20	17.90	12.80	2.12
HF-ACTION	2130	514	5.60	12.40	13.50	14.60	18.20	13.47	1.65
INDIE-HFpEF	105	1	8.60	12.07	13.15	14.12	16.40	13.07	1.60
NEAT-HFpEF	110	1	8.60	12.10	13.10	14.10	16.70	13.11	1.53
RELAX	216	1	9.50	11.95	12.90	13.80	18.30	12.93	1.49
ROSE	360	1	8.40	10.30	11.40	12.63	19.98	11.63	1.74
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	45	0.72	12.30	13.61	14.80	254.54	13.88	12.19
TOPCAT	3445	23	6.70	12.20	13.20	14.40	20.30	13.29	1.69
Overall	27313	17530	0.72	12.00	13.20	14.40	254.54	13.31	7.05

Heart rate

Variable used: hr

Additional label: HR, bpm

Study	< 60	100+	60-80	80-100	Unknown	Total
ATHENA	22 (6.1%)	54 (15.0%)	158 (43.9%)	124 (34.4%)	2 (0.6%)	360 (100.0%)
CARRESS	14 (7.4%)	14 (7.4%)	105 (55.9%)	55 (29.3%)	0 (0.0%)	188 (100.0%)
DOSE	20 (6.5%)	30 (9.7%)	171 (55.5%)	86 (27.9%)	1 (0.3%)	308 (100.0%)
ESCAPE	19 (4.4%)	49 (11.3%)	165 (38.1%)	196 (45.3%)	4 (0.9%)	433 (100.0%)
EXACT	22 (8.7%)	6 (2.4%)	150 (59.3%)	75 (29.6%)	0 (0.0%)	253 (100.0%)
FIGHT	21 (7.0%)	14 (4.7%)	163 (54.3%)	101 (33.7%)	1 (0.3%)	300 (100.0%)
GUIDE-IT	79 (8.8%)	58 (6.5%)	435 (48.7%)	315 (35.2%)	7 (0.8%)	894 (100.0%)
HF-ACTION	240 (11.3%)	29 (1.4%)	1,427 (67.0%)	429 (20.1%)	5 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	17 (16.2%)	1 (1.0%)	66 (62.9%)	21 (20.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	13 (11.8%)	2 (1.8%)	71 (64.5%)	24 (21.8%)	0 (0.0%)	110 (100.0%)
RELAX	41 (19.0%)	2 (0.9%)	125 (57.9%)	48 (22.2%)	0 (0.0%)	216 (100.0%)
ROSE	30 (8.3%)	21 (5.8%)	195 (54.2%)	114 (31.7%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	259 (10.3%)	91 (3.6%)	1,322 (52.4%)	840 (33.3%)	9 (0.4%)	2,521 (100.0%)
SOLVD Prevent	301 (7.1%)	75 (1.8%)	2,277 (53.9%)	1,554 (36.8%)	21 (0.5%)	4,228 (100.0%)
SOLVD Registry	277 (4.4%)	596 (9.5%)	2,372 (37.8%)	2,715 (43.3%)	313 (5.0%)	6,273 (100.0%)
SOLVD Treat	95 (3.7%)	131 (5.1%)	1,083 (42.2%)	1,251 (48.7%)	9 (0.4%)	2,569 (100.0%)
STICH	261 (10.0%)	71 (2.7%)	1,509 (57.6%)	755 (28.8%)	24 (0.9%)	2,620 (100.0%)
TOPCAT	501 (14.5%)	16 (0.5%)	2,342 (68.0%)	581 (16.9%)	5 (0.1%)	3,445 (100.0%)
Total	2,232 (8.2%)	1,260 (4.6%)	14,136 (51.8%)	9,284 (34.0%)	401 (1.5%)	27,313 (100.0%)

Heart rate value

Variable used: hr_val

Additional label: HR

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	2	38	70.00	79	92.00	130	81.33	16.66
CARRESS	188	0	40	65.75	75	84.25	148	76.66	15.34
DOSE	308	1	44	69.00	76	85.00	136	78.33	15.78
ESCAPE	433	4	48	70.00	81	92.00	181	82.27	15.67
EXACT	253	0	40	64.00	72	81.00	114	73.46	12.30
FIGHT	300	1	40	68.00	76	86.00	124	76.94	13.33
GUIDE-IT	894	7	41	67.00	76	86.00	149	77.27	14.67
HF-ACTION	2130	5	36	63.00	70	77.00	150	70.89	11.47
INDIE-HFpEF	105	0	1	1.00	1	1.00	1	1.00	0.00
NEAT-HFpEF	110	0	45	63.00	68	75.75	106	71.27	12.33
RELAX	216	0	43	61.00	69	78.00	107	69.70	11.84
ROSE	360	0	46	65.00	74	85.00	119	76.15	14.04
SCD-HeFT	2521	9	39	64.00	73	84.00	140	74.70	13.84
SOLVD Prevent	4228	21	45	65.00	76	82.00	120	74.90	12.38
SOLVD Registry	6273	313	34	70.00	80	90.00	182	81.57	16.81
SOLVD Treat	2569	9	45	72.00	80	88.00	120	79.94	13.22
STICH	2620	24	15	65.00	72	80.00	180	73.90	14.14
TOPCAT	3445	5	38	62.00	68	76.00	130	69.07	10.40
Overall	27313	401	1	65.00	75	84.00	182	75.69	15.24

Hypertension

Variable used: htn

Additional label: HTN

Study	No	Yes	Unknown	Total
ATHENA	59 (16.4%)	301 (83.6%)	0 (0.0%)	360 (100.0%)
CARRESS	29 (15.4%)	159 (84.6%)	0 (0.0%)	188 (100.0%)
DOSE	62 (20.1%)	246 (79.9%)	0 (0.0%)	308 (100.0%)
ESCAPE	230 (53.1%)	203 (46.9%)	0 (0.0%)	433 (100.0%)
EXACT	55 (21.7%)	198 (78.3%)	0 (0.0%)	253 (100.0%)
FIGHT	65 (21.7%)	235 (78.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	188 (21.0%)	706 (79.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	870 (40.8%)	1,260 (59.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	11 (10.0%)	99 (90.0%)	0 (0.0%)	110 (100.0%)
RELAX	33 (15.3%)	183 (84.7%)	0 (0.0%)	216 (100.0%)
ROSE	62 (17.2%)	298 (82.8%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,121 (44.5%)	1,400 (55.5%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	2,661 (62.9%)	1,567 (37.1%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	3,637 (58.0%)	2,636 (42.0%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	1,484 (57.8%)	1,085 (42.2%)	0 (0.0%)	2,569 (100.0%)
STICH	1,014 (38.7%)	1,606 (61.3%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	298 (8.7%)	3,147 (91.3%)	0 (0.0%)	3,445 (100.0%)
Total	11,879 (43.5%)	15,329 (56.1%)	105 (0.4%)	27,313 (100.0%)

On hydralazine

Variable used: hydral

Additional label: Hydralazine

Study	No	Yes	Unknown	Total
ATHENA	289 (80.3%)	71 (19.7%)	0 (0.0%)	360 (100.0%)
CARRESS	153 (81.4%)	35 (18.6%)	0 (0.0%)	188 (100.0%)
DOSE	255 (82.8%)	53 (17.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	396 (91.5%)	37 (8.5%)	0 (0.0%)	433 (100.0%)
EXACT	205 (81.0%)	48 (19.0%)	0 (0.0%)	253 (100.0%)
FIGHT	202 (67.3%)	98 (32.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	709 (79.3%)	185 (20.7%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	97 (92.4%)	8 (7.6%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	106 (96.4%)	4 (3.6%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	292 (81.1%)	68 (18.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,437 (96.7%)	84 (3.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	4,206 (99.5%)	22 (0.5%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	6,134 (97.8%)	139 (2.2%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	2,477 (96.4%)	92 (3.6%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	3,340 (97.0%)	105 (3.0%)	0 (0.0%)	3,445 (100.0%)
Total	21,514 (78.8%)	1,049 (3.8%)	4,750 (17.4%)	27,313 (100.0%)

Implantable cardiac defibrillator

Variable used: icd

Additional label: ICD

Study	No	Yes	Unknown	Total
ATHENA	254 (70.6%)	106 (29.4%)	0 (0.0%)	360 (100.0%)
CARRESS	130 (69.1%)	58 (30.9%)	0 (0.0%)	188 (100.0%)
DOSE	189 (61.4%)	119 (38.6%)	0 (0.0%)	308 (100.0%)
ESCAPE	318 (73.4%)	115 (26.6%)	0 (0.0%)	433 (100.0%)
EXACT	81 (32.0%)	172 (68.0%)	0 (0.0%)	253 (100.0%)
FIGHT	73 (24.3%)	227 (75.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	534 (59.7%)	360 (40.3%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,265 (59.4%)	865 (40.6%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	103 (98.1%)	2 (1.9%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	110 (100.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	215 (99.5%)	1 (0.5%)	0 (0.0%)	216 (100.0%)
ROSE	203 (56.4%)	157 (43.6%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,692 (67.1%)	829 (32.9%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	6,214 (99.1%)	59 (0.9%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,506 (95.6%)	114 (4.4%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,401 (98.7%)	44 (1.3%)	0 (0.0%)	3,445 (100.0%)
Total	17,288 (63.3%)	3,228 (11.8%)	6,797 (24.9%)	27,313 (100.0%)

Carboxy-terminal telopeptide of collagen type I value

Variable used: ictp_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	2.87	12.61	19.34	27.84	156.54	22.53	16.15
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	2	0.30	4.71	6.28	9.86	30.42	7.99	5.14
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26917	0.30	5.79	10.70	19.58	156.54	14.67	13.65

Family income classification

Variable used: income

Additional label: NA

Study	$12000-15999	$20000-24999	$25000-34999	$25000-49999	$35000-49999	$50000-74999	$75000-99999	>$100,000	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	220 (50.8%)	0 (0.0%)	85 (19.6%)	0 (0.0%)	40 (9.2%)	8 (1.8%)	12 (2.8%)	68 (15.7%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	423 (19.9%)	353 (16.6%)	283 (13.3%)	0 (0.0%)	286 (13.4%)	290 (13.6%)	139 (6.5%)	129 (6.1%)	227 (10.7%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	423 (1.5%)	573 (2.1%)	283 (1.0%)	85 (0.3%)	286 (1.0%)	330 (1.2%)	147 (0.5%)	141 (0.5%)	25,045 (91.7%)	27,313 (100.0%)

On insulin

Variable used: insulin

Additional label: Insulin

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	108 (57.4%)	80 (42.6%)	0 (0.0%)	188 (100.0%)
DOSE	213 (69.2%)	95 (30.8%)	0 (0.0%)	308 (100.0%)
ESCAPE	360 (83.1%)	73 (16.9%)	0 (0.0%)	433 (100.0%)
EXACT	188 (74.3%)	65 (25.7%)	0 (0.0%)	253 (100.0%)
FIGHT	300 (100.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	729 (81.5%)	165 (18.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,832 (86.0%)	298 (14.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	90 (81.8%)	20 (18.2%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	227 (63.1%)	133 (36.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,228 (88.4%)	293 (11.6%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	5,777 (92.1%)	496 (7.9%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,186 (83.4%)	434 (16.6%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,018 (87.6%)	427 (12.4%)	0 (0.0%)	3,445 (100.0%)
Total	17,472 (64.0%)	2,579 (9.4%)	7,262 (26.6%)	27,313 (100.0%)

Ischemic cardiomyopathy

Variable used: ischemic_cm

Additional label: Ischemic CM

Study	Ischemic	Nonischemic	Yes	Unknown	Total
ATHENA	226 (62.8%)	134 (37.2%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	84 (44.7%)	104 (55.3%)	0 (0.0%)	0 (0.0%)	188 (100.0%)
DOSE	152 (49.4%)	156 (50.6%)	0 (0.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	213 (49.2%)	218 (50.3%)	0 (0.0%)	2 (0.5%)	433 (100.0%)
EXACT	107 (42.3%)	146 (57.7%)	0 (0.0%)	0 (0.0%)	253 (100.0%)
FIGHT	246 (82.0%)	54 (18.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	315 (35.2%)	576 (64.4%)	0 (0.0%)	3 (0.3%)	894 (100.0%)
HF-ACTION	1,096 (51.5%)	1,034 (48.5%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	73 (69.5%)	32 (30.5%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	84 (38.9%)	132 (61.1%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	159 (44.2%)	201 (55.8%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,310 (52.0%)	1,211 (48.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	3,518 (83.2%)	702 (16.6%)	0 (0.0%)	8 (0.2%)	4,228 (100.0%)
SOLVD Registry	4,312 (68.7%)	1,960 (31.2%)	0 (0.0%)	1 (0.0%)	6,273 (100.0%)
SOLVD Treat	1,832 (71.3%)	731 (28.5%)	0 (0.0%)	6 (0.2%)	2,569 (100.0%)
STICH	2,608 (99.5%)	0 (0.0%)	0 (0.0%)	12 (0.5%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	2,023 (58.7%)	1,422 (41.3%)	3,445 (100.0%)
Total	16,335 (59.8%)	7,391 (27.1%)	2,023 (7.4%)	1,564 (5.7%)	27,313 (100.0%)

Septal wall thickness

Variable used: ivsd

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	83 (19.2%)	17 (3.9%)	179 (41.3%)	4 (0.9%)	150 (34.6%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	68 (22.7%)	13 (4.3%)	184 (61.3%)	6 (2.0%)	29 (9.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	46 (41.8%)	17 (15.5%)	40 (36.4%)	5 (4.5%)	2 (1.8%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	230 (3.7%)	74 (1.2%)	456 (7.3%)	20 (0.3%)	5,493 (87.6%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	32 (1.2%)	3 (0.1%)	74 (2.8%)	0 (0.0%)	2,511 (95.8%)	2,620 (100.0%)
TOPCAT	383 (11.1%)	92 (2.7%)	144 (4.2%)	15 (0.4%)	2,811 (81.6%)	3,445 (100.0%)
Total	842 (3.1%)	216 (0.8%)	1,077 (3.9%)	50 (0.2%)	25,128 (92.0%)	27,313 (100.0%)

Elevated jugular venous pressure

Variable used: jvp

Additional label: JVP

Study	No	Yes	Unknown	Total
ATHENA	30 (8.3%)	318 (88.3%)	12 (3.3%)	360 (100.0%)
CARRESS	6 (3.2%)	174 (92.6%)	8 (4.3%)	188 (100.0%)
DOSE	25 (8.1%)	267 (86.7%)	16 (5.2%)	308 (100.0%)
ESCAPE	35 (8.1%)	386 (89.1%)	12 (2.8%)	433 (100.0%)
EXACT	175 (69.2%)	72 (28.5%)	6 (2.4%)	253 (100.0%)
FIGHT	152 (50.7%)	138 (46.0%)	10 (3.3%)	300 (100.0%)
GUIDE-IT	594 (66.4%)	243 (27.2%)	57 (6.4%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	66 (62.9%)	37 (35.2%)	2 (1.9%)	105 (100.0%)
NEAT-HFpEF	72 (65.5%)	37 (33.6%)	1 (0.9%)	110 (100.0%)
RELAX	114 (52.8%)	95 (44.0%)	7 (3.2%)	216 (100.0%)
ROSE	16 (4.4%)	327 (90.8%)	17 (4.7%)	360 (100.0%)
SCD-HeFT	2,129 (84.5%)	331 (13.1%)	61 (2.4%)	2,521 (100.0%)
SOLVD Prevent	4,143 (98.0%)	70 (1.7%)	15 (0.4%)	4,228 (100.0%)
SOLVD Registry	4,808 (76.6%)	1,238 (19.7%)	227 (3.6%)	6,273 (100.0%)
SOLVD Treat	2,270 (88.4%)	291 (11.3%)	8 (0.3%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	1,436 (41.7%)	308 (8.9%)	1,701 (49.4%)	3,445 (100.0%)
Total	16,071 (58.8%)	4,332 (15.9%)	6,910 (25.3%)	27,313 (100.0%)

Potassium

Variable used: k

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	2.4	3.6	3.90	4.3	5.0	3.92	0.45
CARRESS	188	1	2.7	3.8	4.10	4.5	6.9	4.17	0.58
DOSE	308	0	2.3	3.5	3.95	4.3	6.5	3.96	0.59
ESCAPE	433	2	2.6	3.8	4.10	4.5	8.0	4.18	0.64
EXACT	253	1	2.9	3.8	4.20	4.6	5.6	4.23	0.52
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	36	2.7	4.0	4.30	4.7	6.9	4.38	0.57
HF-ACTION	2130	228	1.3	4.1	4.40	4.8	5500.0	379.46	1226.24
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	1	3.2	4.0	4.20	4.7	5.8	4.33	0.52
RELAX	216	22	3.0	4.0	4.30	4.7	5.5	4.32	0.51
ROSE	360	0	2.9	3.7	4.00	4.3	5.8	4.05	0.53
SCD-HeFT	2521	16	2.9	4.1	4.40	4.7	6.3	4.40	0.47
SOLVD Prevent	4228	68	3.1	4.1	4.30	4.6	5.9	4.35	0.42
SOLVD Registry	6273	560	0.1	4.0	4.30	4.6	8.4	4.27	0.51
SOLVD Treat	2569	44	3.1	4.0	4.30	4.6	5.9	4.27	0.46
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	4	2.4	4.0	4.30	4.6	6.0	4.25	0.45
Overall	27313	4008	0.1	4.0	4.30	4.6	5500.0	34.90	364.98

