HeartShare Harmonized Data Release v3 07-08-2025
 
These data were harmonized for use by the HeartShare Consortium using R scripts developed by Dr. David Kao. The HeartShare Data Translation Center performed the harmonization and gratefully acknowledges Dr. Kao for his contributions and the use of his code. 

Minor edits were made for the v3 release according to the Modification Memo below using psHarmonize R software.

These data are intended for use by approved members of the HeartShare Consortium. Importantly, data are released ‘as is’. Any queries or possible inconsistencies noted in the harmonized data should be directed to the HeartShare Data Translation Center.
 
Data from the following studies are included in the harmonized data files:
 
ATHENA
CARRESS
DOSE
ESCAPE
EXACT
FIGHT
GUIDE-IT
HF-ACTION
INDIE-HFpEF
NEAT-HFpEF
RELAX
ROSE
SCD-HeFT
SOLVD Prevent
SOLVD Registry
SOLVD Treat
STICH
TOPCAT

Baseline trial data are provided in both text and numeric format in the following files:

HeartShare trial hdcp phenotype data numeric acad v3 2025-07-08.csv
HeartShare trial hdcp phenotype data text acad v3 2025-07-08.csv

Longitudinal follow up data are in the following file:

HeartShare trial longitudinal phenotype data acad v3 2025-07-08.csv

Clinical outcomes data are in the following file:

HeartShare trial clinical outcomes data acad v3 2025-07-08.csv

Data dictionaries are available in the following files: 

HeartShare harmonized trial dictionary v3 2025-07-08.xlsx
HeartShare outcomes harmonized trial dictionary v3 2025-07-08.xlsx

v3 2025-07-08 UPDATE NOTES

#################################################
##       Harmonization Modification Memo       ##
#################################################

# Academic
# Clinical trials data
# Version 3 changes/updates

################################
## hdcp_phenotype_data_num_v3 ##
################################

- Adding four TOPCAT variables from raw data:
  - QRS duration
  - albumin
  - ast
  - Total bilirubin
  
- Renaming previous "qrs_val" variable for TOPCAT. Renamed to "old_qrs_val"

- Renaming of QRS variables:
  - continuous values to be stored at "qrs_val"
  - categorical to be kept in: "qrs_120" and/or "qrs_cat"
    - "qrs_120" will be binary
    - "qrs_cat" has multiple categorical values

- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"
  
- Glucose values that were less than 25, were multiplied by 18.018. If this new 
  glucose was still less than 25, it was set to NA (missing).
  
  - Glucose values less than 25 are assumed to be in the mmol/l units. We are
    harmonizing glucose values to mg/dL.

- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"

#################################
## hdcp_phenotype_data_text_v3 ##
#################################

- Swapping betablocker coding for TOPCAT
  - Using harmonized version, just swapping Yes/No coding
  
- Adding four TOPCAT variables from raw data:
  - QRS duration
  - albumin
  - ast
  - Total bilirubin
  
- Renaming previous "qrs_val" variable for TOPCAT. Renamed to "old_qrs_val"

- Renaming of QRS variables:
  - continuous values to be stored at "qrs_val"
  - categorical to be kept in: "qrs_120" and/or "qrs_cat"
    - "qrs_120" will be binary
    - "qrs_cat" has multiple categorical values

- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"
  
- Glucose values that were less than 25, were multiplied by 18.018. If this new 
  glucose was still less than 25, it was set to NA (missing).
  
  - Glucose values less than 25 are assumed to be in the mmol/l units. We are
    harmonizing glucose values to mg/dL.

- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"

####################################
## longitudinal_phenotype_data_v3 ##
####################################
    
- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"

#####################################
## hdcp_acute_outcomes_academic_v3 ##
#####################################

- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"

###############################
## hdcp_outcomes_academic_v3 ##
###############################

- Created unique ID across Heartshare participants. Variable
  is called "Heartshare_ID"