KCCQ Clinical summary

Variable used: kccq_clinical_sum

Additional label: KCCQ Clinical summary

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	0.00	42.71	64.58	79.17	100.00	61.51	23.83
FIGHT	300	4	0.00	30.60	45.05	65.23	97.92	47.58	22.68
GUIDE-IT	894	10	0.00	44.79	64.58	81.77	100.00	62.28	23.78
HF-ACTION	2130	1	9.38	58.33	73.96	86.67	100.00	71.36	19.42
INDIE-HFpEF	105	0	10.42	46.35	57.81	72.92	95.83	58.18	19.27
NEAT-HFpEF	110	0	6.25	41.15	58.85	72.40	100.00	57.63	22.57
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	507	0.00	49.48	68.75	85.42	100.00	65.98	22.81
TOPCAT	3445	45	0.00	42.40	56.77	71.88	100.00	57.06	20.22
Overall	27313	18023	0.00	46.80	63.54	80.21	100.00	62.70	22.12

KCCQ Overall summary

Variable used: kccq_overall_sum

Additional label: KCCQ Overall Summary

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	2.08	39.06	60.42	74.48	100.00	57.48	23.98
FIGHT	300	4	2.08	28.91	41.93	61.22	94.79	44.27	20.91
GUIDE-IT	894	10	0.00	39.84	58.98	75.00	100.00	57.04	23.07
HF-ACTION	2130	1	8.33	51.04	67.97	83.33	100.00	66.32	20.51
INDIE-HFpEF	105	0	13.54	43.75	53.91	70.31	95.31	55.85	19.15
NEAT-HFpEF	110	0	3.12	38.02	53.91	76.37	97.92	55.98	24.21
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	507	0.00	40.36	57.81	75.00	100.00	57.34	22.90
TOPCAT	3445	45	1.04	39.30	53.65	69.79	100.00	54.84	20.46
Overall	27313	18023	0.00	41.67	58.33	75.52	100.00	58.01	22.04

KCCQ Physical limitation

Variable used: kccq_phys_lim

Additional label: Physical limit

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	0.00	37.50	62.50	79.17	100	57.99	26.19
FIGHT	300	10	0.00	29.17	50.00	66.67	100	49.48	26.35
GUIDE-IT	894	25	0.00	41.67	66.67	87.50	100	62.46	26.94
HF-ACTION	2130	17	0.00	54.17	70.83	87.50	100	69.44	21.85
INDIE-HFpEF	105	0	0.00	45.83	58.33	75.00	100	59.03	20.84
NEAT-HFpEF	110	0	4.17	37.50	58.33	75.00	100	56.25	24.72
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	546	0.00	43.75	66.67	83.33	100	62.30	25.77
TOPCAT	3445	92	0.00	40.00	54.17	75.00	100	56.11	22.40
Overall	27313	18146	0.00	41.67	62.50	80.00	100	61.06	24.41

KCCQ Quality of life

Variable used: kccq_qol

Additional label: KCCQ QOL

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	1	0.00	33.33	54.17	75.00	100	53.37	26.59
FIGHT	300	7	0.00	25.00	41.67	58.33	100	41.58	23.90
GUIDE-IT	894	25	0.00	41.67	66.67	87.50	100	62.46	26.94
HF-ACTION	2130	11	0.00	41.67	58.33	83.33	100	59.91	24.52
INDIE-HFpEF	105	0	8.33	33.33	50.00	66.67	100	50.48	22.25
NEAT-HFpEF	110	2	0.00	33.33	50.00	75.00	100	52.78	28.32
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	538	0.00	25.00	41.67	66.67	100	44.56	25.48
TOPCAT	3445	52	0.00	33.33	50.00	66.67	100	49.91	23.59
Overall	27313	18092	0.00	33.33	50.00	75.00	100	52.05	25.54

KCCQ Self efficacy

Variable used: kccq_self_eff

Additional label: Self efficacy

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	12.5	75.0	87.50	100.0	100	83.45	20.68
FIGHT	300	5	0.0	75.0	87.50	100.0	100	82.71	21.65
GUIDE-IT	894	15	0.0	75.0	87.50	100.0	100	82.74	20.14
HF-ACTION	2130	5	0.0	75.0	87.50	100.0	100	81.25	20.21
INDIE-HFpEF	105	0	12.5	62.5	87.50	100.0	100	76.67	25.18
NEAT-HFpEF	110	2	0.0	62.5	81.25	100.0	100	77.78	22.69
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	47	0.0	50.0	75.00	87.5	100	68.12	23.73
Overall	27313	20150	0.0	62.5	75.00	100.0	100	75.22	23.14

KCCQ Symptom burden

Variable used: kccq_sym_burd

Additional label: Symptom burden

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	0.00	50.00	75.00	83.33	100	67.36	24.75
FIGHT	300	4	0.00	25.00	50.00	66.67	100	49.28	26.80
GUIDE-IT	894	10	0.00	50.00	66.67	83.33	100	63.90	27.36
HF-ACTION	2130	1	8.33	58.33	75.00	91.67	100	74.75	20.69
INDIE-HFpEF	105	0	0.00	41.67	58.33	75.00	100	58.97	21.33
NEAT-HFpEF	110	0	0.00	41.67	58.33	75.00	100	59.55	23.86
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	511	0.00	50.00	75.00	91.67	100	70.42	23.99
TOPCAT	3445	45	0.00	41.67	58.33	75.00	100	59.25	22.97
Overall	27313	18027	0.00	50.00	66.67	83.33	100	65.68	24.36

KCCQ Symptom frequency

Variable used: kccq_sym_freq

Additional label: Symptom frequency

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	0.00	41.67	66.67	85.42	100	62.70	27.25
FIGHT	300	4	0.00	20.83	37.50	60.42	100	42.36	26.27
GUIDE-IT	894	10	0.00	39.58	62.50	83.33	100	60.23	27.75
HF-ACTION	2130	2	0.00	58.33	75.00	91.67	100	71.66	22.68
INDIE-HFpEF	105	0	4.17	39.58	58.33	77.08	100	55.69	24.95
NEAT-HFpEF	110	2	0.00	41.67	58.33	75.00	100	58.18	25.11
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	512	0.00	52.08	72.92	91.67	100	68.72	25.62
TOPCAT	3445	45	0.00	39.58	58.33	75.00	100	56.64	23.75
Overall	27313	18031	0.00	43.75	64.58	83.33	100	62.88	25.65

KCCQ Symptom stability

Variable used: kccq_sym_stab

Additional label: Symptom stability

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	0	50	50	75	100	55.53	24.07
FIGHT	300	4	0	25	75	100	100	61.06	36.56
GUIDE-IT	894	14	0	50	75	100	100	68.92	29.79
HF-ACTION	2130	13	0	50	50	50	100	54.29	17.04
INDIE-HFpEF	105	0	0	50	50	50	100	50.95	16.96
NEAT-HFpEF	110	0	0	50	50	50	100	47.50	17.25
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	514	0	50	50	50	100	51.64	24.35
TOPCAT	3445	46	0	50	50	75	100	52.96	23.67
Overall	27313	18047	0	50	50	75	100	54.72	24.09

KCCQ Total symptom

Variable used: kccq_tot_sym

Additional label: KCCQ Total symptoms

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	0	0.00	46.88	67.71	87.50	100.00	65.03	25.27
FIGHT	300	4	0.00	26.04	44.79	64.84	100.00	45.82	25.35
GUIDE-IT	894	10	0.00	43.75	65.62	83.33	100.00	62.06	26.35
HF-ACTION	2130	1	4.17	59.38	77.08	89.58	100.00	73.19	20.73
INDIE-HFpEF	105	0	10.42	45.83	54.17	73.96	97.92	57.33	21.78
NEAT-HFpEF	110	0	0.00	43.75	55.73	75.00	100.00	59.02	23.50
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	510	0.00	53.12	72.40	89.58	100.00	69.56	23.93
TOPCAT	3445	45	0.00	41.67	57.29	75.00	100.00	57.94	22.19
Overall	27313	18026	0.00	46.88	66.67	83.33	100.00	64.28	24.00

LA end systolic area

Variable used: laa

Additional label: LAA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	113 (26.1%)	116 (26.8%)	18 (4.2%)	34 (7.9%)	152 (35.1%)	433 (100.0%)
EXACT	60 (23.7%)	25 (9.9%)	10 (4.0%)	5 (2.0%)	153 (60.5%)	253 (100.0%)
FIGHT	135 (45.0%)	88 (29.3%)	22 (7.3%)	18 (6.0%)	37 (12.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	46 (41.8%)	15 (13.6%)	32 (29.1%)	2 (1.8%)	15 (13.6%)	110 (100.0%)
RELAX	102 (47.2%)	47 (21.8%)	24 (11.1%)	5 (2.3%)	38 (17.6%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	220 (6.4%)	13 (0.4%)	354 (10.3%)	1 (0.0%)	2,857 (82.9%)	3,445 (100.0%)
Total	676 (2.5%)	304 (1.1%)	460 (1.7%)	65 (0.2%)	25,808 (94.5%)	27,313 (100.0%)

LA end systolic area value

Variable used: laa_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	152	10.80	25.50	30.60	35.40	59.10	30.84	7.69
EXACT	253	153	12.10	24.35	27.20	31.95	55.40	27.94	7.32
FIGHT	300	37	2.40	25.05	28.40	33.50	56.10	29.07	7.66
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	15	10.50	18.65	21.50	25.90	44.00	22.97	6.87
RELAX	216	38	13.10	21.70	25.25	30.85	52.60	26.69	6.73
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	2857	7.92	15.64	18.62	22.99	53.78	19.36	5.20
Overall	27313	25808	2.40	18.73	24.22	29.90	59.10	24.87	8.15

LA volume index

Variable used: lav_ix

Additional label: LAV index

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	18 (7.1%)	27 (10.7%)	25 (9.9%)	96 (37.9%)	87 (34.4%)	253 (100.0%)
FIGHT	30 (10.0%)	38 (12.7%)	19 (6.3%)	131 (43.7%)	82 (27.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	17 (15.5%)	16 (14.5%)	35 (31.8%)	23 (20.9%)	19 (17.3%)	110 (100.0%)
RELAX	25 (11.6%)	29 (13.4%)	29 (13.4%)	66 (30.6%)	67 (31.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	258 (9.8%)	218 (8.3%)	362 (13.8%)	354 (13.5%)	1,428 (54.5%)	2,620 (100.0%)
TOPCAT	90 (2.6%)	53 (1.5%)	432 (12.5%)	34 (1.0%)	2,836 (82.3%)	3,445 (100.0%)
Total	438 (1.6%)	381 (1.4%)	902 (3.3%)	704 (2.6%)	24,888 (91.1%)	27,313 (100.0%)

LA volume index value

Variable used: lav_ix_val

Additional label: LAV index, ml/m2

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	87	20.38	40.91	51.15	62.42	172.72	56.00	25.84
FIGHT	300	82	0.36	42.86	52.27	65.10	160.79	55.45	20.82
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	19	17.73	30.06	38.51	48.27	103.09	41.17	15.78
RELAX	216	67	13.40	35.66	44.54	60.23	182.27	50.27	21.32
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26689	0.36	38.09	48.39	61.51	182.27	52.28	22.32

LBBB

Variable used: lbbb

Additional label: LBBB

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	354 (81.8%)	79 (18.2%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	1,792 (84.1%)	338 (15.9%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,146 (7.9%)	417 (1.5%)	24,750 (90.6%)	27,313 (100.0%)

Low density lipoprotein value

Variable used: ldl_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	850	0.48	63	86	112	1160	88.01	57.69
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26033	0.48	63	86	112	1160	88.01	57.69

Hyperlipidemia

Variable used: lipid

Additional label: HLD

Study	No	Yes	Unknown	Total
ATHENA	158 (43.9%)	202 (56.1%)	0 (0.0%)	360 (100.0%)
CARRESS	44 (23.4%)	144 (76.6%)	0 (0.0%)	188 (100.0%)
DOSE	95 (30.8%)	213 (69.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	433 (100.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)
EXACT	58 (22.9%)	195 (77.1%)	0 (0.0%)	253 (100.0%)
FIGHT	91 (30.3%)	209 (69.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	370 (41.4%)	524 (58.6%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	29 (27.6%)	76 (72.4%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	42 (38.2%)	68 (61.8%)	0 (0.0%)	110 (100.0%)
RELAX	56 (25.9%)	160 (74.1%)	0 (0.0%)	216 (100.0%)
ROSE	81 (22.5%)	279 (77.5%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,192 (47.3%)	1,329 (52.7%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	874 (33.4%)	1,746 (66.6%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	1,372 (39.8%)	2,073 (60.2%)	0 (0.0%)	3,445 (100.0%)
Total	7,025 (25.7%)	7,218 (26.4%)	13,070 (47.9%)	27,313 (100.0%)

On lipid lowering therapy

Variable used: lipid_lower_tx

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	138 (38.3%)	222 (61.7%)	0 (0.0%)	360 (100.0%)
CARRESS	40 (21.3%)	148 (78.7%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	269 (62.1%)	164 (37.9%)	0 (0.0%)	433 (100.0%)
EXACT	66 (26.1%)	187 (73.9%)	0 (0.0%)	253 (100.0%)
FIGHT	80 (26.7%)	220 (73.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	347 (38.8%)	547 (61.2%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	37 (35.2%)	68 (64.8%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	36 (32.7%)	74 (67.3%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	1,556 (61.7%)	965 (38.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	581 (22.2%)	2,039 (77.8%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	5,496 (20.1%)	4,634 (17.0%)	17,183 (62.9%)	27,313 (100.0%)

On loop diuretic

Variable used: loop

Additional label: Loop diuretic

Study	No	Yes	Unknown	Total
ATHENA	88 (24.4%)	272 (75.6%)	0 (0.0%)	360 (100.0%)
CARRESS	12 (6.4%)	176 (93.6%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	308 (100.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	16 (3.7%)	417 (96.3%)	0 (0.0%)	433 (100.0%)
EXACT	5 (2.0%)	248 (98.0%)	0 (0.0%)	253 (100.0%)
FIGHT	3 (1.0%)	297 (99.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	45 (5.0%)	849 (95.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	466 (21.9%)	1,664 (78.1%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	24 (22.9%)	81 (77.1%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	38 (34.5%)	72 (65.5%)	0 (0.0%)	110 (100.0%)
RELAX	50 (23.1%)	166 (76.9%)	0 (0.0%)	216 (100.0%)
ROSE	20 (5.6%)	340 (94.4%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	457 (18.1%)	2,064 (81.9%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	3,949 (93.4%)	279 (6.6%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	636 (24.8%)	1,933 (75.2%)	0 (0.0%)	2,569 (100.0%)
STICH	943 (36.0%)	1,677 (64.0%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	1,644 (47.7%)	1,801 (52.3%)	0 (0.0%)	3,445 (100.0%)
Total	8,396 (30.7%)	12,644 (46.3%)	6,273 (23.0%)	27,313 (100.0%)

LVEDD index

Variable used: lvedd_ix

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	42 (16.6%)	22 (8.7%)	108 (42.7%)	39 (15.4%)	42 (16.6%)	253 (100.0%)
FIGHT	55 (18.3%)	33 (11.0%)	136 (45.3%)	48 (16.0%)	28 (9.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	286 (13.4%)	186 (8.7%)	725 (34.0%)	303 (14.2%)	630 (29.6%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	106 (96.4%)	0 (0.0%)	4 (3.6%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	164 (75.9%)	0 (0.0%)	52 (24.1%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	102 (1.6%)	79 (1.3%)	496 (7.9%)	119 (1.9%)	5,477 (87.3%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	325 (12.4%)	222 (8.5%)	582 (22.2%)	303 (11.6%)	1,188 (45.3%)	2,620 (100.0%)
TOPCAT	4 (0.1%)	2 (0.1%)	625 (18.1%)	2 (0.1%)	2,812 (81.6%)	3,445 (100.0%)
Total	814 (3.0%)	544 (2.0%)	2,942 (10.8%)	814 (3.0%)	22,199 (81.3%)	27,313 (100.0%)

LVEDD index value

Variable used: lvedd_ix_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	42	0.42	2.87	3.19	3.58	5.08	3.24	0.58
FIGHT	300	28	0.39	2.89	3.22	3.56	5.07	3.25	0.58
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	630	1.26	2.88	3.25	3.64	6.71	3.27	0.64
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	4	1.65	2.10	2.29	2.55	3.17	2.31	0.32
RELAX	216	52	1.59	2.07	2.26	2.46	3.17	2.29	0.30
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5477	1.82	2.71	3.05	3.50	5.31	3.12	0.60
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1188	1.86	3.01	3.32	3.66	5.78	3.35	0.49
TOPCAT	3445	2812	1.59	2.22	2.42	2.65	4.26	2.45	0.34
Overall	27313	22199	0.39	2.65	3.11	3.53	6.71	3.11	0.64

LV diastolic volume

Variable used: lvedv

Additional label: LV EDV, mL

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	13 (3.0%)	16 (3.7%)	12 (2.8%)	178 (41.1%)	214 (49.4%)	433 (100.0%)
EXACT	10 (4.0%)	14 (5.5%)	5 (2.0%)	133 (52.6%)	91 (36.0%)	253 (100.0%)
FIGHT	6 (2.0%)	10 (3.3%)	4 (1.3%)	213 (71.0%)	67 (22.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	7 (3.2%)	2 (0.9%)	42 (19.4%)	5 (2.3%)	160 (74.1%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	156 (2.5%)	147 (2.3%)	105 (1.7%)	391 (6.2%)	5,474 (87.3%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	47 (1.8%)	54 (2.1%)	70 (2.7%)	254 (9.7%)	2,195 (83.8%)	2,620 (100.0%)
TOPCAT	51 (1.5%)	22 (0.6%)	532 (15.4%)	30 (0.9%)	2,810 (81.6%)	3,445 (100.0%)
Total	290 (1.1%)	265 (1.0%)	770 (2.8%)	1,204 (4.4%)	24,784 (90.7%)	27,313 (100.0%)

LV diastolic volume echo

Variable used: lvedv_echo

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	10 (4.0%)	14 (5.5%)	5 (2.0%)	133 (52.6%)	91 (36.0%)	253 (100.0%)
FIGHT	6 (2.0%)	10 (3.3%)	4 (1.3%)	213 (71.0%)	67 (22.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	15 (6.9%)	3 (1.4%)	73 (33.8%)	15 (6.9%)	110 (50.9%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	142 (5.4%)	207 (7.9%)	153 (5.8%)	962 (36.7%)	1,156 (44.1%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	173 (0.6%)	234 (0.9%)	235 (0.9%)	1,323 (4.8%)	25,348 (92.8%)	27,313 (100.0%)

LV diastolic volume mri

Variable used: lvedv_mri

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	18 (8.3%)	12 (5.6%)	66 (30.6%)	21 (9.7%)	99 (45.8%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	47 (1.8%)	54 (2.1%)	70 (2.7%)	254 (9.7%)	2,195 (83.8%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	65 (0.2%)	66 (0.2%)	136 (0.5%)	275 (1.0%)	26,771 (98.0%)	27,313 (100.0%)

LV diastolic volume rn

Variable used: lvedv_rn

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	61 (2.3%)	90 (3.4%)	61 (2.3%)	578 (22.1%)	1,830 (69.8%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	61 (0.2%)	90 (0.3%)	61 (0.2%)	578 (2.1%)	26,523 (97.1%)	27,313 (100.0%)

LV diastolic volume value

Variable used: lvedv_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	214	86.33	198.50	249.00	319.00	946.33	269.63	114.15
EXACT	253	91	70.00	201.00	262.50	349.50	575.00	278.35	97.29
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	160	45.00	87.75	99.00	126.00	245.00	110.11	38.22
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5474	76.00	153.00	181.00	218.00	492.00	189.23	51.58
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	865	66.00	170.00	215.00	269.00	746.00	226.44	79.95
TOPCAT	3445	2810	27.42	74.52	93.19	117.52	232.85	98.74	33.33
Overall	27313	23687	27.42	138.00	188.00	245.00	946.33	199.01	89.17

LVESD index

Variable used: lvesd_ix

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	22 (7.3%)	32 (10.7%)	27 (9.0%)	179 (59.7%)	40 (13.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	96 (1.5%)	79 (1.3%)	228 (3.6%)	375 (6.0%)	5,495 (87.6%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	118 (4.5%)	159 (6.1%)	97 (3.7%)	966 (36.9%)	1,280 (48.9%)	2,620 (100.0%)
TOPCAT	36 (1.0%)	10 (0.3%)	578 (16.8%)	5 (0.1%)	2,816 (81.7%)	3,445 (100.0%)
Total	272 (1.0%)	280 (1.0%)	930 (3.4%)	1,525 (5.6%)	24,306 (89.0%)	27,313 (100.0%)

LVESD index value

Variable used: lvesd_ix_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	39	0.34	2.43	2.78	3.21	4.82	2.82	0.62
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5484	0.98	2.00	2.47	2.98	4.95	2.53	0.70
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1268	1.44	2.47	2.82	3.19	4.98	2.84	0.53
TOPCAT	3445	2812	1.03	1.53	1.67	1.86	3.43	1.71	0.28
Overall	27313	24278	0.34	1.94	2.52	3.01	4.98	2.52	0.70

LVH type

Variable used: lvh_type

Additional label: LV hypertrophy

Study	Concentric hypertrophy	Concentric remodeling	Eccentric hypertrophy	Normal geometry	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	19 (4.4%)	2 (0.5%)	194 (44.8%)	59 (13.6%)	159 (36.7%)	433 (100.0%)
EXACT	7 (2.8%)	2 (0.8%)	120 (47.4%)	78 (30.8%)	46 (18.2%)	253 (100.0%)
FIGHT	16 (5.3%)	4 (1.3%)	167 (55.7%)	75 (25.0%)	38 (12.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	11 (10.0%)	23 (20.9%)	8 (7.3%)	64 (58.2%)	4 (3.6%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	104 (1.7%)	44 (0.7%)	374 (6.0%)	246 (3.9%)	5,505 (87.8%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	89 (3.4%)	20 (0.8%)	752 (28.7%)	477 (18.2%)	1,282 (48.9%)	2,620 (100.0%)
TOPCAT	257 (7.5%)	229 (6.6%)	57 (1.7%)	89 (2.6%)	2,813 (81.7%)	3,445 (100.0%)
Total	503 (1.8%)	324 (1.2%)	1,672 (6.1%)	1,088 (4.0%)	23,726 (86.9%)	27,313 (100.0%)

LV diastolic diameter

Variable used: lvidd

Additional label: NA

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	39 (9.0%)	46 (10.6%)	57 (13.2%)	139 (32.1%)	152 (35.1%)	433 (100.0%)
EXACT	28 (11.1%)	48 (19.0%)	38 (15.0%)	99 (39.1%)	40 (15.8%)	253 (100.0%)
FIGHT	43 (14.3%)	53 (17.7%)	37 (12.3%)	140 (46.7%)	27 (9.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	199 (9.3%)	266 (12.5%)	259 (12.2%)	772 (36.2%)	634 (29.8%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	4 (3.6%)	1 (0.9%)	98 (89.1%)	1 (0.9%)	6 (5.5%)	110 (100.0%)
RELAX	5 (2.3%)	3 (1.4%)	150 (69.4%)	0 (0.0%)	58 (26.9%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	153 (2.4%)	105 (1.7%)	377 (6.0%)	164 (2.6%)	5,474 (87.3%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	39 (1.1%)	11 (0.3%)	569 (16.5%)	4 (0.1%)	2,822 (81.9%)	3,445 (100.0%)
Total	510 (1.9%)	533 (2.0%)	1,585 (5.8%)	1,319 (4.8%)	23,366 (85.5%)	27,313 (100.0%)

LV diastolic diameter value

Variable used: lvidd_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	151	3.89	5.88	6.54	7.29	10.15	6.63	1.09
EXACT	253	39	0.90	6.10	6.60	7.30	9.50	6.68	1.02
FIGHT	300	27	0.70	6.10	6.70	7.40	9.80	6.73	1.02
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	626	3.15	5.87	6.59	7.39	11.96	6.64	1.21
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	4	3.70	4.40	4.80	5.10	7.00	4.76	0.56
RELAX	216	52	3.30	4.20	4.60	5.12	6.80	4.68	0.64
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5467	3.90	5.20	5.80	6.50	9.10	5.90	0.99
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	2811	3.15	4.37	4.79	5.15	6.86	4.78	0.58
Overall	27313	23330	0.70	5.10	6.03	6.90	11.96	6.07	1.28

LV mass

Variable used: lvmass

Additional label: LV mass

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	34 (7.9%)	40 (9.2%)	55 (12.7%)	152 (35.1%)	152 (35.1%)	433 (100.0%)
EXACT	29 (11.5%)	22 (8.7%)	70 (27.7%)	88 (34.8%)	44 (17.4%)	253 (100.0%)
FIGHT	34 (11.3%)	34 (11.3%)	67 (22.3%)	128 (42.7%)	37 (12.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	147 (6.9%)	144 (6.8%)	327 (15.4%)	888 (41.7%)	624 (29.3%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	15 (13.6%)	12 (10.9%)	68 (61.8%)	11 (10.0%)	4 (3.6%)	110 (100.0%)
RELAX	7 (3.2%)	5 (2.3%)	101 (46.8%)	4 (1.9%)	99 (45.8%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	120 (1.9%)	103 (1.6%)	301 (4.8%)	254 (4.0%)	5,495 (87.6%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	249 (9.5%)	199 (7.6%)	520 (19.8%)	370 (14.1%)	1,282 (48.9%)	2,620 (100.0%)
TOPCAT	118 (3.4%)	115 (3.3%)	251 (7.3%)	149 (4.3%)	2,812 (81.6%)	3,445 (100.0%)
Total	753 (2.8%)	674 (2.5%)	1,760 (6.4%)	2,044 (7.5%)	22,082 (80.8%)	27,313 (100.0%)

LV mass index

Variable used: lvmass_ix

Additional label: LV mass index, g/m2

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	31 (7.2%)	47 (10.9%)	64 (14.8%)	132 (30.5%)	159 (36.7%)	433 (100.0%)
EXACT	36 (14.2%)	25 (9.9%)	83 (32.8%)	63 (24.9%)	46 (18.2%)	253 (100.0%)
FIGHT	39 (13.0%)	42 (14.0%)	80 (26.7%)	101 (33.7%)	38 (12.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	153 (7.2%)	149 (7.0%)	398 (18.7%)	802 (37.7%)	628 (29.5%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	13 (11.8%)	4 (3.6%)	88 (80.0%)	1 (0.9%)	4 (3.6%)	110 (100.0%)
RELAX	4 (1.9%)	2 (0.9%)	108 (50.0%)	3 (1.4%)	99 (45.8%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	112 (1.8%)	111 (1.8%)	298 (4.8%)	247 (3.9%)	5,505 (87.8%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	235 (9.0%)	201 (7.7%)	515 (19.7%)	387 (14.8%)	1,282 (48.9%)	2,620 (100.0%)
TOPCAT	103 (3.0%)	97 (2.8%)	328 (9.5%)	104 (3.0%)	2,813 (81.7%)	3,445 (100.0%)
Total	726 (2.7%)	678 (2.5%)	1,962 (7.2%)	1,840 (6.7%)	22,107 (80.9%)	27,313 (100.0%)

LV mass index value mri

Variable used: lvmass_ix_mri

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	99	39.8	54.90	64.40	80.00	167.9	70.79	24.26
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2334	0.0	64.37	84.29	99.14	Inf	Inf	NaN
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26910	0.0	58.78	78.03	96.88	Inf	Inf	NaN

LV mass index value

Variable used: lvmass_ix_val

Additional label: LV mass index

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	159	49.86	115.55	143.32	176.71	19404.65	221.75	1164.45
EXACT	253	46	41.65	99.75	120.47	151.76	1251.60	132.85	89.35
FIGHT	300	38	40.77	103.42	129.94	154.44	3252.10	145.17	199.35
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	628	15.42	106.02	145.49	190.06	880.75	155.55	79.70
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	4	39.80	67.77	78.72	98.36	156.89	83.23	22.61
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5505	38.32	97.89	121.77	151.08	422.94	129.15	44.20
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1282	33.43	101.39	123.78	149.72	340.99	127.77	37.36
TOPCAT	3445	2813	41.12	87.41	105.63	125.53	221.97	109.14	30.26
Overall	27313	22224	15.42	98.60	124.83	157.72	19404.65	139.10	280.09

LV mass value mri

Variable used: lvmass_mri

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	99	68.96	103.05	137.23	172	330.67	147.48	58.02
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2324	0.00	120.50	159.00	195	352.00	157.81	64.47
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26900	0.00	112.10	150.96	190	352.00	154.89	62.81

LV mass value

Variable used: lvmass_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	152	94.16	220.11	275.16	348.73	37733.54	432.72	2236.30
EXACT	253	44	78.86	202.77	249.31	325.53	2697.16	277.85	193.14
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	624	31.80	212.98	294.58	388.14	1764.84	319.93	170.80
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	4	77.48	132.22	157.44	200.48	338.76	174.93	58.59
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5495	82.26	186.41	230.97	288.62	693.77	245.04	84.53
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1282	62.67	191.59	234.72	284.66	551.90	242.08	73.15
TOPCAT	3445	2812	74.67	167.18	203.73	253.77	477.05	215.64	67.30
Overall	27313	22462	31.80	190.44	243.22	315.88	37733.54	274.39	553.03

LV posterior wall thickness

Variable used: lvpwd

Additional label: LVPWd, cm

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	56 (12.9%)	5 (1.2%)	217 (50.1%)	4 (0.9%)	151 (34.9%)	433 (100.0%)
EXACT	48 (19.0%)	5 (2.0%)	159 (62.8%)	1 (0.4%)	40 (15.8%)	253 (100.0%)
FIGHT	65 (21.7%)	9 (3.0%)	190 (63.3%)	2 (0.7%)	34 (11.3%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	25 (22.7%)	3 (2.7%)	78 (70.9%)	1 (0.9%)	3 (2.7%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	270 (4.3%)	30 (0.5%)	481 (7.7%)	2 (0.0%)	5,490 (87.5%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	34 (1.3%)	1 (0.0%)	81 (3.1%)	0 (0.0%)	2,504 (95.6%)	2,620 (100.0%)
TOPCAT	368 (10.7%)	62 (1.8%)	191 (5.5%)	12 (0.3%)	2,812 (81.6%)	3,445 (100.0%)
Total	866 (3.2%)	115 (0.4%)	1,397 (5.1%)	22 (0.1%)	24,913 (91.2%)	27,313 (100.0%)

LV posterior wall thickness value

Variable used: lvpwd_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	151	0.50	0.83	0.95	1.07	29.30	1.07	1.71
EXACT	253	40	0.30	0.70	0.90	1.00	6.50	0.91	0.44
FIGHT	300	34	0.30	0.80	0.90	1.08	7.00	0.94	0.48
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	3	0.59	0.76	0.86	1.00	1.90	0.91	0.22
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2504	0.30	0.80	0.90	1.10	1.30	0.92	0.20
TOPCAT	3445	2812	0.60	1.02	1.13	1.26	2.26	1.15	0.19
Overall	27313	25696	0.30	0.86	1.00	1.15	29.30	1.04	0.78

Lymphocyte, %

Variable used: lympho

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	67	3	10.80	17.00	21.20	37.7	16.62	7.45
DOSE	308	89	4	11.50	16.00	21.05	48.7	17.30	8.22
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	99	6	15.62	20.20	26.00	53.9	21.29	8.03
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	86	4	16.70	22.55	28.42	81.0	23.78	10.89
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	188	5	23.00	29.00	35.00	60.0	29.13	9.15
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	137	5	20.00	26.00	32.00	60.0	26.54	9.68
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	20217	3	21.00	27.00	33.00	81.0	27.39	9.72

Marital status

Variable used: marital_status

Additional label: NA

Study	Divorced	Married	Never married	Separated	Widowed	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	303 (14.2%)	1,291 (60.6%)	240 (11.3%)	81 (3.8%)	198 (9.3%)	17 (0.8%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	566 (9.0%)	4,392 (70.0%)	431 (6.9%)	0 (0.0%)	758 (12.1%)	126 (2.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	869 (3.2%)	5,683 (20.8%)	671 (2.5%)	81 (0.3%)	956 (3.5%)	19,053 (69.8%)	27,313 (100.0%)

Myocardial infarction

Variable used: mi

Additional label: MI

Study	No	Yes	Total
ATHENA	107 (29.7%)	253 (70.3%)	360 (100.0%)
CARRESS	115 (61.2%)	73 (38.8%)	188 (100.0%)
DOSE	200 (64.9%)	108 (35.1%)	308 (100.0%)
ESCAPE	244 (56.4%)	189 (43.6%)	433 (100.0%)
EXACT	164 (64.8%)	89 (35.2%)	253 (100.0%)
FIGHT	167 (55.7%)	133 (44.3%)	300 (100.0%)
GUIDE-IT	643 (71.9%)	251 (28.1%)	894 (100.0%)
HF-ACTION	1,231 (57.8%)	899 (42.2%)	2,130 (100.0%)
INDIE-HFpEF	5 (4.8%)	100 (95.2%)	105 (100.0%)
NEAT-HFpEF	98 (89.1%)	12 (10.9%)	110 (100.0%)
RELAX	191 (88.4%)	25 (11.6%)	216 (100.0%)
ROSE	232 (64.4%)	128 (35.6%)	360 (100.0%)
SCD-HeFT	1,403 (55.7%)	1,118 (44.3%)	2,521 (100.0%)
SOLVD Prevent	846 (20.0%)	3,382 (80.0%)	4,228 (100.0%)
SOLVD Registry	2,579 (41.1%)	3,694 (58.9%)	6,273 (100.0%)
SOLVD Treat	882 (34.3%)	1,687 (65.7%)	2,569 (100.0%)
STICH	520 (19.8%)	2,100 (80.2%)	2,620 (100.0%)
TOPCAT	2,552 (74.1%)	893 (25.9%)	3,445 (100.0%)
Total	12,179 (44.6%)	15,134 (55.4%)	27,313 (100.0%)

MLHF emotional

Variable used: mlhf_emotional

Additional label: MLHF emotional

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	14	0	11	16	20	25	15.23	6.55
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	3	0	3	10	16	25	9.98	7.53
RELAX	216	0	0	3	8	14	25	9.29	6.87
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	96	0	3	8	14	25	9.04	7.08
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	24146	0	3	9	15	25	9.91	7.31

MLHF physical

Variable used: mlhf_physical

Additional label: MLHF physical

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	15	3	30.00	35	38	40	33.11	6.33
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	7	0	13.00	25	30	40	22.27	10.23
RELAX	216	2	0	15.00	22	30	40	22.07	9.94
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	122	0	10.00	19	29	40	19.19	11.32
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	24179	0	11.25	22	31	40	21.34	11.65

MLHF total

Variable used: mlhf_total

Additional label: MLHF total

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	50	4	64.50	76	87	105	74.43	17.20
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	16	0	24.50	44	61	104	44.60	23.71
RELAX	216	8	0	29.75	43	62	105	45.19	22.56
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	344	0	22.00	42	62	105	42.59	24.95
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	24451	0	26.00	47	68	105	47.11	26.15

Mitral regurgitation

Variable used: mr

Additional label: NA

Study	Normal/mild	Moderate/Severe	Normal/Mild	Unknown	Total
ATHENA	274 (76.1%)	86 (23.9%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	43 (22.9%)	55 (29.3%)	90 (47.9%)	0 (0.0%)	188 (100.0%)
DOSE	53 (17.2%)	106 (34.4%)	149 (48.4%)	0 (0.0%)	308 (100.0%)
ESCAPE	2 (0.5%)	45 (10.4%)	386 (89.1%)	0 (0.0%)	433 (100.0%)
EXACT	41 (16.2%)	83 (32.8%)	129 (51.0%)	0 (0.0%)	253 (100.0%)
FIGHT	220 (73.3%)	80 (26.7%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	175 (8.2%)	748 (35.1%)	1,207 (56.7%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	104 (99.0%)	1 (1.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	107 (97.3%)	3 (2.7%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	2 (0.9%)	32 (14.8%)	182 (84.3%)	0 (0.0%)	216 (100.0%)
ROSE	43 (11.9%)	148 (41.1%)	169 (46.9%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,155 (85.5%)	366 (14.5%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	6,157 (98.2%)	36 (0.6%)	80 (1.3%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	83 (3.2%)	462 (17.6%)	2,075 (79.2%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,019 (87.6%)	47 (1.4%)	379 (11.0%)	0 (0.0%)	3,445 (100.0%)
Total	12,478 (45.7%)	2,298 (8.4%)	4,846 (17.7%)	7,691 (28.2%)	27,313 (100.0%)

On MRA

Variable used: mra

Additional label: MRA

Study	No	Yes	Unknown	Total
ATHENA	303 (84.2%)	57 (15.8%)	0 (0.0%)	360 (100.0%)
CARRESS	150 (79.8%)	38 (20.2%)	0 (0.0%)	188 (100.0%)
DOSE	222 (72.1%)	86 (27.9%)	0 (0.0%)	308 (100.0%)
ESCAPE	247 (57.0%)	186 (43.0%)	0 (0.0%)	433 (100.0%)
EXACT	120 (47.4%)	133 (52.6%)	0 (0.0%)	253 (100.0%)
FIGHT	123 (41.0%)	177 (59.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	450 (50.3%)	444 (49.7%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,168 (54.8%)	962 (45.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	72 (68.6%)	33 (31.4%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	83 (75.5%)	27 (24.5%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	251 (69.7%)	109 (30.3%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,037 (80.8%)	484 (19.2%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	1,723 (50.0%)	1,722 (50.0%)	0 (0.0%)	3,445 (100.0%)
Total	7,165 (26.2%)	4,458 (16.3%)	15,690 (57.4%)	27,313 (100.0%)

On long-acting nitrate

Variable used: nitrate

Additional label: Nitrate

Study	No	Yes	Total
ATHENA	292 (81.1%)	68 (18.9%)	360 (100.0%)
CARRESS	128 (68.1%)	60 (31.9%)	188 (100.0%)
DOSE	217 (70.5%)	91 (29.5%)	308 (100.0%)
ESCAPE	293 (67.7%)	140 (32.3%)	433 (100.0%)
EXACT	174 (68.8%)	79 (31.2%)	253 (100.0%)
FIGHT	187 (62.3%)	113 (37.7%)	300 (100.0%)
GUIDE-IT	672 (75.2%)	222 (24.8%)	894 (100.0%)
HF-ACTION	1,617 (75.9%)	513 (24.1%)	2,130 (100.0%)
INDIE-HFpEF	105 (100.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	108 (98.2%)	2 (1.8%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	216 (100.0%)
ROSE	270 (75.0%)	90 (25.0%)	360 (100.0%)
SCD-HeFT	1,786 (70.8%)	735 (29.2%)	2,521 (100.0%)
SOLVD Prevent	2,945 (69.7%)	1,283 (30.3%)	4,228 (100.0%)
SOLVD Registry	3,606 (57.5%)	2,667 (42.5%)	6,273 (100.0%)
SOLVD Treat	1,496 (58.2%)	1,073 (41.8%)	2,569 (100.0%)
STICH	1,202 (45.9%)	1,418 (54.1%)	2,620 (100.0%)
TOPCAT	2,931 (85.1%)	514 (14.9%)	3,445 (100.0%)
Total	18,245 (66.8%)	9,068 (33.2%)	27,313 (100.0%)

NTBNP value

Variable used: ntbnp_val

Additional label: NTBNP, pg/ml

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	7	302.60	2299.00	4102.6	8656.70	54482.6	6419.00	6598.05
CARRESS	188	6	40.30	1617.50	4343.5	9596.25	70000.0	7380.03	9477.05
DOSE	308	17	47.19	2456.00	4461.0	9894.50	53694.0	7438.83	7318.68
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	8	20.78	1112.00	2457.0	4451.00	24999.0	3720.07	4041.62
FIGHT	300	241	470.00	1957.00	3789.0	9010.00	36400.0	7686.75	9443.68
GUIDE-IT	894	41	49.00	1462.00	2605.0	5247.00	104280.0	4686.58	7012.54
HF-ACTION	2130	2056	99.00	471.25	1073.0	4576.00	29267.0	3507.76	5601.97
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	0	18.65	104.60	227.2	604.03	4537.0	522.68	773.63
RELAX	216	80	16.20	398.25	728.5	1639.50	9071.0	1256.59	1438.54
ROSE	360	161	57.00	2434.00	5323.0	10631.50	60000.0	8416.84	9054.30
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	2824	13.00	463.00	843.0	1720.00	23392.0	1511.25	2188.05
Overall	27313	24190	13.00	943.50	2316.0	5205.00	104280.0	4559.00	6647.03

NYHA

Variable used: nyha

Additional label: NYHA

Study	I-II	III-IV	Unknown	Total
ATHENA	51 (14.2%)	302 (83.9%)	7 (1.9%)	360 (100.0%)
CARRESS	0 (0.0%)	180 (95.7%)	8 (4.3%)	188 (100.0%)
DOSE	12 (3.9%)	265 (86.0%)	31 (10.1%)	308 (100.0%)
ESCAPE	0 (0.0%)	430 (99.3%)	3 (0.7%)	433 (100.0%)
EXACT	120 (47.4%)	133 (52.6%)	0 (0.0%)	253 (100.0%)
FIGHT	90 (30.0%)	203 (67.7%)	7 (2.3%)	300 (100.0%)
GUIDE-IT	506 (56.6%)	375 (41.9%)	13 (1.5%)	894 (100.0%)
HF-ACTION	1,351 (63.4%)	779 (36.6%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	59 (53.6%)	51 (46.4%)	0 (0.0%)	110 (100.0%)
RELAX	101 (46.8%)	115 (53.2%)	0 (0.0%)	216 (100.0%)
ROSE	16 (4.4%)	328 (91.1%)	16 (4.4%)	360 (100.0%)
SCD-HeFT	1,761 (69.9%)	760 (30.1%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	4,220 (99.8%)	5 (0.1%)	3 (0.1%)	4,228 (100.0%)
SOLVD Registry	733 (11.7%)	150 (2.4%)	5,390 (85.9%)	6,273 (100.0%)
SOLVD Treat	1,740 (67.7%)	828 (32.2%)	1 (0.0%)	2,569 (100.0%)
STICH	1,465 (55.9%)	1,139 (43.5%)	16 (0.6%)	2,620 (100.0%)
TOPCAT	2,303 (66.9%)	1,136 (33.0%)	6 (0.2%)	3,445 (100.0%)
Total	14,528 (53.2%)	7,179 (26.3%)	5,606 (20.5%)	27,313 (100.0%)

On oral anticoagulation

Variable used: oac

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	360 (100.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	102 (54.3%)	86 (45.7%)	0 (0.0%)	188 (100.0%)
DOSE	172 (55.8%)	136 (44.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	263 (60.7%)	170 (39.3%)	0 (0.0%)	433 (100.0%)
EXACT	129 (51.0%)	124 (49.0%)	0 (0.0%)	253 (100.0%)
FIGHT	177 (59.0%)	123 (41.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	575 (64.3%)	319 (35.7%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,338 (62.8%)	792 (37.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	62 (59.0%)	43 (41.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	84 (76.4%)	26 (23.6%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	195 (54.2%)	165 (45.8%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,664 (66.0%)	857 (34.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	502 (11.9%)	3,726 (88.1%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	410 (16.0%)	2,159 (84.0%)	0 (0.0%)	2,569 (100.0%)
STICH	2,298 (87.7%)	322 (12.3%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	2,658 (77.2%)	787 (22.8%)	0 (0.0%)	3,445 (100.0%)
Total	11,205 (41.0%)	9,835 (36.0%)	6,273 (23.0%)	27,313 (100.0%)

On oral hypoglycemic

Variable used: oral_hypog

Additional label: Oral hypoglycemic

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	148 (78.7%)	40 (21.3%)	0 (0.0%)	188 (100.0%)
DOSE	240 (77.9%)	68 (22.1%)	0 (0.0%)	308 (100.0%)
ESCAPE	349 (80.6%)	84 (19.4%)	0 (0.0%)	433 (100.0%)
EXACT	181 (71.5%)	72 (28.5%)	0 (0.0%)	253 (100.0%)
FIGHT	294 (98.0%)	6 (2.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	666 (74.5%)	228 (25.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,705 (80.0%)	425 (20.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	84 (76.4%)	26 (23.6%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	302 (83.9%)	58 (16.1%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,044 (81.1%)	477 (18.9%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,047 (78.1%)	573 (21.9%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	2,483 (72.1%)	962 (27.9%)	0 (0.0%)	3,445 (100.0%)
Total	10,759 (39.4%)	3,019 (11.1%)	13,535 (49.6%)	27,313 (100.0%)

Orthopnea for congestion score

Variable used: orthopnea_ccs

Additional label: NA

Study	0	1	2	3	Unknown	Total
ATHENA	49 (13.6%)	61 (16.9%)	144 (40.0%)	100 (27.8%)	6 (1.7%)	360 (100.0%)
CARRESS	9 (4.8%)	22 (11.7%)	59 (31.4%)	88 (46.8%)	10 (5.3%)	188 (100.0%)
DOSE	27 (8.8%)	38 (12.3%)	111 (36.0%)	118 (38.3%)	14 (4.5%)	308 (100.0%)
ESCAPE	31 (7.2%)	35 (8.1%)	303 (70.0%)	62 (14.3%)	2 (0.5%)	433 (100.0%)
EXACT	59 (23.3%)	67 (26.5%)	86 (34.0%)	38 (15.0%)	3 (1.2%)	253 (100.0%)
FIGHT	120 (40.0%)	48 (16.0%)	78 (26.0%)	38 (12.7%)	16 (5.3%)	300 (100.0%)
GUIDE-IT	265 (29.6%)	252 (28.2%)	225 (25.2%)	106 (11.9%)	46 (5.1%)	894 (100.0%)
HF-ACTION	1,562 (73.3%)	143 (6.7%)	216 (10.1%)	202 (9.5%)	7 (0.3%)	2,130 (100.0%)
INDIE-HFpEF	58 (55.2%)	16 (15.2%)	14 (13.3%)	15 (14.3%)	2 (1.9%)	105 (100.0%)
NEAT-HFpEF	52 (47.3%)	27 (24.5%)	22 (20.0%)	8 (7.3%)	1 (0.9%)	110 (100.0%)
RELAX	72 (33.3%)	56 (25.9%)	53 (24.5%)	21 (9.7%)	14 (6.5%)	216 (100.0%)
ROSE	36 (10.0%)	55 (15.3%)	138 (38.3%)	114 (31.7%)	17 (4.7%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	1,834 (72.7%)	687 (27.3%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	3,971 (93.9%)	252 (6.0%)	0 (0.0%)	5 (0.1%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	1,454 (56.6%)	1,114 (43.4%)	0 (0.0%)	1 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,186 (63.5%)	380 (11.0%)	502 (14.6%)	331 (9.6%)	46 (1.3%)	3,445 (100.0%)
Total	4,526 (16.6%)	8,459 (31.0%)	4,004 (14.7%)	1,241 (4.5%)	9,083 (33.3%)	27,313 (100.0%)

Obstructive sleep apnea

Variable used: osa

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	278 (77.2%)	82 (22.8%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	185 (61.7%)	115 (38.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	693 (77.5%)	201 (22.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	40 (38.1%)	65 (61.9%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	53 (48.2%)	57 (51.8%)	0 (0.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,249 (4.6%)	520 (1.9%)	25,544 (93.5%)	27,313 (100.0%)

On other lipid lowering agent

Variable used: other_lipid_med

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	336 (93.3%)	24 (6.7%)	0 (0.0%)	360 (100.0%)
CARRESS	157 (83.5%)	31 (16.5%)	0 (0.0%)	188 (100.0%)
DOSE	95 (30.8%)	213 (69.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	406 (93.8%)	27 (6.2%)	0 (0.0%)	433 (100.0%)
EXACT	210 (83.0%)	43 (17.0%)	0 (0.0%)	253 (100.0%)
FIGHT	278 (92.7%)	22 (7.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	840 (94.0%)	54 (6.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	95 (90.5%)	10 (9.5%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	89 (80.9%)	21 (19.1%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,722 (10.0%)	445 (1.6%)	24,146 (88.4%)	27,313 (100.0%)

On P2Y12 inhibitor

Variable used: p2y12

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	360 (100.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	165 (87.8%)	23 (12.2%)	0 (0.0%)	188 (100.0%)
DOSE	267 (86.7%)	41 (13.3%)	0 (0.0%)	308 (100.0%)
ESCAPE	406 (93.8%)	27 (6.2%)	0 (0.0%)	433 (100.0%)
EXACT	229 (90.5%)	24 (9.5%)	0 (0.0%)	253 (100.0%)
FIGHT	295 (98.3%)	5 (1.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	885 (99.0%)	9 (1.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,874 (88.0%)	256 (12.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	104 (99.0%)	1 (1.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	105 (95.5%)	5 (4.5%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,274 (86.8%)	346 (13.2%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	7,180 (26.3%)	737 (2.7%)	19,396 (71.0%)	27,313 (100.0%)

Prior PCI

Variable used: pci

Additional label: PCI

Study	No	Yes	Total
ATHENA	280 (77.8%)	80 (22.2%)	360 (100.0%)
CARRESS	135 (71.8%)	53 (28.2%)	188 (100.0%)
DOSE	245 (79.5%)	63 (20.5%)	308 (100.0%)
ESCAPE	335 (77.4%)	98 (22.6%)	433 (100.0%)
EXACT	202 (79.8%)	51 (20.2%)	253 (100.0%)
FIGHT	203 (67.7%)	97 (32.3%)	300 (100.0%)
GUIDE-IT	726 (81.2%)	168 (18.8%)	894 (100.0%)
HF-ACTION	1,632 (76.6%)	498 (23.4%)	2,130 (100.0%)
INDIE-HFpEF	86 (81.9%)	19 (18.1%)	105 (100.0%)
NEAT-HFpEF	98 (89.1%)	12 (10.9%)	110 (100.0%)
RELAX	182 (84.3%)	34 (15.7%)	216 (100.0%)
ROSE	273 (75.8%)	87 (24.2%)	360 (100.0%)
SCD-HeFT	2,005 (79.5%)	516 (20.5%)	2,521 (100.0%)
SOLVD Prevent	3,937 (93.1%)	291 (6.9%)	4,228 (100.0%)
SOLVD Registry	5,940 (94.7%)	333 (5.3%)	6,273 (100.0%)
SOLVD Treat	2,510 (97.7%)	59 (2.3%)	2,569 (100.0%)
STICH	2,208 (84.3%)	412 (15.7%)	2,620 (100.0%)
TOPCAT	2,945 (85.5%)	500 (14.5%)	3,445 (100.0%)
Total	23,942 (87.7%)	3,371 (12.3%)	27,313 (100.0%)

piiinp

Variable used: piiinp

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	3.25	8.07	10.33	13.49	30.05	11.40	4.76
DOSE	308	27	2.79	7.75	9.84	12.25	41.59	10.77	4.64
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	2	2.94	6.07	7.69	9.97	50.00	8.67	4.70
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26636	2.79	7.15	9.06	11.96	50.00	10.28	4.82

Pacemaker

Variable used: ppm

Additional label: PPM

Study	No	Yes	Total
ATHENA	210 (58.3%)	150 (41.7%)	360 (100.0%)
CARRESS	144 (76.6%)	44 (23.4%)	188 (100.0%)
DOSE	224 (72.7%)	84 (27.3%)	308 (100.0%)
ESCAPE	331 (76.4%)	102 (23.6%)	433 (100.0%)
EXACT	168 (66.4%)	85 (33.6%)	253 (100.0%)
FIGHT	59 (19.7%)	241 (80.3%)	300 (100.0%)
GUIDE-IT	706 (79.0%)	188 (21.0%)	894 (100.0%)
HF-ACTION	1,745 (81.9%)	385 (18.1%)	2,130 (100.0%)
INDIE-HFpEF	91 (86.7%)	14 (13.3%)	105 (100.0%)
NEAT-HFpEF	102 (92.7%)	8 (7.3%)	110 (100.0%)
RELAX	182 (84.3%)	34 (15.7%)	216 (100.0%)
ROSE	316 (87.8%)	44 (12.2%)	360 (100.0%)
SCD-HeFT	2,521 (100.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	4,112 (97.3%)	116 (2.7%)	4,228 (100.0%)
SOLVD Registry	5,942 (94.7%)	331 (5.3%)	6,273 (100.0%)
SOLVD Treat	2,454 (95.5%)	115 (4.5%)	2,569 (100.0%)
STICH	2,620 (100.0%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,176 (92.2%)	269 (7.8%)	3,445 (100.0%)
Total	25,103 (91.9%)	2,210 (8.1%)	27,313 (100.0%)

Prior HF hospitalization

Variable used: prior_hfh

Additional label: Prior HFH

Study	No	Yes	Unknown	Total
ATHENA	126 (35.0%)	234 (65.0%)	0 (0.0%)	360 (100.0%)
CARRESS	45 (23.9%)	143 (76.1%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	308 (100.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	433 (100.0%)	0 (0.0%)	433 (100.0%)
EXACT	109 (43.1%)	144 (56.9%)	0 (0.0%)	253 (100.0%)
FIGHT	38 (12.7%)	262 (87.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	894 (100.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	82 (78.1%)	23 (21.9%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	110 (100.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	360 (100.0%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	956 (27.8%)	2,489 (72.2%)	0 (0.0%)	3,445 (100.0%)
Total	4,706 (17.2%)	4,396 (16.1%)	18,211 (66.7%)	27,313 (100.0%)

Pulse pressure

Variable used: pupr

Additional label: NA

Study	< 30	30-40	40+	Unknown	Total
ATHENA	37 (10.3%)	79 (21.9%)	242 (67.2%)	2 (0.6%)	360 (100.0%)
CARRESS	10 (5.3%)	38 (20.2%)	139 (73.9%)	1 (0.5%)	188 (100.0%)
DOSE	26 (8.4%)	80 (26.0%)	201 (65.3%)	1 (0.3%)	308 (100.0%)
ESCAPE	88 (20.3%)	184 (42.5%)	158 (36.5%)	3 (0.7%)	433 (100.0%)
EXACT	33 (13.0%)	100 (39.5%)	120 (47.4%)	0 (0.0%)	253 (100.0%)
FIGHT	34 (11.3%)	107 (35.7%)	157 (52.3%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	96 (10.7%)	319 (35.7%)	474 (53.0%)	5 (0.6%)	894 (100.0%)
HF-ACTION	231 (10.8%)	808 (37.9%)	1,086 (51.0%)	5 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	11 (10.5%)	94 (89.5%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	11 (10.0%)	99 (90.0%)	0 (0.0%)	110 (100.0%)
RELAX	3 (1.4%)	18 (8.3%)	195 (90.3%)	0 (0.0%)	216 (100.0%)
ROSE	22 (6.1%)	83 (23.1%)	255 (70.8%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	160 (6.3%)	768 (30.5%)	1,584 (62.8%)	9 (0.4%)	2,521 (100.0%)
SOLVD Prevent	217 (5.1%)	1,379 (32.6%)	2,625 (62.1%)	7 (0.2%)	4,228 (100.0%)
SOLVD Registry	289 (4.6%)	1,859 (29.6%)	3,905 (62.3%)	220 (3.5%)	6,273 (100.0%)
SOLVD Treat	182 (7.1%)	755 (29.4%)	1,625 (63.3%)	7 (0.3%)	2,569 (100.0%)
STICH	127 (4.8%)	1,001 (38.2%)	1,476 (56.3%)	16 (0.6%)	2,620 (100.0%)
TOPCAT	30 (0.9%)	583 (16.9%)	2,828 (82.1%)	4 (0.1%)	3,445 (100.0%)
Total	1,585 (5.8%)	8,183 (30.0%)	17,263 (63.2%)	282 (1.0%)	27,313 (100.0%)

Pulse pressure value

Variable used: pupr_val

Additional label: Pulse pressure , mm Hg

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	2	13	38.00	47	61.00	114	49.91	17.33
CARRESS	188	1	17	40.00	50	62.00	106	51.49	16.50
DOSE	308	1	12	37.00	48	60.00	118	50.14	18.09
ESCAPE	433	3	10	30.00	38	46.00	103	38.92	12.95
EXACT	253	0	14	33.00	40	50.00	91	42.85	13.67
FIGHT	300	2	5	33.00	41	50.00	93	42.67	12.96
GUIDE-IT	894	5	8	35.00	42	52.00	129	45.05	14.90
HF-ACTION	2130	5	8	34.00	42	50.00	100	43.57	13.48
INDIE-HFpEF	105	0	32	46.00	56	64.00	116	57.45	15.27
NEAT-HFpEF	110	0	31	47.25	57	69.75	98	58.94	15.57
RELAX	216	0	20	47.75	57	68.00	116	57.84	16.04
ROSE	360	0	15	39.00	50	61.00	102	51.28	16.25
SCD-HeFT	2521	9	10	38.00	46	58.00	135	48.58	15.55
SOLVD Prevent	4228	7	12	38.00	46	56.00	108	47.45	13.33
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	7	-13	38.00	48	58.00	106	48.08	14.72
STICH	2620	16	0	40.00	45	55.00	127	47.24	14.08
TOPCAT	3445	4	20	45.00	50	60.00	135	53.44	12.32
Overall	27313	6335	-13	40.00	48	58.00	135	48.23	14.51

Peripheral vascular disease

Variable used: pvd

Additional label: PVD

Study	No	Yes	Unknown	Total
ATHENA	316 (87.8%)	44 (12.2%)	0 (0.0%)	360 (100.0%)
CARRESS	150 (79.8%)	38 (20.2%)	0 (0.0%)	188 (100.0%)
DOSE	261 (84.7%)	47 (15.3%)	0 (0.0%)	308 (100.0%)
ESCAPE	379 (87.5%)	54 (12.5%)	0 (0.0%)	433 (100.0%)
EXACT	221 (87.4%)	32 (12.6%)	0 (0.0%)	253 (100.0%)
FIGHT	264 (88.0%)	36 (12.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	800 (89.5%)	94 (10.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,984 (93.1%)	146 (6.9%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	101 (96.2%)	4 (3.8%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	104 (94.5%)	6 (5.5%)	0 (0.0%)	110 (100.0%)
RELAX	185 (85.6%)	31 (14.4%)	0 (0.0%)	216 (100.0%)
ROSE	309 (85.8%)	51 (14.2%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	5,543 (88.4%)	730 (11.6%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,204 (84.1%)	416 (15.9%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,126 (90.7%)	319 (9.3%)	0 (0.0%)	3,445 (100.0%)
Total	15,947 (58.4%)	2,048 (7.5%)	9,318 (34.1%)	27,313 (100.0%)

QRS > 120 ms

Variable used: qrs_120

Additional label: QRS > 120

Study	< 120	> 120	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	90 (47.9%)	93 (49.5%)	5 (2.7%)	188 (100.0%)
DOSE	153 (49.7%)	144 (46.8%)	11 (3.6%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	88 (34.8%)	134 (53.0%)	31 (12.3%)	253 (100.0%)
FIGHT	300 (100.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	1,031 (48.4%)	750 (35.2%)	349 (16.4%)	2,130 (100.0%)
INDIE-HFpEF	105 (100.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	92 (83.6%)	17 (15.5%)	1 (0.9%)	110 (100.0%)
RELAX	150 (69.4%)	46 (21.3%)	20 (9.3%)	216 (100.0%)
ROSE	130 (36.1%)	212 (58.9%)	18 (5.0%)	360 (100.0%)
SCD-HeFT	1,487 (59.0%)	905 (35.9%)	129 (5.1%)	2,521 (100.0%)
SOLVD Prevent	2,433 (57.5%)	1,245 (29.4%)	550 (13.0%)	4,228 (100.0%)
SOLVD Registry	4,190 (66.8%)	1,306 (20.8%)	777 (12.4%)	6,273 (100.0%)
SOLVD Treat	1,238 (48.2%)	663 (25.8%)	668 (26.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,813 (81.7%)	523 (15.2%)	109 (3.2%)	3,445 (100.0%)
Total	14,300 (52.4%)	6,038 (22.1%)	6,975 (25.5%)	27,313 (100.0%)

QRS interval

Variable used: qrs_val

Additional label: NA

Study	< 120	> 120	120-150	150+	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	90 (47.9%)	93 (49.5%)	0 (0.0%)	0 (0.0%)	5 (2.7%)	188 (100.0%)
DOSE	202 (65.6%)	93 (30.2%)	0 (0.0%)	0 (0.0%)	13 (4.2%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	88 (34.8%)	60 (23.7%)	77 (30.4%)	28 (11.1%)	253 (100.0%)
FIGHT	300 (100.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	1,031 (48.4%)	0 (0.0%)	557 (26.2%)	517 (24.3%)	25 (1.2%)	2,130 (100.0%)
INDIE-HFpEF	105 (100.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	92 (83.6%)	0 (0.0%)	9 (8.2%)	9 (8.2%)	0 (0.0%)	110 (100.0%)
RELAX	150 (69.4%)	0 (0.0%)	20 (9.3%)	31 (14.4%)	15 (6.9%)	216 (100.0%)
ROSE	130 (36.1%)	0 (0.0%)	86 (23.9%)	132 (36.7%)	12 (3.3%)	360 (100.0%)
SCD-HeFT	1,487 (59.0%)	0 (0.0%)	550 (21.8%)	483 (19.2%)	1 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,813 (81.7%)	0 (0.0%)	367 (10.7%)	246 (7.1%)	19 (0.6%)	3,445 (100.0%)
Total	6,400 (23.4%)	274 (1.0%)	1,649 (6.0%)	1,495 (5.5%)	17,495 (64.1%)	27,313 (100.0%)

Race

Variable used: race

Additional label: Race

Study	Asian	Black	Hispanic	Other	White	Unknown	Total
ATHENA	0 (0.0%)	151 (41.9%)	0 (0.0%)	9 (2.5%)	200 (55.6%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	44 (23.4%)	12 (6.4%)	3 (1.6%)	129 (68.6%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	76 (24.7%)	13 (4.2%)	8 (2.6%)	211 (68.5%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	119 (27.5%)	46 (10.6%)	10 (2.3%)	258 (59.6%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	74 (29.2%)	0 (0.0%)	10 (4.0%)	169 (66.8%)	0 (0.0%)	253 (100.0%)
FIGHT	0 (0.0%)	115 (38.3%)	15 (5.0%)	11 (3.7%)	159 (53.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	27 (3.0%)	318 (35.6%)	58 (6.5%)	26 (2.9%)	459 (51.3%)	6 (0.7%)	894 (100.0%)
HF-ACTION	107 (5.0%)	669 (31.4%)	0 (0.0%)	32 (1.5%)	1,322 (62.1%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	13 (12.4%)	0 (0.0%)	0 (0.0%)	92 (87.6%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	9 (8.2%)	5 (4.5%)	3 (2.7%)	93 (84.5%)	0 (0.0%)	110 (100.0%)
RELAX	0 (0.0%)	8 (3.7%)	0 (0.0%)	11 (5.1%)	197 (91.2%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	73 (20.3%)	0 (0.0%)	9 (2.5%)	262 (72.8%)	16 (4.4%)	360 (100.0%)
SCD-HeFT	30 (1.2%)	425 (16.9%)	111 (4.4%)	23 (0.9%)	1,932 (76.6%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	404 (9.6%)	0 (0.0%)	162 (3.8%)	3,658 (86.5%)	4 (0.1%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	696 (11.1%)	52 (0.8%)	147 (2.3%)	5,369 (85.6%)	9 (0.1%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	396 (15.4%)	0 (0.0%)	112 (4.4%)	2,061 (80.2%)	0 (0.0%)	2,569 (100.0%)
STICH	244 (9.3%)	75 (2.9%)	114 (4.4%)	165 (6.3%)	2,019 (77.1%)	3 (0.1%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	269 (7.8%)	321 (9.3%)	31 (0.9%)	2,824 (82.0%)	0 (0.0%)	3,445 (100.0%)
Total	408 (1.5%)	3,934 (14.4%)	747 (2.7%)	772 (2.8%)	21,414 (78.4%)	38 (0.1%)	27,313 (100.0%)

Rales

Variable used: rales

Additional label: Rales

Study	No	Yes	Unknown	Total
ATHENA	146 (40.6%)	211 (58.6%)	3 (0.8%)	360 (100.0%)
CARRESS	87 (46.3%)	101 (53.7%)	0 (0.0%)	188 (100.0%)
DOSE	128 (41.6%)	178 (57.8%)	2 (0.6%)	308 (100.0%)
ESCAPE	206 (47.6%)	227 (52.4%)	0 (0.0%)	433 (100.0%)
EXACT	240 (94.9%)	13 (5.1%)	0 (0.0%)	253 (100.0%)
FIGHT	263 (87.7%)	35 (11.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	779 (87.1%)	100 (11.2%)	15 (1.7%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	102 (97.1%)	3 (2.9%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	108 (98.2%)	2 (1.8%)	0 (0.0%)	110 (100.0%)
RELAX	202 (93.5%)	14 (6.5%)	0 (0.0%)	216 (100.0%)
ROSE	157 (43.6%)	197 (54.7%)	6 (1.7%)	360 (100.0%)
SCD-HeFT	2,350 (93.2%)	167 (6.6%)	4 (0.2%)	2,521 (100.0%)
SOLVD Prevent	4,110 (97.2%)	107 (2.5%)	11 (0.3%)	4,228 (100.0%)
SOLVD Registry	4,069 (64.9%)	2,001 (31.9%)	203 (3.2%)	6,273 (100.0%)
SOLVD Treat	2,254 (87.7%)	308 (12.0%)	7 (0.3%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,879 (83.6%)	521 (15.1%)	45 (1.3%)	3,445 (100.0%)
Total	18,080 (66.2%)	4,185 (15.3%)	5,048 (18.5%)	27,313 (100.0%)

Rales for congestion score

Variable used: rales_ccs

Additional label: NA

Study	0	1	2	3	Unknown	Total
ATHENA	146 (40.6%)	155 (43.1%)	51 (14.2%)	5 (1.4%)	3 (0.8%)	360 (100.0%)
CARRESS	87 (46.3%)	75 (39.9%)	24 (12.8%)	2 (1.1%)	0 (0.0%)	188 (100.0%)
DOSE	128 (41.6%)	138 (44.8%)	37 (12.0%)	3 (1.0%)	2 (0.6%)	308 (100.0%)
ESCAPE	206 (47.6%)	165 (38.1%)	61 (14.1%)	1 (0.2%)	0 (0.0%)	433 (100.0%)
EXACT	240 (94.9%)	12 (4.7%)	1 (0.4%)	0 (0.0%)	0 (0.0%)	253 (100.0%)
FIGHT	263 (87.7%)	32 (10.7%)	3 (1.0%)	0 (0.0%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	779 (87.1%)	90 (10.1%)	8 (0.9%)	2 (0.2%)	15 (1.7%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	102 (97.1%)	3 (2.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	108 (98.2%)	2 (1.8%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	202 (93.5%)	13 (6.0%)	1 (0.5%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	157 (43.6%)	146 (40.6%)	49 (13.6%)	2 (0.6%)	6 (1.7%)	360 (100.0%)
SCD-HeFT	2,350 (93.2%)	154 (6.1%)	13 (0.5%)	0 (0.0%)	4 (0.2%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	4,110 (97.2%)	107 (2.5%)	0 (0.0%)	11 (0.3%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	4,069 (64.9%)	2,001 (31.9%)	0 (0.0%)	203 (3.2%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	2,254 (87.7%)	308 (12.0%)	0 (0.0%)	7 (0.3%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	2,879 (83.6%)	521 (15.1%)	0 (0.0%)	45 (1.3%)	3,445 (100.0%)
Total	4,768 (17.5%)	14,297 (52.3%)	3,185 (11.7%)	15 (0.1%)	5,048 (18.5%)	27,313 (100.0%)

Randomization group

Variable used: rand_group

Additional label: NA

Study	Intervention	Intervention 2	Standard care	Unknown	Total
ATHENA	43 (11.9%)	182 (50.6%)	135 (37.5%)	0 (0.0%)	360 (100.0%)
CARRESS	94 (50.0%)	0 (0.0%)	94 (50.0%)	0 (0.0%)	188 (100.0%)
DOSE	152 (49.4%)	0 (0.0%)	156 (50.6%)	0 (0.0%)	308 (100.0%)
ESCAPE	215 (49.7%)	0 (0.0%)	218 (50.3%)	0 (0.0%)	433 (100.0%)
EXACT	128 (50.6%)	0 (0.0%)	125 (49.4%)	0 (0.0%)	253 (100.0%)
FIGHT	146 (48.7%)	0 (0.0%)	154 (51.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	446 (49.9%)	0 (0.0%)	448 (50.1%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,060 (49.8%)	0 (0.0%)	1,070 (50.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	52 (49.5%)	0 (0.0%)	53 (50.5%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	51 (46.4%)	59 (53.6%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	113 (52.3%)	0 (0.0%)	103 (47.7%)	0 (0.0%)	216 (100.0%)
ROSE	122 (33.9%)	119 (33.1%)	119 (33.1%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	829 (32.9%)	845 (33.5%)	847 (33.6%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	2,110 (49.9%)	0 (0.0%)	2,117 (50.1%)	1 (0.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,270 (100.0%)	3 (0.0%)	6,273 (100.0%)
SOLVD Treat	1,285 (50.0%)	0 (0.0%)	1,283 (49.9%)	1 (0.0%)	2,569 (100.0%)
STICH	1,033 (39.4%)	501 (19.1%)	602 (23.0%)	484 (18.5%)	2,620 (100.0%)
TOPCAT	1,722 (50.0%)	0 (0.0%)	1,723 (50.0%)	0 (0.0%)	3,445 (100.0%)
Total	9,601 (35.2%)	1,706 (6.2%)	15,517 (56.8%)	489 (1.8%)	27,313 (100.0%)

RBBB

Variable used: rbbb

Additional label: RBBB

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	394 (91.0%)	39 (9.0%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	2,053 (96.4%)	77 (3.6%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	2,447 (9.0%)	116 (0.4%)	24,750 (90.6%)	27,313 (100.0%)

Region

Variable used: region

Additional label: Region

Study	Central Europe	Latin America	North America	Western Europe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	542 (20.7%)	1,367 (52.2%)	711 (27.1%)	2,620 (100.0%)
TOPCAT	1,678 (48.7%)	290 (8.4%)	1,477 (42.9%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)
Total	1,678 (6.1%)	290 (1.1%)	5,076 (18.6%)	1,367 (5.0%)	18,902 (69.2%)	27,313 (100.0%)

Revascularization

Variable used: revasc

Additional label: CABG or PCI

Study	No	Yes	Total
ATHENA	246 (68.3%)	114 (31.7%)	360 (100.0%)
CARRESS	102 (54.3%)	86 (45.7%)	188 (100.0%)
DOSE	177 (57.5%)	131 (42.5%)	308 (100.0%)
ESCAPE	262 (60.5%)	171 (39.5%)	433 (100.0%)
EXACT	145 (57.3%)	108 (42.7%)	253 (100.0%)
FIGHT	166 (55.3%)	134 (44.7%)	300 (100.0%)
GUIDE-IT	629 (70.4%)	265 (29.6%)	894 (100.0%)
HF-ACTION	1,302 (61.1%)	828 (38.9%)	2,130 (100.0%)
INDIE-HFpEF	80 (76.2%)	25 (23.8%)	105 (100.0%)
NEAT-HFpEF	89 (80.9%)	21 (19.1%)	110 (100.0%)
RELAX	161 (74.5%)	55 (25.5%)	216 (100.0%)
ROSE	195 (54.2%)	165 (45.8%)	360 (100.0%)
SCD-HeFT	1,576 (62.5%)	945 (37.5%)	2,521 (100.0%)
SOLVD Prevent	3,075 (72.7%)	1,153 (27.3%)	4,228 (100.0%)
SOLVD Registry	4,600 (73.3%)	1,673 (26.7%)	6,273 (100.0%)
SOLVD Treat	2,078 (80.9%)	491 (19.1%)	2,569 (100.0%)
STICH	2,140 (81.7%)	480 (18.3%)	2,620 (100.0%)
TOPCAT	2,632 (76.4%)	813 (23.6%)	3,445 (100.0%)
Total	19,655 (72.0%)	7,658 (28.0%)	27,313 (100.0%)

RV function

Variable used: rv_function

Additional label: RV function

Study	Mild	Moderate	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	180 (41.6%)	1 (0.2%)	252 (58.2%)	433 (100.0%)
EXACT	61 (24.1%)	54 (21.3%)	91 (36.0%)	19 (7.5%)	28 (11.1%)	253 (100.0%)
FIGHT	72 (24.0%)	96 (32.0%)	66 (22.0%)	27 (9.0%)	39 (13.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	4 (3.6%)	2 (1.8%)	77 (70.0%)	1 (0.9%)	26 (23.6%)	110 (100.0%)
RELAX	22 (10.2%)	16 (7.4%)	167 (77.3%)	1 (0.5%)	10 (4.6%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	57 (0.9%)	57 (0.9%)	584 (9.3%)	16 (0.3%)	5,559 (88.6%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	237 (9.0%)	156 (6.0%)	1,388 (53.0%)	58 (2.2%)	781 (29.8%)	2,620 (100.0%)
TOPCAT	10 (0.3%)	1 (0.0%)	477 (13.8%)	0 (0.0%)	2,957 (85.8%)	3,445 (100.0%)
Total	463 (1.7%)	382 (1.4%)	3,030 (11.1%)	123 (0.5%)	23,315 (85.4%)	27,313 (100.0%)

RV function - TOPCAT tertile

Variable used: rv_function_topcat

Additional label: RV function, TOPCAT

Study	Tertile 1	Tertile 2	Tertile 3	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	211 (6.1%)	134 (3.9%)	143 (4.2%)	2,957 (85.8%)	3,445 (100.0%)
Total	211 (0.8%)	134 (0.5%)	143 (0.5%)	26,825 (98.2%)	27,313 (100.0%)

RV end diastolic area

Variable used: rveda

Additional label: RV EDA

Study	Enlarged	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	100 (23.1%)	76 (17.6%)	257 (59.4%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	82 (2.4%)	406 (11.8%)	2,957 (85.8%)	3,445 (100.0%)
Total	182 (0.7%)	482 (1.8%)	26,649 (97.6%)	27,313 (100.0%)

RV systolic pressure

Variable used: rvsp

Additional label: RVSP

Study	Mild/mod	Normal	Severe	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	79 (18.2%)	31 (7.2%)	62 (14.3%)	261 (60.3%)	433 (100.0%)
EXACT	81 (32.0%)	40 (15.8%)	48 (19.0%)	84 (33.2%)	253 (100.0%)
FIGHT	96 (32.0%)	59 (19.7%)	82 (27.3%)	63 (21.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	11 (10.0%)	35 (31.8%)	2 (1.8%)	62 (56.4%)	110 (100.0%)
RELAX	53 (24.5%)	47 (21.8%)	38 (17.6%)	78 (36.1%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	13 (0.2%)	17 (0.3%)	12 (0.2%)	6,231 (99.3%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	114 (4.4%)	175 (6.7%)	141 (5.4%)	2,190 (83.6%)	2,620 (100.0%)
TOPCAT	83 (2.4%)	116 (3.4%)	38 (1.1%)	3,208 (93.1%)	3,445 (100.0%)
Total	530 (1.9%)	520 (1.9%)	423 (1.5%)	25,840 (94.6%)	27,313 (100.0%)

RV systolic pressure value

Variable used: rvsp_val

Additional label: RVSP, mm Hg

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	261	13.01	38.62	45.47	55.84	85.44	47.50	13.04
EXACT	253	83	16.76	36.36	43.24	51.00	93.36	44.01	13.04
FIGHT	300	63	20.24	36.16	43.64	53.56	87.24	45.35	12.96
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	62	17.96	27.47	31.22	36.80	80.84	32.80	10.48
RELAX	216	78	19.44	33.04	41.36	50.96	74.00	42.98	12.24
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2190	17.96	30.00	38.64	53.56	91.44	42.78	15.49
TOPCAT	3445	3208	20.27	29.85	36.42	44.27	86.08	38.75	12.16
Overall	27313	25881	13.01	32.04	41.00	51.36	93.36	42.94	13.87

Relative wall thickness

Variable used: rwt

Additional label: Rel wall thickness

Study	Abnormal	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	22 (5.1%)	259 (59.8%)	152 (35.1%)	433 (100.0%)
EXACT	9 (3.6%)	204 (80.6%)	40 (15.8%)	253 (100.0%)
FIGHT	20 (6.7%)	245 (81.7%)	35 (11.7%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	34 (30.9%)	72 (65.5%)	4 (3.6%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	151 (2.4%)	632 (10.1%)	5,490 (87.5%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	111 (4.2%)	1,271 (48.5%)	1,238 (47.3%)	2,620 (100.0%)
TOPCAT	487 (14.1%)	146 (4.2%)	2,812 (81.6%)	3,445 (100.0%)
Total	834 (3.1%)	2,829 (10.4%)	23,650 (86.6%)	27,313 (100.0%)

S3 gallop

Variable used: s3

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	153 (81.4%)	34 (18.1%)	1 (0.5%)	188 (100.0%)
DOSE	240 (77.9%)	60 (19.5%)	8 (2.6%)	308 (100.0%)
ESCAPE	149 (34.4%)	284 (65.6%)	0 (0.0%)	433 (100.0%)
EXACT	228 (90.1%)	24 (9.5%)	1 (0.4%)	253 (100.0%)
FIGHT	256 (85.3%)	37 (12.3%)	7 (2.3%)	300 (100.0%)
GUIDE-IT	787 (88.0%)	81 (9.1%)	26 (2.9%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	108 (98.2%)	1 (0.9%)	1 (0.9%)	110 (100.0%)
RELAX	207 (95.8%)	9 (4.2%)	0 (0.0%)	216 (100.0%)
ROSE	263 (73.1%)	87 (24.2%)	10 (2.8%)	360 (100.0%)
SCD-HeFT	2,056 (81.6%)	460 (18.2%)	5 (0.2%)	2,521 (100.0%)
SOLVD Prevent	3,994 (94.5%)	213 (5.0%)	21 (0.5%)	4,228 (100.0%)
SOLVD Registry	4,993 (79.6%)	1,067 (17.0%)	213 (3.4%)	6,273 (100.0%)
SOLVD Treat	1,954 (76.1%)	606 (23.6%)	9 (0.4%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	15,388 (56.3%)	2,963 (10.8%)	8,962 (32.8%)	27,313 (100.0%)

Systolic blood pressure

Variable used: sbp

Additional label: NA

Study	Hypertension	Hypotension	Normal	Unknown	Total
ATHENA	84 (23.3%)	0 (0.0%)	274 (76.1%)	2 (0.6%)	360 (100.0%)
CARRESS	16 (8.5%)	0 (0.0%)	171 (91.0%)	1 (0.5%)	188 (100.0%)
DOSE	51 (16.6%)	2 (0.6%)	254 (82.5%)	1 (0.3%)	308 (100.0%)
ESCAPE	14 (3.2%)	54 (12.5%)	362 (83.6%)	3 (0.7%)	433 (100.0%)
EXACT	13 (5.1%)	12 (4.7%)	228 (90.1%)	0 (0.0%)	253 (100.0%)
FIGHT	15 (5.0%)	14 (4.7%)	269 (89.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	119 (13.3%)	47 (5.3%)	723 (80.9%)	5 (0.6%)	894 (100.0%)
HF-ACTION	208 (9.8%)	126 (5.9%)	1,792 (84.1%)	4 (0.2%)	2,130 (100.0%)
INDIE-HFpEF	27 (25.7%)	0 (0.0%)	78 (74.3%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	32 (29.1%)	0 (0.0%)	78 (70.9%)	0 (0.0%)	110 (100.0%)
RELAX	50 (23.1%)	0 (0.0%)	166 (76.9%)	0 (0.0%)	216 (100.0%)
ROSE	49 (13.6%)	0 (0.0%)	311 (86.4%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	451 (17.9%)	61 (2.4%)	2,000 (79.3%)	9 (0.4%)	2,521 (100.0%)
SOLVD Prevent	922 (21.8%)	12 (0.3%)	3,287 (77.7%)	7 (0.2%)	4,228 (100.0%)
SOLVD Registry	1,777 (28.3%)	57 (0.9%)	4,229 (67.4%)	210 (3.3%)	6,273 (100.0%)
SOLVD Treat	586 (22.8%)	20 (0.8%)	1,958 (76.2%)	5 (0.2%)	2,569 (100.0%)
STICH	458 (17.5%)	40 (1.5%)	2,106 (80.4%)	16 (0.6%)	2,620 (100.0%)
TOPCAT	872 (25.3%)	10 (0.3%)	2,559 (74.3%)	4 (0.1%)	3,445 (100.0%)
Total	5,744 (21.0%)	455 (1.7%)	20,845 (76.3%)	269 (1.0%)	27,313 (100.0%)

Systolic blood pressure value

Variable used: sbp_val

Additional label: SBP, mm Hg

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	2	90	107.00	122.0	138.00	200	124.14	21.10
CARRESS	188	1	90	104.00	114.0	125.00	187	116.32	16.77
DOSE	308	1	84	104.00	115.0	132.00	185	119.20	20.14
ESCAPE	433	3	60	93.25	104.0	116.75	170	105.64	16.29
EXACT	253	0	75	100.00	108.0	120.00	176	110.34	15.86
FIGHT	300	2	75	99.00	108.0	119.00	185	109.98	15.72
GUIDE-IT	894	5	70	101.00	114.0	128.00	190	115.97	19.74
HF-ACTION	2130	4	66	100.00	110.0	126.00	182	113.78	18.27
INDIE-HFpEF	105	0	96	120.00	128.0	140.00	186	130.48	16.77
NEAT-HFpEF	110	0	100	118.00	127.5	141.00	176	130.34	16.09
RELAX	216	0	98	113.00	126.0	138.00	177	127.89	17.33
ROSE	360	0	90	103.00	114.0	127.00	188	117.64	18.58
SCD-HeFT	2521	9	72	106.00	118.0	130.00	200	119.70	19.46
SOLVD Prevent	4228	7	85	112.00	124.0	136.00	180	125.41	16.43
SOLVD Registry	6273	210	50	110.00	125.0	140.00	280	127.56	21.58
SOLVD Treat	2569	5	85	112.00	124.0	136.00	180	124.90	17.53
STICH	2620	16	72	110.00	120.0	130.00	200	120.88	18.13
TOPCAT	3445	4	80	120.00	130.0	140.00	240	129.22	13.97
Overall	27313	269	50	110.00	120.0	135.00	280	123.32	19.16

Sex

Variable used: sex

Additional label: Sex

Study	Female	Male	Unknown	Total
ATHENA	129 (35.8%)	231 (64.2%)	0 (0.0%)	360 (100.0%)
CARRESS	47 (25.0%)	141 (75.0%)	0 (0.0%)	188 (100.0%)
DOSE	82 (26.6%)	226 (73.4%)	0 (0.0%)	308 (100.0%)
ESCAPE	112 (25.9%)	321 (74.1%)	0 (0.0%)	433 (100.0%)
EXACT	45 (17.8%)	208 (82.2%)	0 (0.0%)	253 (100.0%)
FIGHT	64 (21.3%)	236 (78.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	286 (32.0%)	608 (68.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	599 (28.1%)	1,531 (71.9%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	59 (56.2%)	46 (43.8%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	63 (57.3%)	47 (42.7%)	0 (0.0%)	110 (100.0%)
RELAX	104 (48.1%)	112 (51.9%)	0 (0.0%)	216 (100.0%)
ROSE	96 (26.7%)	264 (73.3%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	588 (23.3%)	1,933 (76.7%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	476 (11.3%)	3,752 (88.7%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	1,640 (26.1%)	4,630 (73.8%)	3 (0.0%)	6,273 (100.0%)
SOLVD Treat	504 (19.6%)	2,065 (80.4%)	0 (0.0%)	2,569 (100.0%)
STICH	381 (14.5%)	2,235 (85.3%)	4 (0.2%)	2,620 (100.0%)
TOPCAT	1,775 (51.5%)	1,670 (48.5%)	0 (0.0%)	3,445 (100.0%)
Total	7,050 (25.8%)	20,256 (74.2%)	7 (0.0%)	27,313 (100.0%)

Six minute walk distance, m

Variable used: sixmw_dist_m

Additional label: 6MW, m

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	161	0.91	91.44	167.64	276.99	505.36	182.71	114.34
EXACT	253	4	3.00	190.00	290.00	373.00	599.00	278.08	121.73
FIGHT	300	33	3.60	143.71	222.60	311.45	675.00	228.76	116.69
GUIDE-IT	894	148	1.22	183.25	289.75	370.83	950.00	285.55	140.76
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	0	23.00	229.00	307.50	382.25	547.00	300.50	110.83
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	124	12.20	256.10	344.50	414.60	914.60	336.15	123.67
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	941	9.14	270.00	348.00	415.00	795.00	338.71	118.82
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	21487	0.91	228.00	322.00	400.00	950.00	314.52	129.95

Sodium

Variable used: sodium

Additional label: Sodium

Study	< 130	130-140	140+	Unknown	Total
ATHENA	7 (1.9%)	161 (44.7%)	192 (53.3%)	0 (0.0%)	360 (100.0%)
CARRESS	7 (3.7%)	118 (62.8%)	62 (33.0%)	1 (0.5%)	188 (100.0%)
DOSE	5 (1.6%)	190 (61.7%)	113 (36.7%)	0 (0.0%)	308 (100.0%)
ESCAPE	31 (7.2%)	287 (66.3%)	112 (25.9%)	3 (0.7%)	433 (100.0%)
EXACT	5 (2.0%)	154 (60.9%)	94 (37.2%)	0 (0.0%)	253 (100.0%)
FIGHT	10 (3.3%)	220 (73.3%)	68 (22.7%)	2 (0.7%)	300 (100.0%)
GUIDE-IT	14 (1.6%)	515 (57.6%)	332 (37.1%)	33 (3.7%)	894 (100.0%)
HF-ACTION	12 (0.6%)	1,023 (48.0%)	860 (40.4%)	235 (11.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	36 (34.3%)	68 (64.8%)	1 (1.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	47 (42.7%)	62 (56.4%)	1 (0.9%)	110 (100.0%)
RELAX	1 (0.5%)	81 (37.5%)	111 (51.4%)	23 (10.6%)	216 (100.0%)
ROSE	8 (2.2%)	207 (57.5%)	145 (40.3%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	17 (0.7%)	1,339 (53.1%)	1,145 (45.4%)	20 (0.8%)	2,521 (100.0%)
SOLVD Prevent	11 (0.3%)	1,561 (36.9%)	2,591 (61.3%)	65 (1.5%)	4,228 (100.0%)
SOLVD Registry	156 (2.5%)	3,158 (50.3%)	2,385 (38.0%)	574 (9.2%)	6,273 (100.0%)
SOLVD Treat	8 (0.3%)	1,135 (44.2%)	1,384 (53.9%)	42 (1.6%)	2,569 (100.0%)
STICH	39 (1.5%)	1,274 (48.6%)	1,256 (47.9%)	51 (1.9%)	2,620 (100.0%)
TOPCAT	24 (0.7%)	1,128 (32.7%)	2,287 (66.4%)	6 (0.2%)	3,445 (100.0%)
Total	355 (1.3%)	12,634 (46.3%)	13,267 (48.6%)	1,057 (3.9%)	27,313 (100.0%)

Sodium value

Variable used: sodium_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	0	122.0	138	140.0	142	148	139.59	3.69
CARRESS	188	1	125.0	135	137.0	140	148	137.20	4.13
DOSE	308	0	123.0	136	138.5	141	148	138.21	3.69
ESCAPE	433	3	121.0	135	137.0	140	147	136.66	4.44
EXACT	253	0	125.0	137	139.0	140	146	138.30	3.43
FIGHT	300	2	126.0	134	137.0	139	146	136.74	3.60
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	235	3.7	137	139.0	141	190	139.04	4.71
INDIE-HFpEF	105	1	133.0	139	140.0	142	146	140.28	2.33
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	23	128.0	138	140.0	141	147	139.66	3.23
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	20	118.0	137	139.0	141	151	139.12	3.30
SOLVD Prevent	4228	65	129.0	139	140.0	142	149	140.21	2.88
SOLVD Registry	6273	574	101.0	136	139.0	141	165	138.34	4.10
SOLVD Treat	2569	42	129.0	138	140.0	142	149	139.68	3.18
STICH	2620	51	3.6	137	139.0	142	152	139.13	5.69
TOPCAT	3445	6	119.0	139	141.0	144	162	141.21	4.21
Overall	27313	2387	3.6	137	140.0	142	190	139.37	4.14

On statin

Variable used: statin

Additional label: Statin

Study	No	Yes	Unknown	Total
ATHENA	147 (40.8%)	213 (59.2%)	0 (0.0%)	360 (100.0%)
CARRESS	48 (25.5%)	140 (74.5%)	0 (0.0%)	188 (100.0%)
DOSE	109 (35.4%)	199 (64.6%)	0 (0.0%)	308 (100.0%)
ESCAPE	290 (67.0%)	143 (33.0%)	0 (0.0%)	433 (100.0%)
EXACT	74 (29.2%)	179 (70.8%)	0 (0.0%)	253 (100.0%)
FIGHT	82 (27.3%)	218 (72.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	364 (40.7%)	530 (59.3%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	50 (45.5%)	60 (54.5%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	113 (31.4%)	247 (68.6%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,556 (61.7%)	965 (38.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	581 (22.2%)	2,039 (77.8%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	1,640 (47.6%)	1,805 (52.4%)	0 (0.0%)	3,445 (100.0%)
Total	7,400 (27.1%)	6,738 (24.7%)	13,175 (48.2%)	27,313 (100.0%)

STICH hypothesis 1

Variable used: stich_h1

Additional label: NA

Study	Yes	Unknown	Total
ATHENA	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	1,212 (46.3%)	1,408 (53.7%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,212 (4.4%)	26,101 (95.6%)	27,313 (100.0%)

STICH hypothesis 2

Variable used: stich_h2

Additional label: NA

Study	Yes	Unknown	Total
ATHENA	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	1,000 (38.2%)	1,620 (61.8%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,000 (3.7%)	26,313 (96.3%)	27,313 (100.0%)

Stroke

Variable used: stroke

Additional label: Stroke

Study	No	Yes	Unknown	Total
ATHENA	305 (84.7%)	55 (15.3%)	0 (0.0%)	360 (100.0%)
CARRESS	163 (86.7%)	25 (13.3%)	0 (0.0%)	188 (100.0%)
DOSE	271 (88.0%)	37 (12.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	393 (90.8%)	40 (9.2%)	0 (0.0%)	433 (100.0%)
EXACT	228 (90.1%)	25 (9.9%)	0 (0.0%)	253 (100.0%)
FIGHT	270 (90.0%)	30 (10.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	799 (89.4%)	95 (10.6%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,912 (89.8%)	218 (10.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	100 (95.2%)	5 (4.8%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	104 (94.5%)	6 (5.5%)	0 (0.0%)	110 (100.0%)
RELAX	201 (93.1%)	15 (6.9%)	0 (0.0%)	216 (100.0%)
ROSE	329 (91.4%)	31 (8.6%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,355 (93.4%)	166 (6.6%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	3,979 (94.1%)	249 (5.9%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	2,371 (92.3%)	198 (7.7%)	0 (0.0%)	2,569 (100.0%)
STICH	2,433 (92.9%)	187 (7.1%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	3,180 (92.3%)	265 (7.7%)	0 (0.0%)	3,445 (100.0%)
Total	19,393 (71.0%)	1,647 (6.0%)	6,273 (23.0%)	27,313 (100.0%)

Systemic vascular resistance

Variable used: svr

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	218	405.05	1189.16	1629.61	2280.21	42665.60	2178.31	3224.31
EXACT	253	61	744.51	1277.90	1603.82	2144.90	5098.10	1761.43	683.47
FIGHT	300	138	416.79	906.27	1141.02	1469.05	4610.68	1222.58	532.00
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	14	787.92	1250.67	1516.19	1812.51	3760.52	1623.17	580.15
RELAX	216	103	423.49	1208.73	1421.28	1833.06	3518.47	1550.64	532.33
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	5541	538.71	1188.43	1515.13	1927.06	7486.03	1619.76	624.54
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	1314	585.06	1305.59	1668.63	2092.03	6505.62	1767.02	663.86
TOPCAT	3445	2811	708.59	1602.33	1955.74	2350.69	6688.85	2061.68	708.74
Overall	27313	23863	405.05	1274.22	1648.60	2095.35	42665.60	1778.59	1044.62

Triglyceride value

Variable used: tg_val

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	15	35	73	97	142	960	120.19	84.94
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	27028	35	73	97	142	960	120.19	84.94

On thiazide diuretic

Variable used: thiazide

Additional label: Thiazide

Study	No	Yes	Unknown	Total
ATHENA	324 (90.0%)	36 (10.0%)	0 (0.0%)	360 (100.0%)
CARRESS	135 (71.8%)	53 (28.2%)	0 (0.0%)	188 (100.0%)
DOSE	255 (82.8%)	53 (17.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	371 (85.7%)	62 (14.3%)	0 (0.0%)	433 (100.0%)
EXACT	204 (80.6%)	49 (19.4%)	0 (0.0%)	253 (100.0%)
FIGHT	261 (87.0%)	39 (13.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	836 (93.5%)	58 (6.5%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,935 (90.8%)	195 (9.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	92 (87.6%)	13 (12.4%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	91 (82.7%)	19 (17.3%)	0 (0.0%)	110 (100.0%)
RELAX	177 (81.9%)	39 (18.1%)	0 (0.0%)	216 (100.0%)
ROSE	294 (81.7%)	66 (18.3%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,346 (93.1%)	175 (6.9%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	3,847 (91.0%)	381 (9.0%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	2,256 (87.8%)	313 (12.2%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,150 (62.4%)	1,295 (37.6%)	0 (0.0%)	3,445 (100.0%)
Total	15,574 (57.0%)	2,846 (10.4%)	8,893 (32.6%)	27,313 (100.0%)

Troponin I

Variable used: tni

Additional label: Troponin I

Study	Abnormal	Normal	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	68 (36.2%)	114 (60.6%)	6 (3.2%)	188 (100.0%)
DOSE	80 (26.0%)	210 (68.2%)	18 (5.8%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	212 (98.1%)	0 (0.0%)	4 (1.9%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	360 (1.3%)	324 (1.2%)	26,629 (97.5%)	27,313 (100.0%)

Troponin I value

Variable used: tni_val

Additional label: Troponin I, ng/ml

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	6	0.00	0.02	0.03	0.06	10.36	0.17	0.86
DOSE	308	18	0.00	0.01	0.02	0.04	0.71	0.05	0.07
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	4	1.76	5.36	9.53	19.67	549.89	22.80	46.29
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26629	0.00	0.02	0.04	4.46	549.89	7.13	27.80

Tobacco use

Variable used: tob

Additional label: Ever smoking

Study	No	Yes	Unknown	Total
ATHENA	131 (36.4%)	229 (63.6%)	0 (0.0%)	360 (100.0%)
CARRESS	64 (34.0%)	124 (66.0%)	0 (0.0%)	188 (100.0%)
DOSE	102 (33.1%)	206 (66.9%)	0 (0.0%)	308 (100.0%)
ESCAPE	124 (28.6%)	309 (71.4%)	0 (0.0%)	433 (100.0%)
EXACT	85 (33.6%)	168 (66.4%)	0 (0.0%)	253 (100.0%)
FIGHT	105 (35.0%)	195 (65.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	590 (66.0%)	304 (34.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	985 (46.2%)	1,145 (53.8%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	57 (54.3%)	48 (45.7%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	50 (45.5%)	60 (54.5%)	0 (0.0%)	110 (100.0%)
RELAX	80 (37.0%)	136 (63.0%)	0 (0.0%)	216 (100.0%)
ROSE	127 (35.3%)	233 (64.7%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	647 (25.7%)	1,874 (74.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	887 (21.0%)	3,341 (79.0%)	0 (0.0%)	4,228 (100.0%)
SOLVD Registry	2,197 (35.0%)	4,076 (65.0%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	597 (23.2%)	1,972 (76.8%)	0 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	2,177 (63.2%)	1,268 (36.8%)	0 (0.0%)	3,445 (100.0%)
Total	9,005 (33.0%)	15,688 (57.4%)	2,620 (9.6%)	27,313 (100.0%)

Total bilirubin value

Variable used: tot_bili

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	67	0.10	0.5	0.8	1.2	4.5	0.95	0.65
DOSE	308	118	0.20	0.6	1.0	1.5	3.8	1.20	0.75
ESCAPE	433	87	0.04	0.6	1.1	1.7	9.5	1.36	1.18
EXACT	253	13	0.18	0.5	0.7	1.1	3.1	0.85	0.51
FIGHT	300	28	0.10	0.6	0.9	1.2	3.9	1.01	0.61
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	2	0.20	0.3	0.5	0.7	2.9	0.63	0.44
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	10	0.20	0.4	0.6	0.8	2.9	0.64	0.34
ROSE	360	93	0.10	0.6	0.9	1.4	3.7	1.11	0.69
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25568	0.04	0.5	0.8	1.3	9.5	1.02	0.78

Total cholesterol value

Variable used: tot_chol

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	128	59.00	94.00	116.00	138.25	195	117.27	30.57
DOSE	308	207	58.00	100.54	116.01	146.00	434	129.69	50.04
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	150	50.27	117.20	150.04	178.50	299	150.93	45.27
FIGHT	300	15	47.00	109.00	131.00	163.00	378	137.59	44.55
GUIDE-IT	894	808	70.77	118.25	148.00	173.75	309	148.49	42.60
HF-ACTION	2130	746	1.47	122.75	155.00	186.00	1460	147.40	77.56
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	125	85.00	137.00	158.00	188.50	319	164.58	42.31
ROSE	360	220	50.00	99.00	123.00	152.00	293	130.40	42.49
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25063	1.47	115.00	147.00	179.00	1460	144.40	67.10

Tricuspid velocity value

Variable used: tr_val

Additional label: TR velocity

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	213	0.05	2.67	2.94	3.30	4.4	2.97	0.58
EXACT	253	83	1.20	2.50	2.80	3.10	4.7	2.84	0.52
FIGHT	300	63	1.20	2.50	2.90	3.20	4.1	2.85	0.53
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	37	1.80	2.20	2.50	2.77	3.9	2.52	0.38
RELAX	216	78	1.90	2.60	2.80	3.20	4.0	2.88	0.43
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2024	1.00	2.50	2.80	3.20	4.5	2.86	0.54
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25879	0.05	2.50	2.80	3.20	4.7	2.86	0.53

Treatment group

Variable used: txgroup

Additional label: Treatment group

Study	Aerobic exercise training	Allopurinol	Amiodarone	Biomarker-guided	Bolus dosing	CABG	CABG+SVR	Continuous infusion	Diuretics	Dopamine	Enalapril	Group 1	Group 2	High dose spironolactone	ICD therapy	Liraglutide	Low dose spironolactone	Medical therapy	Nesiritide	Nitrite first	Placebo	Placebo first	Pulm Artery Catheter	Sildenafil	Spironolactone	Standard care	Ultrafiltration	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	182 (50.6%)	0 (0.0%)	0 (0.0%)	43 (11.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	135 (37.5%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	94 (50.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	94 (50.0%)	0 (0.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	156 (50.6%)	0 (0.0%)	0 (0.0%)	152 (49.4%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	215 (49.7%)	0 (0.0%)	0 (0.0%)	218 (50.3%)	0 (0.0%)	0 (0.0%)	433 (100.0%)
EXACT	0 (0.0%)	128 (50.6%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	125 (49.4%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	154 (51.3%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	146 (48.7%)	0 (0.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	446 (49.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	448 (50.1%)	0 (0.0%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,060 (49.8%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1,070 (50.2%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	53 (50.5%)	0 (0.0%)	52 (49.5%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	51 (46.4%)	59 (53.6%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	113 (52.3%)	0 (0.0%)	103 (47.7%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	122 (33.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	119 (33.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	119 (33.1%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	845 (33.5%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	829 (32.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	847 (33.6%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,110 (49.9%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,117 (50.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (0.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,270 (100.0%)	0 (0.0%)	3 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1,285 (50.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1,283 (49.9%)	0 (0.0%)	1 (0.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1,033 (39.4%)	501 (19.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	602 (23.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	484 (18.5%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1,722 (50.0%)	1,723 (50.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)
Total	1,060 (3.9%)	128 (0.5%)	845 (3.1%)	446 (1.6%)	156 (0.6%)	1,033 (3.8%)	501 (1.8%)	152 (0.6%)	94 (0.3%)	122 (0.4%)	3,395 (12.4%)	51 (0.2%)	59 (0.2%)	182 (0.7%)	829 (3.0%)	154 (0.6%)	43 (0.2%)	602 (2.2%)	119 (0.4%)	53 (0.2%)	2,242 (8.2%)	52 (0.2%)	215 (0.8%)	113 (0.4%)	1,722 (6.3%)	12,362 (45.3%)	94 (0.3%)	489 (1.8%)	27,313 (100.0%)

Treatment group 2

Variable used: txgroup2

Additional label: NA

Study	ICD therapy	Medical therapy	No ICD	Spironolactone	Standard care	Surgical therapy	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	225 (62.5%)	135 (37.5%)	0 (0.0%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	829 (32.9%)	0 (0.0%)	1,692 (67.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	602 (23.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1,534 (58.5%)	484 (18.5%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	829 (3.0%)	602 (2.2%)	1,692 (6.2%)	225 (0.8%)	135 (0.5%)	1,534 (5.6%)	22,296 (81.6%)	27,313 (100.0%)

Uric acid value

Variable used: uric_val

Additional label: Uric acid, mg/dL

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	7	4.10	8.80	10.70	12.40	17.50	10.64	2.58
DOSE	308	15	2.40	8.00	9.70	11.40	18.70	9.81	2.58
ESCAPE	433	433	NA	NA	NA	NA	NA	NA	NA
EXACT	253	8	6.00	10.10	11.10	12.10	18.60	11.28	1.81
FIGHT	300	280	4.50	7.00	9.55	11.57	12.30	8.91	2.69
GUIDE-IT	894	792	0.16	0.38	0.52	0.62	0.88	0.50	0.16
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	4	0.50	5.80	7.40	8.50	12.60	7.33	2.18
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	26260	0.16	7.10	9.60	11.40	18.70	8.88	3.77

Valvular disease

Variable used: valvdz

Additional label: Valvular disease

Study	No	Yes	Unknown	Total
ATHENA	228 (63.3%)	132 (36.7%)	0 (0.0%)	360 (100.0%)
CARRESS	41 (21.8%)	147 (78.2%)	0 (0.0%)	188 (100.0%)
DOSE	52 (16.9%)	256 (83.1%)	0 (0.0%)	308 (100.0%)
ESCAPE	358 (82.7%)	75 (17.3%)	0 (0.0%)	433 (100.0%)
EXACT	40 (15.8%)	213 (84.2%)	0 (0.0%)	253 (100.0%)
FIGHT	190 (63.3%)	110 (36.7%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	100 (95.2%)	5 (4.8%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	104 (94.5%)	6 (5.5%)	0 (0.0%)	110 (100.0%)
RELAX	61 (28.2%)	155 (71.8%)	0 (0.0%)	216 (100.0%)
ROSE	43 (11.9%)	317 (88.1%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,109 (83.7%)	412 (16.3%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	4,669 (74.4%)	1,604 (25.6%)	0 (0.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,150 (82.1%)	470 (17.9%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	10,145 (37.1%)	3,902 (14.3%)	13,266 (48.6%)	27,313 (100.0%)

VAS dyspnea

Variable used: vas_dyspnea

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	3	0	45.00	60	75.00	100	59.23	24.84
CARRESS	188	1	0	30.00	51	75.00	100	51.50	26.83
DOSE	308	2	0	28.25	49	70.75	100	49.25	27.17
ESCAPE	433	228	0	30.00	50	70.00	100	47.34	24.98
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	9	0	39.00	60	80.00	100	57.84	26.41
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	25907	0	35.00	54	75.00	100	53.95	26.44

VAS global

Variable used: vas_global

Additional label: VAS global

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	2	0	29.00	50.0	66.75	100	48.05	25.51
DOSE	308	2	0	25.00	45.5	60.00	98	44.22	23.71
ESCAPE	433	5	0	30.00	40.0	60.00	100	41.82	21.55
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	23	0	50.00	60.0	75.50	703	61.18	29.75
HF-ACTION	2130	53	0	50.00	70.0	80.00	100	65.61	18.92
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	216	NA	NA	NA	NA	NA	NA	NA
ROSE	360	12	0	34.75	52.5	71.00	100	52.59	23.58
SCD-HeFT	2521	2521	NA	NA	NA	NA	NA	NA	NA
SOLVD Prevent	4228	1767	10	50.00	70.0	80.00	100	67.85	21.54
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	226	10	50.00	60.0	80.00	100	61.59	23.95
STICH	2620	542	0	40.00	50.0	70.00	100	55.97	19.80
TOPCAT	3445	50	0	50.00	60.0	70.00	100	60.32	17.38
Overall	27313	12820	0	50.00	60.0	80.00	703	60.76	22.03

VO2 value

Variable used: vo2

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	360	NA	NA	NA	NA	NA	NA	NA
CARRESS	188	188	NA	NA	NA	NA	NA	NA	NA
DOSE	308	308	NA	NA	NA	NA	NA	NA	NA
ESCAPE	433	307	4.00	7.90	9.55	11.55	25.3	10.05	3.39
EXACT	253	253	NA	NA	NA	NA	NA	NA	NA
FIGHT	300	300	NA	NA	NA	NA	NA	NA	NA
GUIDE-IT	894	894	NA	NA	NA	NA	NA	NA	NA
HF-ACTION	2130	52	4.50	11.60	14.50	17.78	33.1	14.95	4.63
INDIE-HFpEF	105	105	NA	NA	NA	NA	NA	NA	NA
NEAT-HFpEF	110	110	NA	NA	NA	NA	NA	NA	NA
RELAX	216	1	5.30	10.18	11.70	14.38	20.3	12.29	3.10
ROSE	360	360	NA	NA	NA	NA	NA	NA	NA
SCD-HeFT	2521	2310	1.78	13.35	17.00	20.35	1570.0	24.82	107.13
SOLVD Prevent	4228	4228	NA	NA	NA	NA	NA	NA	NA
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	2569	NA	NA	NA	NA	NA	NA	NA
STICH	2620	2620	NA	NA	NA	NA	NA	NA	NA
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	24683	1.78	11.20	14.20	17.60	1570.0	15.29	30.73

Ventricular tachycardia/fibrillation

Variable used: vtvf

Additional label: VT/VF

Study	No	Yes	Unknown	Total
ATHENA	328 (91.1%)	32 (8.9%)	0 (0.0%)	360 (100.0%)
CARRESS	170 (90.4%)	18 (9.6%)	0 (0.0%)	188 (100.0%)
DOSE	284 (92.2%)	24 (7.8%)	0 (0.0%)	308 (100.0%)
ESCAPE	334 (77.1%)	99 (22.9%)	0 (0.0%)	433 (100.0%)
EXACT	225 (88.9%)	28 (11.1%)	0 (0.0%)	253 (100.0%)
FIGHT	288 (96.0%)	12 (4.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	734 (82.1%)	160 (17.9%)	0 (0.0%)	894 (100.0%)
HF-ACTION	2,130 (100.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	105 (100.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	109 (99.1%)	1 (0.9%)	0 (0.0%)	110 (100.0%)
RELAX	215 (99.5%)	1 (0.5%)	0 (0.0%)	216 (100.0%)
ROSE	322 (89.4%)	38 (10.6%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	2,521 (100.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	7,765 (28.4%)	413 (1.5%)	19,135 (70.1%)	27,313 (100.0%)

On warfarin

Variable used: warfarin

Additional label: Warfarin

Study	No	Yes	Unknown	Total
ATHENA	249 (69.2%)	111 (30.8%)	0 (0.0%)	360 (100.0%)
CARRESS	102 (54.3%)	86 (45.7%)	0 (0.0%)	188 (100.0%)
DOSE	172 (55.8%)	136 (44.2%)	0 (0.0%)	308 (100.0%)
ESCAPE	263 (60.7%)	170 (39.3%)	0 (0.0%)	433 (100.0%)
EXACT	129 (51.0%)	124 (49.0%)	0 (0.0%)	253 (100.0%)
FIGHT	183 (61.0%)	117 (39.0%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	676 (75.6%)	218 (24.4%)	0 (0.0%)	894 (100.0%)
HF-ACTION	1,338 (62.8%)	792 (37.2%)	0 (0.0%)	2,130 (100.0%)
INDIE-HFpEF	83 (79.0%)	22 (21.0%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	91 (82.7%)	19 (17.3%)	0 (0.0%)	110 (100.0%)
RELAX	216 (100.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)
ROSE	195 (54.2%)	165 (45.8%)	0 (0.0%)	360 (100.0%)
SCD-HeFT	1,664 (66.0%)	857 (34.0%)	0 (0.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	2,298 (87.7%)	322 (12.3%)	0 (0.0%)	2,620 (100.0%)
TOPCAT	2,658 (77.2%)	787 (22.8%)	0 (0.0%)	3,445 (100.0%)
Total	10,317 (37.8%)	3,926 (14.4%)	13,070 (47.9%)	27,313 (100.0%)

Weight, kg value

Variable used: weight_kg

Additional label: NA

Study	n	n_missing	min	Q1	median	Q3	max	mean	std
ATHENA	360	2	40.89	75.55	92.59	110.70	216.91	97.28	29.67
CARRESS	188	0	52.21	81.51	99.11	128.84	265.55	106.19	33.23
DOSE	308	5	50.18	80.08	93.39	109.83	221.46	98.20	28.21
ESCAPE	433	4	47.00	69.30	84.70	97.73	134.55	85.52	20.49
EXACT	253	3	48.50	77.82	94.15	112.02	216.60	97.80	25.89
FIGHT	300	1	45.40	78.35	96.10	115.05	127.00	96.14	21.24
GUIDE-IT	894	8	37.86	71.82	85.45	102.19	229.09	90.25	26.62
HF-ACTION	2130	2130	NA	NA	NA	NA	NA	NA	NA
INDIE-HFpEF	105	0	46.00	85.20	100.20	110.70	130.50	98.70	19.80
NEAT-HFpEF	110	0	48.14	81.18	101.82	116.14	211.44	101.83	27.24
RELAX	216	0	50.90	80.90	95.00	111.22	140.90	97.70	21.69
ROSE	360	0	45.45	77.25	90.24	111.56	171.00	95.27	25.39
SCD-HeFT	2521	0	45.50	74.30	86.40	99.50	152.30	88.12	20.04
SOLVD Prevent	4228	67	45.00	71.67	80.29	89.36	136.08	81.23	14.35
SOLVD Registry	6273	6273	NA	NA	NA	NA	NA	NA	NA
SOLVD Treat	2569	51	45.00	68.95	78.00	88.90	136.08	79.72	16.63
STICH	2620	18	44.00	70.00	79.00	90.00	140.00	80.30	16.13
TOPCAT	3445	3445	NA	NA	NA	NA	NA	NA	NA
Overall	27313	12007	37.86	71.67	82.00	95.00	265.55	85.01	20.12

Work status

Variable used: work

Additional label: NA

Study	Disability	Employed	Homemaker	Laid off	Retired	Unemployed	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	213 (23.8%)	250 (28.0%)	18 (2.0%)	7 (0.8%)	341 (38.1%)	38 (4.3%)	27 (3.0%)	894 (100.0%)
HF-ACTION	640 (30.0%)	497 (23.3%)	0 (0.0%)	0 (0.0%)	771 (36.2%)	113 (5.3%)	109 (5.1%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	957 (22.6%)	199 (4.7%)	0 (0.0%)	645 (15.3%)	224 (5.3%)	2,203 (52.1%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	744 (29.0%)	192 (7.5%)	0 (0.0%)	626 (24.4%)	270 (10.5%)	737 (28.7%)	2,569 (100.0%)
STICH	460 (17.6%)	553 (21.1%)	62 (2.4%)	51 (1.9%)	899 (34.3%)	67 (2.6%)	528 (20.2%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,313 (4.8%)	3,001 (11.0%)	471 (1.7%)	58 (0.2%)	3,282 (12.0%)	712 (2.6%)	18,476 (67.6%)	27,313 (100.0%)

Worst symptom

Variable used: worst_sx

Additional label: NA

Study	Abdominal discomfort	Dyspnea	Fatigue	Swelling	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	1 (0.2%)	3 (0.7%)	1 (0.2%)	0 (0.0%)	428 (98.8%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	141 (39.2%)	24 (6.7%)	67 (18.6%)	128 (35.6%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1 (0.0%)	144 (0.5%)	25 (0.1%)	67 (0.2%)	27,076 (99.1%)	27,313 (100.0%)

On direct Xa inhibitor

Variable used: xa_inhibitor

Additional label: NA

Study	No	Yes	Unknown	Total
ATHENA	327 (90.8%)	33 (9.2%)	0 (0.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	0 (0.0%)	0 (0.0%)	253 (100.0%)	253 (100.0%)
FIGHT	293 (97.7%)	7 (2.3%)	0 (0.0%)	300 (100.0%)
GUIDE-IT	793 (88.7%)	101 (11.3%)	0 (0.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	90 (85.7%)	15 (14.3%)	0 (0.0%)	105 (100.0%)
NEAT-HFpEF	102 (92.7%)	8 (7.3%)	0 (0.0%)	110 (100.0%)
RELAX	0 (0.0%)	0 (0.0%)	216 (100.0%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	0 (0.0%)	0 (0.0%)	2,620 (100.0%)	2,620 (100.0%)
TOPCAT	0 (0.0%)	0 (0.0%)	3,445 (100.0%)	3,445 (100.0%)
Total	1,605 (5.9%)	164 (0.6%)	25,544 (93.5%)	27,313 (100.0%)

Y

Variable used: Y

Additional label: NA

Study	Moderate/severe	Normal/Mild	Unknown	Total
ATHENA	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
CARRESS	0 (0.0%)	0 (0.0%)	188 (100.0%)	188 (100.0%)
DOSE	0 (0.0%)	0 (0.0%)	308 (100.0%)	308 (100.0%)
ESCAPE	0 (0.0%)	0 (0.0%)	433 (100.0%)	433 (100.0%)
EXACT	5 (2.0%)	239 (94.5%)	9 (3.6%)	253 (100.0%)
FIGHT	0 (0.0%)	0 (0.0%)	300 (100.0%)	300 (100.0%)
GUIDE-IT	0 (0.0%)	0 (0.0%)	894 (100.0%)	894 (100.0%)
HF-ACTION	0 (0.0%)	0 (0.0%)	2,130 (100.0%)	2,130 (100.0%)
INDIE-HFpEF	0 (0.0%)	0 (0.0%)	105 (100.0%)	105 (100.0%)
NEAT-HFpEF	0 (0.0%)	0 (0.0%)	110 (100.0%)	110 (100.0%)
RELAX	39 (18.1%)	170 (78.7%)	7 (3.2%)	216 (100.0%)
ROSE	0 (0.0%)	0 (0.0%)	360 (100.0%)	360 (100.0%)
SCD-HeFT	0 (0.0%)	0 (0.0%)	2,521 (100.0%)	2,521 (100.0%)
SOLVD Prevent	0 (0.0%)	0 (0.0%)	4,228 (100.0%)	4,228 (100.0%)
SOLVD Registry	0 (0.0%)	0 (0.0%)	6,273 (100.0%)	6,273 (100.0%)
SOLVD Treat	0 (0.0%)	0 (0.0%)	2,569 (100.0%)	2,569 (100.0%)
STICH	12 (0.5%)	1,485 (56.7%)	1,123 (42.9%)	2,620 (100.0%)
TOPCAT	6 (0.2%)	640 (18.6%)	2,799 (81.2%)	3,445 (100.0%)
Total	62 (0.2%)	2,534 (9.3%)	24,717 (90.5%)	27,313 (100.0%)